&lt;title&gt;Workstation acquisition node for multicenter imaging studies&lt;/title&gt;

Moore, Stephen; Maffitt, David R.; Blaine, G. James; Bae, Kyongtae T.

doi:10.1117/12.435489

Cited by 7 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MR images are obtained at each PCC using a protocol developed by the HALT PKD Imaging Subcommittee. After acquisition, MR images are reviewed locally and transferred securely, through the World Wide Web, to the Image Analysis Center at the University of Pittsburgh (31).…”

Section: Inclusion Criteriamentioning

confidence: 99%

The HALT Polycystic Kidney Disease Trials

Chapman¹,

Torres²,

Perrone³

et al. 2010

Clinical Journal of the American Society of Nephrology

Self Cite

138

117

View full text Add to dashboard Cite

Background and objectives: Two HALT PKD trials will investigate interventions that potentially slow kidney disease progression in hypertensive autosomal dominant polycystic kidney disease (ADPKD) patients. Studies were designed in early and later stages of ADPKD to assess the impact of intensive blockade of the renin-angiotensin-aldosterone system and level of BP control on progressive renal disease.Design, settings, participants, and measurements: PKD-HALT trials are multicenter, randomized, double-blind, placebocontrolled trials studying 1018 hypertensive ADPKD patients enrolled over 3 yr with 4 to 8 yr of follow-up. In study A, 548 participants, estimated GFR (eGFR) of >60 ml/min per 1. Results: This report describes design issues related to (1) novel endpoints such as kidney volume, (2) home versus office BP measures, and (3) the impact of RAAS inhibition on kidney and patient outcomes, safety, and quality of life.Conclusions: HALT PKD will evaluate potential benefits of rigorous BP control and inhibition of the renin-angiotensinaldosterone system on kidney disease progression in ADPKD.

show abstract

Section: Inclusion Criteriamentioning

confidence: 99%

The HALT Polycystic Kidney Disease Trials

Chapman¹,

Torres²,

Perrone³

et al. 2010

Clinical Journal of the American Society of Nephrology

Self Cite

138

117

View full text Add to dashboard Cite

show abstract

“…WUSTL has a significant history of managing research imaging repositories and creating open-source software to support image transport and de-identification, most notably an acquisition-node software application for clinical trials [15] and regulatory compliance requirements for open-source image-trial management [16]. WUSTL has served as an imaging core in multi-center clinical trials, e.g., the Silent Cerebral Infarct Transfusion Trial (SITT) (∼1,000 patients; 1,552 examinations; 850,000 images) [17] and the CT Image Library for the Lung Screening Study of the National Lung Screening Trial (NLST) (17,309 patients with serial CT screens; 48,723 CT examinations; 12 million images) [18].…”

Section: Introductionmentioning

confidence: 99%

The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository

et al. 2013

View full text Add to dashboard Cite

show abstract

“…To facilitate the collection process, the laptop was pre-loaded with DICOM communications software, virtual private network software, de-identification software, a graphical user interface (GUI) application called the Clinical Studies Workstation (CSW), and a user's guide. The de-identification software and GUI 7 were customized for CTIL collection 5 .…”

Section: Exam Collection Preparationmentioning

confidence: 99%

Collecting 48,000 CT Exams for the Lung Screening Study of the National Lung Screening Trial

et al. 2008

Self Cite

View full text Add to dashboard Cite

From 2002-2004, the Lung Screening Study (LSS) of the National Lung Screening Trial (NLST) enrolled 34,614 participants, aged 55-74 years, at increased risk for lung cancer due to heavy cigarette smoking. Participants, randomized to standard chest X-ray (CXR) or computed tomography (CT) arms at ten screening centers, received up to three imaging screens for lung cancer at annual intervals. Participant medical histories and radiologist-interpreted screening results were transmitted to the LSS coordinating center, while all images were retained at local screening centers. From 2005From -2007, all CT exams were uniformly de-identified and delivered to a central repository, the CT Image Library (CTIL), on external hard drives (94%) or CD/DVD (5.9%), or over a secure Internet connection (0.1%). Of 48,723 CT screens performed, only 176 (0.3%) were unavailable (lost, corrupted, compressed) while 48,547 (99.7%) were delivered to the CTIL. Described here is the experience organizing, implementing, and adapting the clinical-trial workflow surrounding the image retrieval, de-identification, delivery, and archiving of available LSS-NLST CT exams for the CTIL, together with the quality assurance procedures associated with those collection tasks. This collection of CT exams, obtained in a specific, well-defined participant population under a common protocol at evenly spaced intervals, and its attending demographic and clinical information, are now available to lung-disease investigators and developers of computer-aided-diagnosis algorithms. The approach to large scale, multi-center trial CT image collection detailed here may serve as a useful model, while the experience reported should be valuable in the planning and execution of future equivalent endeavors.

show abstract

<title>Workstation acquisition node for multicenter imaging studies</title>

Cited by 7 publications

References 0 publications

The HALT Polycystic Kidney Disease Trials

The HALT Polycystic Kidney Disease Trials

The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository

Collecting 48,000 CT Exams for the Lung Screening Study of the National Lung Screening Trial

Contact Info

Product

Resources

About