Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Ranjan, Shashi; Jayakumar, Muthu Kumara Gnanasammandhan; Zhang, Yong

doi:10.2217/nnm.14.229

Cited by 37 publications

(22 citation statements)

References 62 publications

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“…A great number of optically active functional materials is based on the Ln 2+/3+ , because of their unique spectroscopic properties, such as multicolor photoluminescence induced by UV or near‐infrared (NIR) (energy up‐conversion) irradiation, narrow absorption/emission bands, large spectral shift of the emission bands in relation to the absorption ones, long emission lifetimes, etc . Matrices hosting Ln 3+ ions are usually fluorides, oxides, vanadates, phosphates, and borates .…”

Section: Introductionsupporting

confidence: 56%

Optical Vacuum Sensor Based on Lanthanide Upconversion—Luminescence Thermometry as a Tool for Ultralow Pressure Sensing

Runowski

Woźny

Lis

et al. 2020

Adv Materials Technologies

120

103

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the measured spectroscopic parameter is usually a pressure-induced line shift, i.e., spectral shift of the emission bands of Cr 3+ (ruby) or Sm 2+ . [14,15,20,22] Whereas, in the case of temperature the commonly measured parameter is the luminescence intensity ratio (LIR), i.e., band ratio of two thermally coupled levels (TCLs; separated by ≈200-2000 cm −1 ) of, e.g., Nd 3+ , Er 3+ , or Tm 3+ , which is directly related to the local temperature of the system (probe), and conforms Boltzmann distribution. [3,[23][24][25] A great number of optically active functional materials is based on the Ln 2+/3+ , because of their unique spectroscopic properties, such as multicolor photoluminescence induced by UV or near-infrared (NIR) (energy up-conversion) irradiation, narrow absorption/emission bands, large spectral shift of the emission bands in relation to the absorption ones, long emission lifetimes, etc. [26][27][28][29][30][31][32][33][34][35] Matrices hosting Ln 3+ ions are usually fluorides, oxides, vanadates, phosphates, and borates. [3,4,11,12,[19][20][21][22][23][24][25][26] This is mainly because of their resistance to photobleaching and high temperature treatment, as well as relatively low phonon energy in contrast to organic compounds. [3][4][5][19][20][21][22][23][24][25][26] Moreover, the Ln 3+ -doped inorganic materials may exhibit up-conversion (UC) phenomena, i.e., anti-Stokes emission of higher-energy photons, generated by the absorption of two or more lowerenergy photons. [32,[36][37][38][39] Thanks to the high absorption cross-section of Yb 3+ in the NIR range, and the presence of a ladder-like structure of Ln 3+ energy levels, the upconverting materials codoped with Yb 3+ / Ln 3+ (Ln 3+ = Ho 3+ , Er 3+ , Tm 3+ ) may work not only as temperature sensors, but also as optical "heaters," as during their irradiation with a high-power NIR lasers they locally heat up. [40][41][42][43][44][45][46][47][48] This is due to the occurrence of various nonradiative processes between the Ln 3+ ions, quenching luminescence of the material and leading to heat generation. [43][44][45][46][47][48] Thanks to the efficient light-to-heat conversion, the optical heating phenomenon can be utilized in photothermal therapies, thermophotovoltaics, formation of new materials under extreme conditions, etc. [43][44][45][46][47][48][49] Currently, temperature of the system can be optically monitored in a relatively broad range, starting from cryogenic up to around ≈10 3 K, whereas pressure could be monitored only in the "high-pressure" range (≈10 2 -10 6 bar). These limitations are associated with the fundamental concept of pressure sensing, i.e., measurements of physical parameters directly Currently the lowest optically determinable pressure values are around 10 2 bar, making the pressure below inaccessible for optical detection. This work shows for the first time how to overcome these limitations, and optically monitor the low pressure values in a vacuum region (from ≈10 −5 to 10 −2 bar), utilizing the light-induced and pressure-g...

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Section: Introductionsupporting

confidence: 56%

Optical Vacuum Sensor Based on Lanthanide Upconversion—Luminescence Thermometry as a Tool for Ultralow Pressure Sensing

