2015
DOI: 10.1085/jgp.1454oia11
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LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery

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Cited by 14 publications
(22 citation statements)
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“…Associative learning and memory in the contextual fear conditioning test was also impaired in the NPC1 nmf164 mice compared to wt mice, as evidenced by a 62% reduction in freezing time ( Fig 3H). Mutant NPC1 fails to support cholesterol redistribution and CYP46A1 and AMPA receptor surface delivery during LTP Recent evidence has shown that LTP-triggered cholesterol redistribution and reduction is necessary for the synaptic delivery of AMPA receptors [18], which in turn allows LTP progression. Mutant NPC1 fails to support cholesterol redistribution and CYP46A1 and AMPA receptor surface delivery during LTP Recent evidence has shown that LTP-triggered cholesterol redistribution and reduction is necessary for the synaptic delivery of AMPA receptors [18], which in turn allows LTP progression.…”
Section: Altered Synaptic Function and Behaviour In Npc1 Nmf164 Micementioning
confidence: 99%
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“…Associative learning and memory in the contextual fear conditioning test was also impaired in the NPC1 nmf164 mice compared to wt mice, as evidenced by a 62% reduction in freezing time ( Fig 3H). Mutant NPC1 fails to support cholesterol redistribution and CYP46A1 and AMPA receptor surface delivery during LTP Recent evidence has shown that LTP-triggered cholesterol redistribution and reduction is necessary for the synaptic delivery of AMPA receptors [18], which in turn allows LTP progression. Mutant NPC1 fails to support cholesterol redistribution and CYP46A1 and AMPA receptor surface delivery during LTP Recent evidence has shown that LTP-triggered cholesterol redistribution and reduction is necessary for the synaptic delivery of AMPA receptors [18], which in turn allows LTP progression.…”
Section: Altered Synaptic Function and Behaviour In Npc1 Nmf164 Micementioning
confidence: 99%
“…Mutant NPC1 fails to support cholesterol redistribution and CYP46A1 and AMPA receptor surface delivery during LTP Recent evidence has shown that LTP-triggered cholesterol redistribution and reduction is necessary for the synaptic delivery of AMPA receptors [18], which in turn allows LTP progression. In agreement with the results reported by Brachet et al [18], cLTP induced a 30.4% reduction of cholesterol in the plasma membrane-enriched fraction of wt slices. To maximize the number of synapses undergoing plasticity, cLTP was pharmacologically induced, resulting in synapse activation similar to physiological LTP [29][30][31].…”
Section: Altered Synaptic Function and Behaviour In Npc1 Nmf164 Micementioning
confidence: 99%
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“…45,46 In the case of Rab11, it is widely accepted that its association with recycling endosomes facilitates the delivery of previously endocytosed AMPARs back to the synaptic membrane, 44 interacting with myosin Vb and the endosomal adaptor Rab11-FIP2 upon glycine-induced LTP. 43 Accordingly, dominant-negative Rab11 inhibits the elevation in synaptic AMPARs induced by cholesterol depletion or during chemically induced LTP, 44,56 depletes mobile AMPARs at synapses 57 and blocks LTP formation. 28,44 Interestingly, overexpression of wild-type Rab11 leads to robust glycine-induced AMPAR insertion 44 while short-term removal or addition of Rab11 recycling endosomes from spines does not impair spine expansion during chemically induced LTP in hippocampal neurons.…”
Section: Rab Proteins Regulating Ampar Trafficking Under Ltpmentioning
confidence: 99%