Lumbar Total Disc Replacement

Franco, Daniel; Largoza, Garrett; Montenegro, Thiago S.; Gonzalez, Glenn A.; Hines, Kevin

doi:10.1016/j.nec.2021.05.010

Cited by 12 publications

(22 citation statements)

References 53 publications

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“…The goal of the device design was to maintain disc space height and preserve motion. Initial results were favorable, but long-term failure due to subsidence into the subchondral bone was observed 2,8,9…”

Section: Historymentioning

confidence: 99%

“…The pathology underlying chronic LBP is multifactorial, with lumbar degeneration disc disease (DDD) being a frequent contributing cause. Nonsurgical treatment options include pain management, anti-inflammatory medications, physical therapy, and lifestyle modifications 1–3. Patients who fail to respond to conservative treatment may benefit from surgical intervention.…”

mentioning

confidence: 99%

“…As an alternative to lumbar fusion, lumbar disc arthroplasty, also known as lumbar total disc replacement (TDR), was introduced. Lumbar disc arthroplasty replaces a degenerated intervertebral disc with a moveable prosthesis, therefore more closely mimicking the functional anatomy and biomechanics of the native intervertebral disc 1,2,4,5…”

mentioning

confidence: 99%

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Lumbar Disc Arthroplasty: Where Are We Now?

Alvarado

O’Toole

2023

Contemporary Spine Surgery

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Lippincott Continuing Medical Education Institute, Inc., is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Lippincott Continuing Medical Education Institute, Inc., designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. To earn CME credit, you must read the CME article and complete the quiz and evaluation assessment survey on the enclosed form, answering at least 70% of the quiz questions correctly. This activity expires on February 28, 2025.LEARNING OBJECTIVES: After participating in this CME activity, the spine surgeon should be better able to: 1. Identify the indications for lumbar disc arthroplasty. 2. Describe the general technique for performing lumbar disc arthroplasty. 3. Assess potential postoperative early and long-term complications after lumbar disc arthroplasty.

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Section: Historymentioning

confidence: 99%

mentioning

confidence: 99%

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Lumbar Disc Arthroplasty: Where Are We Now?

Alvarado

O’Toole

2023

Contemporary Spine Surgery

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“…Cervical total disc arthroplasty is a safe and effective surgical alternative to arthrodesis in properly selected patients with cervical radiculopathy and myelopathy [ 69 ]. In carefully selected patients, lumbar disc replacement surgery has similarly been adopted as an alternative to fusion treatment for degenerative disc disease and may offer similar results to anterior-posterior fusion [ 70 ].…”

Section: Replacementmentioning

confidence: 99%

The Surgical Treatment of Osteoarthritis

Brumat

Kunšič

Novak

et al. 2022

Life

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Osteoarthritis is a degenerative condition affecting the whole joint with the underlying bone, representing a major source of pain, disability, and socioeconomic cost worldwide. Age is considered the strongest risk factor, albeit abnormal biomechanics, morphology, congenital abnormality, deformity, malalignment, limb-length discrepancy, lifestyle, and injury may further increase the risk of the development and progression of osteoarthritis as well. Pain and loss of function are the main clinical features that lead to treatment. Although early manifestations of osteoarthritis are amenable to lifestyle modification, adequate pain management, and physical therapy, disease advancement frequently requires surgical treatment. The symptomatic progression of osteoarthritis with radiographical confirmation can be addressed either with arthroscopic interventions, (joint) preservation techniques, or bone fusion procedures, whereas (joint) replacement is preferentially reserved for severe and end-stage disease. The surgical treatment aims at alleviating pain and disability while restoring native biomechanics. Miscellaneous surgical techniques for addressing osteoarthritis exist. Advanced computer-integrated surgical concepts allow for patient personalization and optimization of surgical treatment. The scope of this article is to present an overview of the fundamentals of conventional surgical treatment options for osteoarthritis of the human skeleton, with emphasis on arthroscopy, preservation, arthrodesis, and replacement. Contemporary computer-assisted orthopaedic surgery concepts are further elucidated.

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“…Intervertebral disc (IVD) disease is a common spinal disorder, which causes neck or back pain in the presence or absence of an underlying neurological disorder. Spinal fusion surgery, artificial disc arthroplasty, and spinal-canal decompression surgery are employed worldwide to treat IVD diseases [ 1 , 2 , 3 , 4 , 5 ]. Spinal fusion is not preferred because it does not preserve intervertebral mobility.…”

Section: Introductionmentioning

confidence: 99%

Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture

Seki

Iwasaki

Makino

et al. 2022

IJMS

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Intervertebral disc (IVD) diseases are common spinal disorders that cause neck or back pain in the presence or absence of an underlying neurological disorder. IVD diseases develop on the basis of degeneration, and there are no established treatments for degeneration. IVD diseases may therefore represent a candidate for the application of regenerative medicine, potentially employing normal human dermal fibroblasts (NHDFs) induced to differentiate into nucleus pulposus (NP) cells. Here, we used a three-dimensional culture system to demonstrate that ectopic expression of MYC, KLF4, NOTO, SOX5, SOX6, and SOX9 in NHDFs generated NP-like cells, detected using Safranin-O staining. Quantitative PCR, microarray analysis, and fluorescence-activated cell sorting revealed that the induced NP cells exhibited a fully differentiated phenotype. These findings may significantly contribute to the development of effective strategies for treating IVD diseases.

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Lumbar Total Disc Replacement

Cited by 12 publications

References 53 publications

Lumbar Disc Arthroplasty: Where Are We Now?

Lumbar Disc Arthroplasty: Where Are We Now?

The Surgical Treatment of Osteoarthritis

Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture

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