Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co–Cr–Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage

Kyomoto, Masayuki; Moro, Toru; Saiga, Kenichi; Miyaji, Fumiaki; Kawaguchi, Hiroshi; Takatori, Yoshio; Nakamura, Kozo; Ishihara, Kazuhíko

doi:10.1016/j.biomaterials.2009.09.083

Cited by 81 publications

(46 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lack of electrical charges may also reduce interactions with biomolecules . Coating with MPC polymers also dramatically enhances lubricity in aqueous medium that depends on hydrophilicity . The increase in lubricity is due to the low viscosity of the polymer, which, in turn, arises from its structural properties, and from weak interactions with surrounding waters.…”

Section: Surface Properties Of Mpc Polymersmentioning

confidence: 99%

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

Self Cite

186

167

View full text Add to dashboard Cite

In the last 40 years, many strategies to fabricate biocompatible and antithrombogenic polymers have been proposed, especially in Japan. The development of one such polymers composed of 2‐methacryloyloxyethyl phosphorylcholine unit, is described in this review, with specific examples of use in biomedical devices. These polymers are typically incorporated into other materials to effectively prevent unfavorable biological responses and reactions. For example, the polymers suppress protein adsorption and cell adhesion to materials in contact with plasma or whole blood, even in the absence of anticoagulant. These properties are due to the extreme hydrophilicity and electrically neutral nature of the polymers, as well as to the ability of phosphorylcholine to induce bulk‐like behavior in surrounding waters. Accordingly, these polymers have been used worldwide to modify the surfaces and improve the overall biocompatibility of such medical devices as long‐term implantable artificial organs. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 933–943, 2019.

show abstract

Section: Surface Properties Of Mpc Polymersmentioning

confidence: 99%

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Ishihara

2019

J Biomedical Materials Res

Self Cite

186

167

View full text Add to dashboard Cite

show abstract

“…The MPC monomer can copolymerize with various vinyl monomers to form phospholipid polymers having a wide variety of molecular architectures including random, 34,95,104 block, 43,54,89 graft, 20,21,33 charged, 51,[111][112][113] and end functional polymers. 38,44,70,110 They could form cellmembrane-like surfaces by coating the polymer, 36,48,[111][112][113] blending with the polymer, 28,88 and grafting to the polymer chains, 35,47,48 and thereby provided biointerfaces capable of suppressing many biological responses such as nonspecific interactions with proteins, platelets, and cells (Fig. 1).…”

Section: -Methacryloyloxyethyl Phosphorylcholine (Mpc) Polymersmentioning

confidence: 99%

Phospholipid Polymer Biointerfaces for Lab-on-a-Chip Devices

Takai

Ishihara

2010

Ann Biomed Eng

Self Cite

View full text Add to dashboard Cite

This review summarizes recent achievements and progress in the development of various functional 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer biointerfaces for lab-on-a-chip devices and applications. As phospholipid polymers, MPC polymers can form cell-membrane-like surfaces by surface chemistry and physics and thereby provide biointerfaces capable of suppressing protein adsorption and many subsequent biological responses. In order to enable application to microfluidic devices, a number of MPC polymers with diverse functions have been specially designed and synthesized by incorporating functional units such as charge and active ester for generating the microfluidic flow and conjugating biomolecules, respectively. Furthermore, these polymers were incorporated with silane or hydrophobic moiety to construct stable interfaces on various substrate materials such as glass, quartz, poly(methyl methacrylate), and poly(dimethylsiloxane), via a silane-coupling reaction or hydrophobic interactions. The basic interfacial properties of these interfaces have been characterized from multiple aspects of chemistry, physics, and biology, and the suppression of nonspecific bioadsorption and control of microfluidic flow have been successfully achieved using these biointerfaces on a chip. Further, many chip-based biomedical applications such as immunoassays and DNA separation have been accomplished by integrating these biointerfaces on a chip. Therefore, functional phospholipid polymer interfaces are promising and useful for application to lab-on-a-chip devices in biomedicine.

show abstract

“…Migration of the artificial femoral head to the inside of the pelvis caused by the degeneration of the acetabular cartilage has emerged as a serious issue in resurfacing or bipolar hemi-arthroplasty [41]. Surface modification of the cobalt-chromium-molybdenum alloy (Co-Cr-Mo) is one of the promising means of improving lubrication for preventing the migration of the artificial femoral head.…”

Section: Improved Wear Resistant By Surface Grafted Polymer Brushesmentioning

confidence: 99%

Physicochemistry aspects on frictional interfaces

Zhou

Liu

2017

Friction

View full text Add to dashboard Cite

Friction exists wherever relative motion occurs and is the main source of energy consumption. Lubrication plays a significant role in improving fuel efficiency, reducing emissions, and prolonging the service life of machines. Surface interactions between two moving solid surfaces or the flow of a fluid (and/or environment) on a solid surface are the primary causes of friction. Apart from the mechanical design of moving parts, surface physicochemistry is of crucial importance to lubrication. This review deals with the frontier research on controlling friction and lubrication, highlights the importance of physicochemistry aspects, and enumerates the state-of-the-art chemistry solutions to tribological issues. It aims at inspiring talented young scientists from different fields to make significant contributions to the area.

show abstract

Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co–Cr–Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage

Cited by 81 publications

References 34 publications

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Revolutionary advances in 2‐methacryloyloxyethyl phosphorylcholine polymers as biomaterials

Phospholipid Polymer Biointerfaces for Lab-on-a-Chip Devices

Physicochemistry aspects on frictional interfaces

Contact Info

Product

Resources

About