Runowski

Woźny

Lis

et al. 2020

Adv Materials Technologies

120

103

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“…Nanotechnology is a field involving manipulation of materials on the nanometer scale, which encompasses scientific principles adopted in this process, as well as newly discovered properties of matter at such dimensions (Siegrist, Wiek, Helland, & Kastenholz, 2007). With its promising future, nanotechnology has often been dubbed “the next big thing” expected to revolutionize the world we live in, global economy, and daily life (Godwin et al, 2015), because NMs offer various practical applications in diverse fields including but not limited to medicine (e.g., drug delivery, tumor detection and treatment, imaging, and antibacterial agents), electronics, sunblock, paintings, industry, cosmetics, and food preservation (Corma, Atienzar, García, & Chane‐Ching, 2004; Li, Xu, Chen, & Chen, 2011; Murthy, 2007; Ranjan, Jayakumar, & Zhang, 2015; Sato, Katakura, Yin, Fujimoto, & Yabe, 2004; Snyder‐Talkington, Qian, Castranova, & Guo, 2012; Yohan & Chithrani, 2014; Zhao & Castranova, 2011). Future Markets estimates the 2020 worldwide production of NMs to be 21,713 tons (http://www.researchandmarkets.com), with the revenue from nanotechnology‐enabled products totaling $731 billion in 2012 alone (Lux Research, 2014).…”

Section: Introductionmentioning

confidence: 99%

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Demir

2020

J of Applied Toxicology

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Nanomaterials (NMs) generally display fascinating physical and chemical properties that are not always present in bulk materials; therefore, any modification to their size, shape, or coating tends to cause significant changes in their chemical/physical and biological characteristics. The dramatic increase in efforts to use NMs renders the risk assessment of their toxicity highly crucial due to the possible health perils of this relatively uncharted territory. The different sizes and shapes of the nanoparticles are known to have an impact on organisms and an important place in clinical applications. The shape of nanoparticles, namely, whether they are rods, wires, or spheres, is a particularly critical parameter to affect cell uptake and site-specific drug delivery, representing a significant factor in determining the potency and magnitude of the effect. This review, therefore, intends to offer a picture of research into the toxicity of different shapes (nanorods, nanowires, and nanospheres) of NMs to in vitro and in vivo models, presenting an in-depth analysis of health risks associated with exposure to such nanostructures and benefits achieved by using certain model organisms in genotoxicity testing. Nanotoxicity experiments use various models and tests, such as cell cultures, cores, shells, and coating materials. This review article also attempts to raise awareness about practical applications of NMs in different shapes in biology, to evaluate their potential genotoxicity, and to suggest approaches to explain underlying mechanisms of their toxicity and genotoxicity depending on nanoparticle shape.

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“…Metal-based systems are comparatively smaller (1–2 nm), and often possess excellent optical properties such as high brightness, narrow emission bands, multiple emission wavelengths, emission tunability, long fluorescence lifetime, large Stokes shift, resistance to photobleaching, and high stability, compared with other fluorophores (Baird et al, 2000; Shaner et al, 2004; Ranjan et al, 2015). Due to all these properties, especially small size, the position of these dyes in a sample can be determined with high precision, a useful feature to perform super-resolution microscopy (Thompson et al, 2002; Agrawal et al, 2013; Haas et al, 2014).…”

Section: Luminescent Markers For Fluorescence Microscopymentioning

confidence: 99%

Rhenium (I) Complexes as Probes for Prokaryotic and Fungal Cells by Fluorescence Microscopy: Do Ligands Matter?

et al. 2019

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Re(I) complexes have exposed highly suitable properties for cellular imaging (especially for fluorescent microscopy) such as low cytotoxicity, good cellular uptake, and differential staining. These features can be modulated or tuned by modifying the ligands surrounding the metal core. However, most of Re(I)-based complexes have been tested for non-walled cells, such as epithelial cells. In this context, it has been proposed that Re(I) complexes are inefficient to stain walled cells (i.e., cells protected by a rigid cell wall, such as bacteria and fungi), presumably due to this physical barrier hampering cellular uptake. More recently, a series of studies have been published showing that a suitable combination of ligands is useful for obtaining Re(I)-based complexes able to stain walled cells. This review summarizes the main characteristics of different fluorophores used in bioimage, remarking the advantages of d 6 -based complexes, and focusing on Re(I) complexes. In addition, we explored different structural features of these complexes that allow for obtaining fluorophores especially designed for walled cells (bacteria and fungi), with especial emphasis on the ligand choice. Since many pathogens correspond to bacteria and fungi (yeasts and molds), and considering that these organisms have been increasingly used in several biotechnological applications, development of new tools for their study, such as the design of new fluorophores, is fundamental and attractive.

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Luminescent Lanthanide Nanomaterials: An Emerging Tool for Theranostic Applications

Cited by 37 publications

References 62 publications

Optical Vacuum Sensor Based on Lanthanide Upconversion—Luminescence Thermometry as a Tool for Ultralow Pressure Sensing

Optical Vacuum Sensor Based on Lanthanide Upconversion—Luminescence Thermometry as a Tool for Ultralow Pressure Sensing

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Rhenium (I) Complexes as Probes for Prokaryotic and Fungal Cells by Fluorescence Microscopy: Do Ligands Matter?

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