Lumbar discectomy and the diabetic patient: incidence and outcome

Mobbs, Ralph J.; Newcombe, Raymond; Chandran, K. Nadana

doi:10.1054/jocn.2000.0682

Cited by 102 publications

(97 citation statements)

References 15 publications

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“…15 A recurrence rate of 5% to 15% for LDH has been reported. [1][2][3][4][5] Differentiation of recurrent disc herniation from scar formation will allow for improved treatment choices and selection of patients who may benefit from a second surgery. Gadoliniumenhanced MRI is thought to be the best modality to differentiate between these two diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] There have been many studies designed to determine the recurrence of LDH, and various risk factors suggested including disc degeneration, trauma, age, smoking, gender, and obesity. 1,3,6 Radiologically identifiable factors, such as disc degeneration, disc height, and sagittal range of motion have been shown to be related to spinal instability and consequently to rLDH.…”

Section: Introductionmentioning

confidence: 99%

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Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors that influence recurrent lumbar disc herniation

Yaman

Kazanci²,

Yaman

et al. 2017

Hong Kong Med J

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“…The reported incidence varies between 5%-23% [13][14][15][16] . The only risk factors that have consistently shown a strong association are diabetes mellitus [17,18] and the shape and size of the herniation [19] . Symptomatic recurrent herniations are much less common than radiographic ones (10.2% vs 23.1%) [16] .…”

Section: Recurrent Disc Herniationmentioning

confidence: 99%

Common surgical complications in degenerative spinal surgery

Papadakis¹

2013

WJO

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The rapid growth of spine degenerative surgery has led to unrelenting efforts to define and prevent possible complications, the incidence of which is probably higher than that reported and varies according to the region of the spine involved (cervical and thoracolumbar) and the severity of the surgery. Several issues are becoming progressively clearer, such as complication rates in primary versus revision spinal surgery, complications in the elderly, the contribution of minimally invasive surgery to the reduction of complication rate. In this paper the most common surgical complications in degenerative spinal surgery are outlined and discussed.

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“…DM is also considered to be an important aetiological factor in intervertebral disc degeneration [3][4][5]. Previous studies have reported a higher incidence of degenerative disc diseases in patients with DM than in the patients without DM [6]. It is known that DM patients with degenerative disc diseases are relatively younger than non-DM patients.…”

Section: Introductionmentioning

confidence: 99%

Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress

Park

et al. 2014

International Orthopaedics (SICOT)

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Purposes Diabetes mellitus (DM) is thought to be an important aetiological factor in intervertebral disc degeneration. A glucose-mediated increase of oxidative stress is a major causative factor in development of diseases associated with DM. The aim of this study was to investigate the effect of high glucose on mitochondrial damage, oxidative stress and senescence of young annulus fibrosus (AF) cells. Methods AF cells were isolated from four-week-old young rats, cultured, and placed in either 10 % FBS (normal control) or 10 % FBS plus two different high glucose concentrations (0.1 M and 0.2 M) (experimental conditions) for one and three days. We identified and quantified the mitochondrial damage and reactive oxygen species (ROS) (oxidative stress). We also identified and quantified the occurrence of senescence and telomerase activity. Finally, the expressions of proteins were determined related to replicative senescence (p53-p21-pRB) and stress-induced senescence (p16-pRB). Results Two high glucoses enhanced the mitochondrial damage in young rat AF cells, which resulted in an excessive generation of ROS in a dose-and time-dependent manner for one and three days compared to normal control. Two high glucose concentrations increased the occurrence of senescence of young AF cells in a dose-and time-dependent manner. Telomerase activity declined in a dose-and timedependent manner. Both high glucose treatments increased the expressions of p16 and pRB proteins in young rat AF cells for one and three days. However, compared to normal control, the expressions of p53 and p21 proteins were decreased in young rat AF cells treated with both high glucoses for one and three days. Conclusions The present study demonstrated that high glucose-induced oxidative stress accelerates premature stress-induced senescence in young rat AF cells in a doseand time-dependent manner rather than replicative senescence. These results suggest that prevention of excessive generation of oxidative stress by strict blood glucose control could be important to prevent or to delay premature intervertebral disc degeneration in young patients with DM.

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Lumbar discectomy and the diabetic patient: incidence and outcome

Cited by 102 publications

References 15 publications

Factors that influence recurrent lumbar disc herniation

Factors that influence recurrent lumbar disc herniation

Common surgical complications in degenerative spinal surgery

Accelerated premature stress-induced senescence of young annulus fibrosus cells of rats by high glucose-induced oxidative stress

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