Lumican is a potential predictor on the efficacy of concurrent chemoradiotherapy in cervical squamous cell carcinoma

Research progress on the application of organoids in gynecological tumors

“…Therefore, studies have also attempted to improve the treatment of CC tissue with tissue dissociation solution to obtain a sufficient number of cells to the maximum extent ( Hu et al, 2024 ). Moreover, CC organoids can also be used for the detection of different drugs ( Di Fonte et al, 2023 ; Hu et al, 2023 ) and sensitivity testing ( Lin et al, 2023a ). Similar to OC and EC, CC organoids that highly preserve the heterogeneity of the original tissue can be used for personalized and precise treatment, exploring drugs for experimental treatment in patients with different gene mutations ( Lõhmussaar et al, 2021 ; Huang et al, 2023 ).…”

“…To better simulate the treatment response of tumors, organoids were constructed using tissues from different patient sources, and different CC disease models were constructed. The histological and genetic characteristics of the original tumor as well as tumor heterogeneity were preserved, and drug efficacy evaluation or drug sensitivity testing and drug screening experiments were carried out ( Lin et al, 2023a ; Hu et al, 2023 ).…”

“…Hu et al explored the novelty of the therapeutic effect of synchronous radiotherapy and chemotherapy on CESC by constructing organoids for the same ( Hu et al, 2023 ). The research results showed that high expression of Lumican (LUM) affected the immune microenvironment of organoids in patients with CESC treated with synchronous radiotherapy and chemotherapy.…”

“…The research results showed that high expression of Lumican (LUM) affected the immune microenvironment of organoids in patients with CESC treated with synchronous radiotherapy and chemotherapy. High expression of LUM was associated with poor efficacy in CESC patients receiving synchronous radiotherapy and chemotherapy, possibly by affecting the PAR and IL1 signaling pathways of the immune landscape ( Hu et al, 2023 ). Lin et al explored the sensitivity of drug action by constructing CC-derived organoids and found a significant heterogeneity in carcinogenic and tumor microenvironment between CSCC and CAde pathological types.…”