&lt;title&gt;The adjuvanticity of gold nanoparticles&lt;/title&gt;

Дыкман, Л. А.; Богатырев, В. А.; Староверов, С. А.; Pristensky, Dmitry V.; Shchyogolev, S. Yu.; Khlebtsov, Nikolai G.

doi:10.1117/12.695006

Cited by 6 publications

(9 citation statements)

References 17 publications

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“…Comparison of our data (Figure 2(b), curve 1) to available numerical data [30][31][32][33][34]36,37], concerning the correlation between position of the maximum of the SPR band and the size of Au-nanoparticles shows that in our case the change in the SPR band reflects the increase in the size of Au-nanoassemblies from 2 to about 50 nm. Of course, this is a very simple estimation, that does not take into account such factors as real shape of Au-assemblies, local dielectric constant or local refractive index [38].…”

Section: Resultsmentioning

confidence: 93%

“…Additional study of visible absorption spectra of Aunanoparticles opens a way to evaluate the size of the assemblies formed by these particles under various conditions [30][31][32][33][34][35][36][37]. Figure 2 shows that the pronounced changes in the visible optical spectrum were observed at the treatment of the ds DNA CLCD with Au-nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

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A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles

Yevdokimov¹,

Skuridin²,

Salyanov³

et al. 2011

JBNB

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Au-nanoparticles (size about 2 nm, but not 5 or 15 nm) are capable of effectively incorporating into quasinematic layers of particles of cholesteric liquid-crystalline dispersion formed by double-stranded nucleic acid molecules of various families (DNA and poly(I)xpoly(C)). This Au-size-dependent process is accompanied by a decrease in amplitudes of abnormal bands in the CD spectra specific to initial cholesteric liquid-crystalline dispersions and simultaneously by an appearance of plasmon resonance band in visible absorption spectrum. The study of properties of particles of cholesteric liquid-crystalline dispersion treated with Au-nanoparticles by means of various physico-chemical methods demonstrates that incorporation of Au-nanoparticles into quasinematic layers of these particles results in two effects: i) it facilitates reorganization of the spatial cholesteric structure of particles, and ii) it induces the formation of Au-clusters in the content of particles. It is not excluded that these effects represent a possible reason for genotoxicity of Au-nanoparticles.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles

Yevdokimov¹,

Skuridin²,

Salyanov³

et al. 2011

JBNB

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“…It is important to note, that SPR (up to the moment of its saturation) is proportional to t 1/2 value. If we accept [34,35] that the displacement of location of SPR band is connected with increase in size of nano-Au linear clusters, the theoretical estimation allows one to speculate about mechanism of these cluster formation inside ds DNA CLCD particles. It is known that the cluster growth is determined by the competition between bulk and surface free energies, which include the internal energy and the entropy of all colloidal particles participating in the cluster formation.…”

Section: Changes In the Absorption Spectrum Caused By The Doping Of Dmentioning

confidence: 99%

“…It is worth noticing that properties typical for small nanoAu [34,35], the fixation of the nanoparticles in quasinematic layers of DNA molecules may cause two optical effects. Firstly, a perturbation of the cholesteric structure of LCD particles followed by a change in their abnormal optical activity may take place.…”

Section: Changes In CD Spectra Caused By the Doping Of Dna Clcd Partimentioning

confidence: 99%

The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

Yevdokimov¹,

Salyanov²,

Штыкова³

et al. 2014

TONANOJ

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Abstract:Two different approaches to the creation of "rigid" (gel-like) DNA particles (or DNA nanoconstructions) are considered. The physicochemical approach is based on the formation of nanobridges between double-stranded DNA molecules ordered in quasinematic layers of cholesteric liquid-crystalline dispersion (CLCD) particles or their salting-out. This approach represents by itself a "chemical gelation" of DNA molecules realized inside the nanometric DNA particles. The formed "rigid" DNA particles have unique physicochemical properties. The nanotechnological approach is based on induction of "physical gelation" as a result of the formation of Au-clusters in the "free" space between double-stranded DNA molecules ordered in CLCD particles. This approach results in the formation of a new "rigid" DNA material. Its distinctive peculiarity, in contrast to the chemically bonded "rigid" DNA particles, consists in a very weak binding affinity to the nuclear membrane filter used for atomic force microscopy. This opens up a possibility for easy manipulations with CLCD particles doped with gold nanoparticles.Keywords: DNA liquid-crystalline dispersions, nanoconstructions of DNA, nanotechnology of nucleic acids, structure of DNA liquid crystals.

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“…Interactions between nanoparticles of different chemical composi tion and structure and biological objects have been studied [7]. Metal oxide nanoparticles are characteri zed by cytotoxic, embryotoxic, and teratogenic effects [6], they accumulate in lymphoid tissue and cause DNA aberrations [1], disorder the blood clotting sys tem work [3]. The toxicity o f nanomaterials depends on their physical nature, method of preparations, size, structure of nanoparticles, and on the biological model on which the trials are carried out.…”

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confidence: 99%

Effects of Nanodispersed Iron on the Morphofunctional Parameters of the Blood System

et al. 2013

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The effects of nanodispersed iron forms on the morphology and function of the blood sys tem were studied. Maghemite and lepidocrocite caused a leukocytic shift towards segmented neutrophil forms, reduction of lymphocyte rigidity, and stimulated their compactization. In addition, the counts of small hyperchromatic erythrocytes with high rigidity increased in the blood flow. The results indicated that a single dose of nanodispersed iron-containing drugs improved the blood respiratory function and its microrheology.

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<title>The adjuvanticity of gold nanoparticles</title>

Cited by 6 publications

References 17 publications

A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles

A Dual Effect of Au-Nanoparticles on Nucleic Acid Cholesteric Liquid-Crystalline Particles

The Physicochemical and Nanotechnological Approaches to Creation of “Rigid” DNA Nanoconstructions

Effects of Nanodispersed Iron on the Morphofunctional Parameters of the Blood System

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