LTBI among migrants by Mediterranean Sea: assessing prevalence and its variations according with different thresholds and diagnostic tools. A 10-month on-field experience

Bertoncello, Chiara; Ferro, António; Ferraresso, Anna; Mascarello, Marta; Fonzo, Marco; Minascurta, V; Pistellato, Ilaria; Cabbia, C; Cocchio, Silvia; Baldovin, Tatjana; Baldo, Vincenzo

doi:10.1093/jtm/tay020

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…[ 29 ] Moreover, the diversity of recommendations for different regions and countries demonstrates the limited information available on this topic. [ 30 , 31 ] Knowledge about the effectiveness of LTBI screening or BCG vaccination strategies also remains poor. [ 32 ] The implementation of strategies for the detection and treatment of LTBI cases should be prioritized to prevent new cases of TB in the paediatric and the adult population.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis

Soriano‐Arandes

Caylà²,

Gonçalves

et al. 2020

Medicine

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Introduction: Tuberculosis (TB) is a global infectious disease. In low-incidence countries, paediatric TB affects mostly immigrant children and children of immigrants. We hypothesize that these children are at risk of exposure to Mycobacterium tuberculosis when they travel to the country of origin of their parents to visit friends and relatives (VFR). In this study, we aim to estimate the incidence rate and risk factors associated to latent tuberculosis infection (LTBI) and TB in VFR children. Methods and analysis: A prospective study will be carried out in collaboration with 21 primary health care centres (PCC) and 5 hospitals in Catalonia, Spain. The study participants are children under 15 years of age, either immigrant themselves or born to immigrant parents, who travel to countries with high incidence of TB (≥ 40 cases/100,000 inhabitants). A sample size of 492 children was calculated. Participants will be recruited before traveling, either during a visit to a travel clinic or to their PCC, where a questionnaire including sociodemographic, epidemiological and clinical data will be completed, and a tuberculin skin test (TST) will be performed and read after 48 to 72 hours; patients with a positive TST at baseline will be excluded. A visit will be scheduled eight to twelve-weeks after their return to perform a TST and a QuantiFERON-TB Gold Plus test. The incidence rate of LTBI will be estimated per individual/month and person/year per country visited, and also by age-group. Ethics and dissemination: The study protocol was approved by the Clinical Research Ethics Committee of the Hospital Universitari Mútua Terrassa (code 02/16) and the Clinical Research Ethics Committee of the Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (code P16/094). Articles will be published in indexed scientific journals. Trial registration: Clinical-Trials.gov: NCT04236765

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Section: Discussionmentioning

confidence: 99%

Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis

Soriano‐Arandes

Caylà²,

Gonçalves

et al. 2020

Medicine

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“…Of the 775 patients hospitalised, 167 were for infectious diseases, 21 of whom were TB positive. Another study (Bertoncello et al, 2018) estimated LTBI prevalence in migrant arriving by Mediterranean Sea in 2016. Prevalence rates varied from 25-40% according to tuberculin skin test and interferon-gamma assay values.…”

Section: Screening For Tuberculosis In Europe's Southern Bordermentioning

confidence: 99%

Tackling TB in migrants arriving at Europe’s southern border

Goscé

Girardi

Allel

et al. 2021

International Journal of Infectious Diseases

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Over a quarter of the individuals diagnosed with tuberculosis [TB] in the European Union region are born outside of the area and the proportion has been increasing steadily. Italy is a low TB incidence country with over 50% of TB cases in the foreign-born population primarily due to the high numbers of migrants entering the country via land or sea. As a case study to evaluate the value of screening in newly arrived migrants, the EDETECT-TB project in Italy implemented and evaluated active TB screening in the migrant population at first reception centres to ensure early diagnosis to avoid further spread. Based on a cost-effectiveness analysis from a program provider perspective, a decision tree model allowed the assessment of the value for money of case finding by estimating the cost per case of active TB detected compared with the status quo of no screening. The analysis confirmed that early case detection is a cost-effective intervention in areas with migrants arriving from high TB risk settings. Targeted post-arrival early screening of high TB risk vulnerable new entrants to Italy has a potential role in reducing the spread of TB among migrants.

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Migration Health: Highlights from Inaugural International Society of Travel Medicine (ISTM) Conference on Migration Health

Heywood

Castelli

Greenaway

2019

Curr Infect Dis Rep

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LTBI among migrants by Mediterranean Sea: assessing prevalence and its variations according with different thresholds and diagnostic tools. A 10-month on-field experience

Cited by 7 publications

References 8 publications

Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis

Tuberculosis infection in children visiting friends and relatives in countries with high incidence of tuberculosis

Tackling TB in migrants arriving at Europe’s southern border

Migration Health: Highlights from Inaugural International Society of Travel Medicine (ISTM) Conference on Migration Health

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