Luminal polyamines upregulate transmural glucose transport in the rat small intestine

Uda, Katsuhiro; Tsujikawa, Tomoyuki; Ihara, Takashi; Fujiyama, Yoshihide; Bamba, Tadao

doi:10.1007/s005350200063

Cited by 14 publications

(5 citation statements)

References 26 publications

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“…Surgery and perfusion were performed as described previously, 12–14 with slight modification. In brief, rats were made to fast for 12 h and then anesthetized with an intraperitoneal injection of sodium pentobarbital (60 mg/kg body weight).…”

Section: Methodsmentioning

confidence: 99%

Rapid absorption of luminal polyamines in a rat small intestine ex vivo model

Uda

Tsujikawa

Fujiyama

et al. 2003

J of Gastro and Hepatol

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Section: Methodsmentioning

confidence: 99%

Rapid absorption of luminal polyamines in a rat small intestine ex vivo model

Uda

Tsujikawa

Fujiyama

et al. 2003

J of Gastro and Hepatol

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“…Notable examples include glucagon-like peptide 2 (1), epidermal growth factor (7), insulin (41), glucagon (10), vasoactive intestinal peptide (32), and prostaglandin E 2 (36). Additional signaling molecules that influence nutrient uptake include epinephrine and adrenergic agonists (21) and polyamines (45). Obviously, the regulation of enterocyte functions is complex and in intact organisms involves the integration of multiple Fig.…”

Section: Discussionmentioning

confidence: 99%

Lumenal adenosine and AMP rapidly increase glucose transport by intact small intestine

Kimura¹,

Turner²,

Braasch³

et al. 2005

American Journal of Physiology-Gastrointestinal and Liver Physi

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Adenosine modulates the intestinal functions of secretion, motility, and immunity, yet little is known about the regulation of nutrient absorption. Therefore, we measured the carrier-mediated uptake of tracer D-[(14)C]glucose (2 microM) by everted sleeves of the mouse intestine after a lumenal exposure to adenosine and a disodium salt of AMP. Rates of glucose uptake by intact tissues increased almost twofold after a 7-min exposure to 5 mM adenosine (a physiological dose). The response was slightly more pronounced for AMP and could be induced by forskolin. The response to adenosine was blocked by theophylline and the A(2) receptor antagonist 3,7-dimethyl-1-proparglyxanthine but not by the A(1) receptor antagonist 8-phenyltheophylline. Glucose uptake by control and AMP-stimulated tissues was inhibited by phloridzin, implying that sodium-dependent glucose transporter 1 (SGLT1) is the responsive transporter, but the involvement of glucose transporter 2 (GLUT2) cannot be excluded. Of clinical relevance, AMP accelerated the systemic availability of 3-O-methylglucose after an oral administration to mice. Our results indicate that adenosine causes a rapid increase in carrier-mediated glucose uptake that is of clinical relevance and acts via receptors linked to a signaling pathway that involves intracellular cAMP production.

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“…Polyamines in chyme are rapidly absorbed by enterocytes, showing the highest polyamine concentrations after feeding, with a significant decrease 2 h later in the lumen [42]. In an isotope marker perfusion test, 61%~79% of radioactive substances can be detected in venous blood 10 min after 14 C-labeled putrescine, spermine and spermidine perfusion [43]. When de novo synthesis of cellular polyamines is impaired or there is an increasing need for polyamines, the utilization of exogenous polyamines is increased [44].…”

Section: Metabolism and Utilization Of Polyamines In The Intestinementioning

confidence: 99%

The Roles of Polyamines in Intestinal Development and Function in Piglets

Tan,

Xiao,

Wang

et al. 2024

Animals

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The gastrointestinal tract plays crucial roles in the digestion and absorption of nutrients, as well as in maintenance of a functional barrier. The development and maturation of the intestine is important for piglets to maintain optimal growth and health. Polyamines are necessary for the proliferation and growth of enterocytes, which play a key role in differentiation, migration, remodeling and integrity of the intestinal mucosa after injury. This review elaborates the development of the structure and function of the intestine of piglets during embryonic, suckling and weaning periods, the utilization and metabolism of polyamines in the intestine, as well as the role of polyamines in intestinal development and mucosal repair. The nutritional intervention to improve intestinal development and functions by modulating polyamine metabolism in piglets is also put forward. These results may help to promote the adaption to weaning in pigs and provide useful information for the development and health of piglets.

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Luminal polyamines upregulate transmural glucose transport in the rat small intestine

Abstract: Luminal polyamines increase glucose absorption in the small intestine via the rapid enhancement of SGLT1 protein in the brush border membrane.

Cited by 14 publications

References 26 publications

Rapid absorption of luminal polyamines in a rat small intestine ex vivo model

Rapid absorption of luminal polyamines in a rat small intestine ex vivo model

Lumenal adenosine and AMP rapidly increase glucose transport by intact small intestine

The Roles of Polyamines in Intestinal Development and Function in Piglets

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