Lumbar paraspinal atypical spindle cell/pleomorphic lipomatous tumor: A report of a rare case

Cheng, Yu‐Wen; Chen, Yangyi; Kuo, Chao‐Hung; Liao, Wei-Chuan; Kwan, Aij‐Lie

doi:10.1002/ccr3.6868

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, there is no risk for dedifferentiation or metastasis. There is only limited description of the imaging appearance of ASCPLT (33)(34)(35). On MRI, the lesion displays variable signal intensity on T1-and T2-weighted images.…”

Section: Differential Diagnosismentioning

confidence: 99%

Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review

OHSHIMA¹,

Nishio²,

Nakayama³

et al. 2023

CDP

View full text Add to dashboard Cite

Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. The lesion typically presents as a relatively small (<5 cm), mobile, slow-growing, painless mass. Magnetic resonance imaging reveals the lesion to be a well-defined subcutaneous mass with a mixture of adipose and non-adipose components. Intense enhancement of the non-adipose component is seen after contrast administration. Histologically, SCL is composed of variable distributions of mature adipocytes, bland spindle cells and ropey collagen bundles and PL also contains pleomorphic and multinucleated floret-like giant cells. By immunohistochemistry, the spindle and pleomorphic/floret-like giant cells of SCL/PL are diffusely positive for CD34 and show loss of nuclear RB transcriptional corepressor 1 (RB1) expression. Recent cytogenetic and molecular genetic studies have shown heterozygous deletions of 13q14, including the RB1 gene. SCL/PL can be successfully treated with simple excision, with a very low recurrence rate. Knowledge of these peculiar tumors is important because it can mimic a variety of benign and malignant soft-tissue tumors. This review provides an updated overview of the clinical, radiological, histopathological, cytogenetic, and molecular genetic features of SCL/PL.

show abstract

Section: Differential Diagnosismentioning

confidence: 99%

Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review

OHSHIMA¹,

Nishio²,

Nakayama³

et al. 2023

CDP

View full text Add to dashboard Cite

show abstract

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update

Nishio,

Nakayama,

Chijiiwa

et al. 2024

Cancers

View full text Add to dashboard Cite

Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks MDM2 gene amplification but can show RB1 gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity.

show abstract

Lumbar paraspinal atypical spindle cell/pleomorphic lipomatous tumor: A report of a rare case

Cited by 2 publications

References 7 publications

Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review

Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update

Contact Info

Product

Resources

About