Lumbar intradural paragangliomas: report of two cases

Abstract

Paraganglioma (PG) is a rare tumor of the dispersed neuroendocrine system. PG derives from the embryonic sympathetic and parasympathetic nervous system. Paraganglioma is a neoplasm of the dispersed neuroendocrine system that affects a variety of anatomic sites, mainly the head and neck. It occurs commonly in the carotid body, glomus jugulare, mediastinum and retroperitoneum. Primary spinal paragangliomas are quite rare tumors. They are commonly located in the cauda equina region, and manifest their own clinical and radiological features. In this study, two cases of lumbar intradural paragangliomas are presented. Both of the tumors were totally resected with surgery and there was no evidence of recurrence or metastases during follow-up period. It was concluded that paragangliomas should be taken into consideration during the preoperative workup studies of lumbar intradural tumors.

Paraganglioma of the cauda equina: a tertiary centre experience and scoping review of the current literature

“…4 ). We have included 51 case reports [ 1 , 2 , 5 – 14 , 16 – 19 , 22 , 24 , 25 , 27 , 28 , 31 , 34 , 37 – 41 , 44 , 45 , 47 , 48 , 50 , 52 , 53 , 55 – 57 , 59 , 62 , 63 , 69 – 77 ] and 14 case series [ 4 , 15 , 20 , 21 , 30 , 49 , 51 , 58 , 60 , 61 , 67 , 68 , 78 ] (Tables 2 and 3 ). The mean patients’ age was 48.8 ± 1.2 (range 17–75 years).…”

“…4). We have included 51 [4,15,20,21,30,49,51,58,60,61,67,68,78] (Tables 2 and 3). The mean patients' age was 48.8 ± 1.2 (range 17-75 years).…”

Cauda equina neuroendocrine tumors: A single institutional imaging review of cases over two decades

“…1 The primary treatment for CE-NETs is complete surgical removal of the tumor, as it is well-contained. 15,24 This was the case in all of our patients who underwent gross total resection. The prognosis is generally good for CE-NETs after total surgical resection, with a low local recurrence rate.…”

Ga-68 DOTA-NOC PET/CT for the detection of residual/recurrence in a rare case of sacral spinal canal paraganglioma

“…Spinal paraganglioma is a very rare tumor, accounting for around 0.07% of all paragangliomas and 3-4% of all spinal tumors. [ 1 ] The common locations of spinal paraganglioma are the cauda equina and filum terminale regions at the end of spinal column below the 1 st lumbar vertebra (L1 vertebra) level. [ 2 ] The clinical presentation of spinal paragangliomas depends on the level of the affected spinal cord and the degree of compression.…”

“…[ 3 ] Spinal paraganglioma is difficult to distinguish radiologically from other spinal lesions. [ 1 ] Other intradural lesions such as lipoma, schwannoma, meningioma, ependymoma, and dermoid tumor should be included in differential diagnosis, which shows the same MRI imaging feature as paraganglioma. [ 4 5 ] Ga-68 DOTA-NOC PET/CT shows tracer avidity in neural crest tumors, such as paraganglioma, due to the expression of somatostatin receptors.…”