2021
DOI: 10.1111/ajt.16418
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Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine

Abstract: The organ damage incurred during the cold storage (CS) of intestinal grafts has short and long‐term consequences. Animal studies suggest that additional luminal preservation (LP) with polyethylene glycol (PEG) may alleviate this damage. This study aims to validate these findings using human intestines. Ileal segments, perfused intravascularly with IGL‐1 solution, were procured from 32 multiorgan donors and divided into two parts: one containing a PEG 3350‐based solution introduced luminally (LP group) and anot… Show more

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Cited by 9 publications
(10 citation statements)
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“…During severe cold ischemia–reperfusion injury of the intestine, the breakdown of the mucosal barrier function enables bacterial translocation and subsequent septic events. A correlation has previously been established between the rate of this occurrence and the length of the cold ischemic time [ 23 , 37 ]. In view of this, intestinal grafts preserved for extended periods (over 9–10 h) are generally not utilized [ 10 , 23 ].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…During severe cold ischemia–reperfusion injury of the intestine, the breakdown of the mucosal barrier function enables bacterial translocation and subsequent septic events. A correlation has previously been established between the rate of this occurrence and the length of the cold ischemic time [ 23 , 37 ]. In view of this, intestinal grafts preserved for extended periods (over 9–10 h) are generally not utilized [ 10 , 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…A correlation has previously been established between the rate of this occurrence and the length of the cold ischemic time [ 23 , 37 ]. In view of this, intestinal grafts preserved for extended periods (over 9–10 h) are generally not utilized [ 10 , 23 ]. Ways to prolong the preservation time for intestinal grafts are continually being proposed [ 3 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Integrity of the intestinal mucosal barrier is retained by the critical factors of tight junctions and intercellular junctions, including transmembrane proteins such as zonula occludens (ZO), claudins (CLDN) and junctional adhesion molecule. These consist of a complex that forms a selectively permeable seal between adjacent epithelial cells, which is a key element in the paradigm of gut-origin MODS[ 5 , 6 ]. Myosin light chain (MLC) phosphorylation via MLC kinase (MLCK) is critical in pathophysiological modulation of intestinal mucosal barrier breakdown.…”
Section: Introductionmentioning
confidence: 99%
“…Myosin light chain (MLC) phosphorylation via MLC kinase (MLCK) is critical in pathophysiological modulation of intestinal mucosal barrier breakdown. ZO-1 and CLDN-2 behaved specifically as loss and redistribution in intestinal mucosal barrier breakdown and may be regulated via an MLCK-dependent MLC phosphorylation signaling pathway[ 6 - 8 ]. Another critical factor is vascular leakage, which contributes to the intestinal barrier dysfunction after I/R.…”
Section: Introductionmentioning
confidence: 99%