Luminescence Resonance Energy Transfer in a Multiple‐Component, Self‐Assembled Supramolecular Hydrogel

Gorai, Tumpa; Maitra, Uday

doi:10.1002/ange.201704738

Cited by 12 publications

(2 citation statements)

References 51 publications

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“…However, the efficient transfer of energy from the donor to acceptor is still challenging, particularly in an aqueous medium. When comparing many other approaches, supramolecular interactions provide a versatile route for organizing donor and acceptor molecules for efficient fluorescence resonance energy transfer (FRET). − Easy control over the FRET efficiency, and hence emission intensity and wavelength (or color) tuning, is easily possible in such systems through simply varying the donor–acceptor ratio and/or modulating their interactions. − However, such approaches rarely work in an aqueous medium because of the competing hydrogen-bonding interactions by water molecules. Rationally designed molecular systems are necessary to address such issues. , …”

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confidence: 99%

Protein-Assisted Supramolecular Control over Fluorescence Resonance Energy Transfer in Aqueous Medium

et al. 2019

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The supramolecular approach has been exploited to modulate the fluorescence resonance energy transfer between an oligofluorene fluorophore and an ionic styryl dye with the assistance of a protein (bovine serum albumin) in aqueous medium. Self-assembled nanoparticles of oligofluorene with a negatively charged surface have functioned as the energy donor, and the positively charged styryl dye acts as the energy acceptor. The hydrophobic pockets in the secondary structure of the added protein enabled complimentary supramolecular interactions in the ternary complex. Moreover, it provided a rigid, nonpolar microenvironment to the dyes, thereby reducing the charge-transfer phenomenon in the dye and favored emission from the locally excited states. As a result, modulation of the energy transfer was observed, yielding significant tuning in emission wavelengths (or color) of the donor–acceptor complex.

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confidence: 99%

Protein-Assisted Supramolecular Control over Fluorescence Resonance Energy Transfer in Aqueous Medium

et al. 2019

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“…The aggregation and network formation of low molecular weight gelators (LMWGs) − has become one of the most expanding areas in current research. Supramolecular hydrogels − are constructed through the self-assembly of individual molecules by using various noncovalent interactions including hydrogen bonding, π–π interactions, van der Waals interactions, hydrophobic interactions, and others to form a micro- and nanonetwork structure with a lot of cavities inside, and under suitable conditions, water molecules are immobilized within the network structure to form hydrogels. Peptide-based hydrogels − attract particular attention not only due to their capacity to form hydrogels via various noncovalent interactions through molecular self-assembly but also owing to their special characteristics including biofunctionality.…”

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confidence: 99%

Amphiphilic Peptide-Based Supramolecular, Noncytotoxic, Stimuli-Responsive Hydrogels with Antibacterial Activity

et al. 2017

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A series of peptides with a long fatty acyl chain covalently attached to the C-terminal part and a free amine (-NH) group at the N-terminus have been designed so that these molecules can be assembled in aqueous medium by using various noncovalent interactions. Five different peptide amphiphiles with a general chemical formula [HN-(CH)CONH-Phe-CONHC (n = 1-5, C = dodecylamine)] have been synthesized, characterized, and examined for self-assembly and hydrogelation. All of these molecules [P1 (n = 1), P2 (n = 2), P3 (n = 3), P4 (n = 4), P5 (n = 5)] form thermoresponsive hydrogels in water (pH 6.6) with a nanofibrillar network structure. Interestingly, the hydrogels obtained from compounds P4 and P5 exhibit potential antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli). Dose-dependent cell-viability studies using MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) by taking human lung carcinoma (A549) cells vividly demonstrates the noncytotoxic nature of these gelator molecules in vitro. Hemolytic studies show nonsignificant or little hemolysis of human erythrocyte cells at the minimum inhibitory concentration (MIC) of these tested bacteria. Interestingly, it has been found that these antibacterial noncytotoxic hydrogels exhibit proteolytic resistance toward the enzymes proteinase K and chymotrypsin. Moreover, the gel strength and gel recovery time have been successfully modulated by varying the alkyl chain length of the N-terminally located amino acid residues. Similarly, the thermal stability of these hydrogels has been nicely tuned by altering the alkyl chain length of the N-terminally located amino acid residues. In the era of antibiotic-resistant strains of bacteria, the discovery of this new class of peptide-based antibacterial, proteolytically stable, injectable, and noncytotoxic soft materials holds future promise for the development of new antibiotics.

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Visualization of Stereoselective Supramolecular Polymers by Chirality‐Controlled Energy Transfer

Sarkar,

Dhiman,

Chalishazar

et al. 2017

Angewandte Chemie

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Chirality-driven self-sorting is envisaged to efficiently control functional properties in supramolecular materials.H owever,t he challenge arises because of al acko f analytical methods to directly monitor the enantioselectivity of the resulting supramolecular assemblies.P resented herein are two fluorescent core-substituted naphthalene-diimidebased donor and acceptor molecules with minimal structural mismatcha nd they comprise strong self-recognizing chiral motifs to determine the self-sorting process.Asaconsequence, stereoselective supramolecular polymerization with an unprecedented chirality control over energy transfer has been achieved. This chirality-controlled energy transfer has been further exploited as an efficient probe to visualize microscopically the chirality driven self-sorting.

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Luminescence Resonance Energy Transfer in a Multiple‐Component, Self‐Assembled Supramolecular Hydrogel

Cited by 12 publications

References 51 publications

Protein-Assisted Supramolecular Control over Fluorescence Resonance Energy Transfer in Aqueous Medium

Protein-Assisted Supramolecular Control over Fluorescence Resonance Energy Transfer in Aqueous Medium

Amphiphilic Peptide-Based Supramolecular, Noncytotoxic, Stimuli-Responsive Hydrogels with Antibacterial Activity

Visualization of Stereoselective Supramolecular Polymers by Chirality‐Controlled Energy Transfer

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