Luminescent chitosan/carbon dots as an effective nano-drug carrier for neurodegenerative diseases

Mathew, Sheril Ann; Praveena, P.; Dhanavel, S.; Manikandan, R.; Senthilkumar, S.

doi:10.1039/d0ra04599c

Cited by 61 publications

(31 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cytotoxicity on IC-21 and SH-SY5Y cell lines were found to be about 97 % cell viability proving promising against neurodegenerative diseases. The HR-TEM images, Raman spectra (D, G, 2D bands) confirmed the synthesis of CDs, the particle size was confirmed to be 3 nm through DLS study and the PL property denoted excitation at 510 nm with an emission peak at 550 nm that proved efficient for bioimaging for tracing the drug delivery [ 102 ]. Further, there are many CDs and NCDs (with or without surface modifications), which have successfully encapsulated synthetic as well as natural drug for various drug delivery applications, which are tabulated in Table 3 [ [103] , [104] , [105] , [106] , [107] , [108] ].…”

Section: Applications Of Ncds In Drug Deliverymentioning

confidence: 99%

Natural carbon-based quantum dots and their applications in drug delivery: A review

Nair

Haponiuk

Thomas

et al. 2020

Biomedicine & Pharmacotherapy

204

View full text Add to dashboard Cite

Graphical abstract Various NCDs with antimicrobial, anticancer and neurodegenerative drug delivery applications. a) Pleurotus species, b) Hylocereus undatus , c) Curcuma longa L., d) Manilkara zapota (L.) P. Royen , e) Banana leaf, f) Carica papaya , g) Ocimum Sanctum , h) Foeniculum vulgare Mill seeds, i) Azadirachta indica , j) Aloe vera (L.) Burm.f.

show abstract

Section: Applications Of Ncds In Drug Deliverymentioning

confidence: 99%

Natural carbon-based quantum dots and their applications in drug delivery: A review

Nair

Haponiuk

Thomas

et al. 2020

Biomedicine & Pharmacotherapy

204

View full text Add to dashboard Cite

show abstract

“…A variety of luminescent nanoparticles have been developed and engineered for specific applications of drug imaging and delivery systems 42‐44 . Functionalization of nanomaterials increases significantly its targeting properties and leads to considerable progress in the fundamental understanding, diagnosis, and treatment of cancer.…”

Section: Discussionmentioning

confidence: 99%

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

et al. 2021

View full text Add to dashboard Cite

Targeted drug delivery enhances drug efficiency and selectivity without affecting normal cells. Luminescent nanoparticles can be used for tumor imaging as well as selective tumor targeting for drug delivery. In this research, LaVO4:Eu3+ was synthesized, the luminescent nanocrystal was coated by surface polymerization of levodopa in the presence of Paclitaxel (PTX), and then NL2 peptide was coupled on the surface of polymer‐coated luminescent nanoparticles. Next, the capability of the modified drug was examined by in vitro and in vivo experiments. MTT assay on SK‐BR‐3 cell line (as breast cancer cells) and fluorescent microscopy results indicate that this modification decreases significantly drug toxicity and increases its selectivity. In addition, in vivo experiments confirm more capability of the NL2‐functionalized nanocomposite for reducing tumor size, drug distribution in the body, and more aggregation of PTX in tumor tissue. Overall, it is concluded that tumor imaging is possible using luminescent LaVO4:Eu3+ core and NL2 peptide increases significantly the specificity of PTX in combination with a functionalized luminescent polymeric carrier.

show abstract

“…Mathew et al, prepared CDs from chitosan and prepared chitosan/carbon dot‐ based nanocomposite. The result from the study showed that the prepared nanocomposite can be used as a carrier for dopamine for neurodegenerative disease [62] . Chung et al, prepared carbon dots/hydroxyapatite nanocomposite as a drug carrier for acetaminophen.…”

Section: Biomass‐derived Graphene‐based Nanocomposites In Biomedical Applicationsmentioning

confidence: 99%

Biomass‐Derived Graphene‐Based Nanocomposites: A Futuristic Material for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

Advanced research in the field of material science and biomedicine leads to the development of materials that are efficient and cost‐effective. Graphene has been a widely studied material in recent years and graphene‐based materials exhibit exceptional properties that can be used for applications ranging from biomedical to electronics. In biomedical field, graphene‐based materials are employed in drug delivery, sensing, bioimaging and tissue engineering. However, the production of graphene from graphite and chemical precursors has certain drawbacks such as toxicity, expensive, complex fabrication process, etc. To overcome these, biomass have become a new source for graphene materials. Different types of biomass sources and various preparation methods for graphene‐based materials were reviewed. Here, the applications of biomass derived graphene‐based materials in biomedical field were discussed.

show abstract

Luminescent chitosan/carbon dots as an effective nano-drug carrier for neurodegenerative diseases

Abstract: Facile preparation of carbon dots and a chitosan nanocomposite embedded with carbon dots to encapsulate dopamine and ensure biocompatibility and bioavailability.

Cited by 61 publications

References 50 publications

Natural carbon-based quantum dots and their applications in drug delivery: A review

Natural carbon-based quantum dots and their applications in drug delivery: A review

Targeted delivery of paclitaxel by NL2 peptide‐functionalized on core‐shell LaVO4: Eu3@ poly (levodopa) luminescent nanoparticles

Biomass‐Derived Graphene‐Based Nanocomposites: A Futuristic Material for Biomedical Applications

Contact Info

Product

Resources

About