Phone: þ33 472 43 14 53, Fax: þ33 472 43 11 30The behavior of light yield in a wide range of inorganic scintillation crystals formed by isovalent substitution of anions or cations was investigated. The correlation between improvement of light yield in mixed crystals, and the ratios of volumes occupied by the competing atoms (ions) has been analyzed. A phenomenological approach to the prediction of light yield in mixed scintillation crystals allows us to predict the optimal combination of mixing components to reach the best scintillation performance.Relation between the rate of light-yield improvement and ratio of the volumes occupied by the substituted atoms.