Luminescent CaTiO₃:Yb,Er nanofibers co-conjugated with Rose Bengal and gold nanorods for potential synergistic photodynamic/photothermal therapy

Abstract

CaTiO3:Yb,Er nanofibers, co-conjugated with Rose Bengal and gold nanorods, enable a synergistic photodynamic/photothermal phenomenon for superior cancer cell killing effect.

Multifunctional Electrospun Nanofibers for Enhancing Localized Cancer Treatment

“…However, in the combination of PTT and PDT, it is inconvenient to activate the photothermal agents and photosensitizers using different wavelengths of lights, which also increases the equipment/time cost and undermines their synergistic interactions. [137b] A synergistic anticancer platform based on electrospun CTO:Er,Yb nanofibers, which was co‐conjugated with gold nanorods (AuNRs) and Rose Bengal (RB), was recently investigated for combined photothermal/photodynamic treatment ( Figure ) . The absorption spectra of AuNRs and RB matched well with the red and green emissions of upconversion photoluminescent CTO nanofibers, respectively.…”

“…Step‐by‐step synthesis of CTO–RB–AuNR composite nanofibers. Reproduced with permission . Copyright 2017, Royal Society of Chemistry.…”

Dual targeted and pH-responsive gold nanorods with improved chemotherapy and photothermal ablation for synergistic cancer treatment

“…2,3 Development of highly integrated strategies for precise and efficient therapy of cancer has attracted much attention in the past decades. [4][5][6][7] As a result of cancer heterogeneity, using a synergistic combination of chemotherapy and other therapies would be an optimized design for cancer treatment. [8][9][10] Recently, studies have shown a synergistic antitumor effect when chemotherapy and thermotherapy are combined in nanomedicine.…”

Polymer Dots as Effective Phototheranostic Agents

“…To overcome the limitations of PDT and PTT, construction of phototheranostic nanoplatform integrating PDT and PTT holds great promise (26)(27)(28). As a result, plenty of promising nanomaterials, including inorganic nanoparticle (carbon-based (29,30), transition metal chalcogenide-based (31,32), gold-based (27,33), etc.) and organic nanoparticle (organic small-molecule-based (34,35), polymer-based (36), etc.…”