Lugol’s Chromoendoscopy in the Screening of Esophageal Squamous Cell Carcinoma: Time to Take a Closer Look?

Endoscopic detection of esophageallow‐gradesquamous dysplasia: How to predict pathologic upgrades before treatment?

“…This finding is consistent with those conducted by Mori et al 16 who concluded that G‐III stain was associated with mild‐to‐moderate esophageal dysplasia, while G‐IV stain was related to more severe dysplasia. Our data showed a 94.2% sensitivity of Lugol's staining for detecting lesions with a potential risk of HGIN or carcinoma, which is similar to that of the previous studies (91%–100%) 29 . This indicates that Lugol's chromoendoscopy may be used to identify LGIN lesions with a potential risk of histological upgrade.…”

“…Our data showed a 94.2% sensitivity of Lugol's staining for detecting lesions with a potential risk of HGIN or carcinoma, which is similar to that of the previous studies (91%-100%). 29 This indicates that Lugol's chromoendoscopy may be used to identify…”

Narrowed-spectrum Technologies in Endoscopic Imaging of The Upper Gastrointestinal Tract

“…23 The usefulness of Lugol's iodine is due to its reaction with glycogen, which is present in normal squamous epithelium and much less common or absent in dysplastic tissue. 23 LCE staining can be heterogenous and associated with low interobserver agreement, limitations that NSI is capable of overcoming by enhancing specific features associated with ESCC including proliferation of microvessels, intervascular background coloration, and morphological changes of IPCLs (Figure 1 B) (Table 2). [23][24][25][26] Various classification systems exist to characterize ESCC.…”

“…23 LCE staining can be heterogenous and associated with low interobserver agreement, limitations that NSI is capable of overcoming by enhancing specific features associated with ESCC including proliferation of microvessels, intervascular background coloration, and morphological changes of IPCLs (Figure 1 B) (Table 2). [23][24][25][26] Various classification systems exist to characterize ESCC. Inoue's tetrad criteria is based on the four morphological changes of IPCLs mentioned previously; these features can be detected using ME-NBI and have been shown to correlate with the depth of invasion in ESCC.…”

Discordant Pathological and Endoscopic Diagnosis: Consider Floaters

“…Application of Lugol's solution should result in normal mucosa being intensely stained, whereas areas of dysplasia have reduced or absent iodine staining. 3 , 4 There was no obvious region in which the iodine was reduced or absent to suggest dysplasia (Figure 2 ). To confirm the absence of any neoplastic tissue, we opted to perform EMR on the normal-appearing mucosa at the suspected previous biopsy sites.…”