Luminescent Nanomaterials Doped with Rare Earth Ions and Prospects for Their Biomedical Applications (A Review)

Бажукова, И. Н.; Пустоваров, В. А.; Myshkina, A. V.; Улитко, М. В.

doi:10.1134/s0030400x20120875

Cited by 15 publications

(8 citation statements)

References 188 publications

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“…Homogeneous assay is a liquid‐phase assay where the hybridization from cognition process between probes and targets to signal readout is completed in the solution, which is a rapid detection method with no need for separation and tedious washing process. [ 88 ] In this system, the majority of functionalized‐UCNPs usually act as donors to transfer the energy to adjacent modified‐acceptors by the base pairs complementary principle or antigen‐antibody recognition mechanism when adding viral targets. [ 89 , 90 , 91 ] The system's detecting capabilities are demonstrated by the quenching efficiency at varying concentrations of targets.…”

Section: Uc Bioassay For the Detection Of Virusmentioning

confidence: 99%

Advances in upconversion luminescence nanomaterial‐based biosensor for virus diagnosis

Song

et al. 2022

Exploration

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Various infectious viruses have been posing a major threat to global public health, especially SARS‐CoV‐2, which has already claimed more than six million lives up to now. Tremendous efforts have been made to develop effective techniques for rapid and reliable pathogen detection. The unique characteristics of upconversion nanoparticles (UCNPs) pose numerous advantages when employed in biosensors, and they are a promising candidate for virus detection. Herein, this Review will discuss the recent advancement in the UCNP‐based biosensors for virus and biomarkers detection. We summarize four basic principles that guide the design of UCNP‐based biosensors, which are utilized with luminescent or electric responses as output signals. These strategies under fundamental mechanisms facilitate the enhancement of the sensitivity of UCNP‐based biosensors. Moreover, a detailed discussion and benefits of applying UCNP in various virus bioassays will be presented. We will also address some obstacles in these detection techniques and suggest routes for progress in the field. These progressions will undoubtedly pose UCNP‐based biosensors in a prominent position for providing a convenient, alternative approach to virus detection.

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Section: Uc Bioassay For the Detection Of Virusmentioning

confidence: 99%

Advances in upconversion luminescence nanomaterial‐based biosensor for virus diagnosis

Song

et al. 2022

Exploration

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“…[15] Lanthanide ions, such as Yb 3 + , can absorb NIR photons, they are photostable, and their excited states are long-lived. [15][16][17] Cooperative luminescence (CL) occurs upon simultaneous NIRexcitation of two close-lying Yb 3 + ions, thus leading to an upconverted quasi-virtual **Yb 2 excited state, which can emit one photon with almost twice the energy (Figure 1a). [18][19][20][21] Alternatively, when other lanthanide acceptor, such as Tb 3 + , is present in the structure, the **Yb 2 excited state can sensitize the acceptor luminescence via a cooperative sensitization (CS) mechanism (Figure 1b).…”

Section: Introductionmentioning

confidence: 99%

“…Lanthanide ions, such as Yb 3+ , can absorb NIR photons, they are photostable, and their excited states are long‐lived [15–17] . Cooperative luminescence (CL) occurs upon simultaneous NIR‐excitation of two close‐lying Yb 3+ ions, thus leading to an upconverted quasi‐virtual **Yb 2 excited state, which can emit one photon with almost twice the energy (Figure 1a).…”

Section: Introductionmentioning

confidence: 99%

Cooperative Sensitization Upconversion in Ytterbium(III)‐Based Eosin Lake Pigments

Cevallos‐Toledo,

Bellezza,

Ferrera‐González

et al. 2023

ChemPhotoChem

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Materials based on organic chromophores and lanthanides able to transform low‐energy photons, specifically near‐infrared (NIR) photons, into higher energy photons to eventually lead to long‐lived sensitized emission of the dye are highly desirable. Cooperative sensitization (CS) upconversion has only been accomplished for lanthanide‐based clusters. We used here the eosin Y (EOS) dianion and Yb3+ (EOS‐Yb), and demonstrate the efficient CS emission of the dye after NIR excitation. Remarkably, the EOS dianion emission exhibits a nearly linear dependence on the EOS‐Yb concentration and a quadratic dependence on the laser power density. The emission is non‐sensitive to oxygen and its lifetime lasts about 1.76 μs and 12 μs in DMSO and DMSO‐d6, respectively. Moreover, the effect of temperature (293–363 K range) on the EOS‐Yb 1H NMR spectroscopic shifts demonstrates the reversible dynamic nature of the material.

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“…In this work, phosphors based on fluoride host doped with rare-earth ions are used. This class of materials has a high chemical stability, mechanical strength, sufficiently high melting point, relatively low probability of non-radiative processes [7], high quantum yield of luminescence [8], and low toxicity [9]. It should also be noted, that the modern methods of synthesis allows obtaining fluoride phosphors with desirable morphology and structure [10].…”

Section: Introductionmentioning

confidence: 99%

Nd3+, Yb3+:YF3 Optical Temperature Nanosensors Operating in the Biological Windows

et al. 2022

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This work is devoted to the study of thermometric performances of Nd3+ (0.1 or 0.5 mol.%), Yb3+ (X%):YF3 nanoparticles. Temperature sensitivity of spectral shape is related to the phonon-assisted nature of energy transfer (PAET) between Nd3+ and Yb3+). However, in the case of single-doped Nd3+ (0.1 or 0.5 mol.%):YF3 nanoparticles, luminescence decay time (LDT) of 4F3/2 level of Nd3+ in Nd3+ (0.5 mol.%):YF3 decreases with the temperature decrease. In turn, luminescence decay time in Nd3+ (0.1 mol.%):YF3 sample remains constant. It was proposed, that at 0.5 mol.% the cross-relaxation (CR) between Nd3+ ions takes place in contradistinction from 0.1 mol.% Nd3+ concentration. The decrease of LDT with temperature is explained by the decrease of distances between Nd3+ with temperature that leads to the increase of cross-relaxation efficiency. It was suggested, that the presence of both CR and PAET processes in the studied system (Nd3+ (0.5 mol.%), Yb3+ (X%):YF3) nanoparticles provides higher temperature sensitivity compared to the systems having one process (Nd3+ (0.1 mol.%), Yb3+ (X%):YF3). The experimental results confirmed this suggestion. The maximum relative temperature sensitivity was 0.9%·K−1 at 80 K.

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Luminescent Nanomaterials Doped with Rare Earth Ions and Prospects for Their Biomedical Applications (A Review)

Cited by 15 publications

References 188 publications

Advances in upconversion luminescence nanomaterial‐based biosensor for virus diagnosis

Advances in upconversion luminescence nanomaterial‐based biosensor for virus diagnosis

Cooperative Sensitization Upconversion in Ytterbium(III)‐Based Eosin Lake Pigments

Nd3+, Yb3+:YF3 Optical Temperature Nanosensors Operating in the Biological Windows

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