Luminescent properties of LuPO 4 -Pr and LuPO 4 -Eu nanoparticles

Vistovskyy, V.; Malyi, T.; Vaskiv, A.; Chylii, Maksym; Mitina, Nataliya; Zaichenko, Alexander; Gektin, A.; Voloshinovskii, А.

doi:10.1016/j.jlumin.2016.07.064

Cited by 22 publications

(15 citation statements)

References 16 publications

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“…Synthesis of Pr 3+ ‐Doped LuPO 4 Sub‐Microscale Particles : Sub‐microscale powders with the same dopant concentrations were synthesized with a modified sedimentation nucleation method described by Vistovsky . Briefly, LuCl 3 ∙7H 2 O (99.99%, Jiaton) and Pr(NO 3 ) 3 (99.9%, Sigma‐Aldrich) were dissolved in H 2 O (81 mL).…”

Section: Methodsmentioning

confidence: 99%

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Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Espinoza

Volhard

Kätker

et al. 2018

Part & Part Syst Charact

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Pr3+‐doped LuPO4 emits UV radiation between 225 and 280 nm, where DNA shows strong absorption bands. Therefore, a systematic study of the luminescence of Pr3+ doped LuPO4 is performed: Different doping concentrations, particles sizes, and excitation schemes (vacuum UV at 160 nm and X‐rays 50 kV, 2 mA, tungsten target) are compared. The emission spectra in the UV range depends on the excitation energy and the particle size. Microcrystalline particles (6 µm) comprising 1% Pr3+ display the highest emission intensity at 234 nm upon vacuum UV as well as X‐ray excitation. Sub‐microscale particles (20–50 nm) of LuPO4:Pr3+ (1%) show the same UV emission under X‐ray excitation as the larger particles but do not emit under vacuum UV excitation. Colloidal nanoscale particles (5 nm) do not show emission in the UV‐C range. Based on the high‐density and strong X‐ray absorption of LuPO4, the implementation of Pr3+ doped LuPO4 particles of suitable size (20–50 nm) could improve the well‐established radiation therapy. Owing to the strong absorption and low penetration depth of UV‐C radiation in biological tissue, Pr3+‐doped LuPO4 particles located directly in cancerous tumors could allow for additional treatment with cell‐damaging UV‐C radiation.

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Section: Methodsmentioning

confidence: 99%

“…A wide range of techniques for synthesizing different types of nanoparticles with different dopants such as europium, cerium, terbium, and erbium are described in the literature . However, the use of Pr 3+ as a dopant is more limited, in particular monodisperse and colloidal LuPO 4 :Pr 3+ nanoparticles have not been reported …”

Section: Introductionmentioning

confidence: 99%

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Espinoza

Volhard

Kätker

et al. 2018

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“…While the aforementioned principles still apply, nanoparticle scintillators have their own sets of rules for synthesis and luminescent properties. Nanomaterials have expanded the possibilities for X-ray luminescence uses in high-energy physics and medical imaging, providing a large portfolio of compositions including composite films, vitroceramics, thin films, coordination compounds, metal-organic frameworks (MOFs), and organic-inorganic hybrid materials (Cooper, Bekah, & Nadeau, 2014;Hamieh, Dorkenoo, Taupier, Henry, & Halley, 2017;Pereira, Martin, Levinta, & Dujardin, 2015;Vistovskyy et al, 2014;Vistovskyy et al, 2016;Wahid, Pokhrel, & Mao, 2017). Even pure metals and semiconductors, which usually do not function as X-ray scintillators, may function as such if formed into nanoparticles (Brus, 1984;Paillard et al, 1999;Yuan et al, 2013).…”

Section: This Article Is Categorized Undermentioning

confidence: 99%

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Cline

Delahunty

Xie

2018

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X-ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest. This can be achieved by external beam irradiation and using a nanoparticle scintillator as transducer. Alternatively, research on exploiting Cherenkov radiation from radioisotopes to activate PDT has also begun to flourish. In either approach, the most auspicious success is achieved using nanoparticles as either a scintillator or a photosensitizer to mediate energy transfer and radical production. Both X-ray induced PDT (X-PDT) and Cherenkov radiation PDT (CR-PDT) contain a significant radiation therapy (RT) component and are essentially PDT and RT combination. Unlike the conventional combination, however, in X-PDT and CR-PDT, one energy source simultaneously activates both processes, making the combination always in synchronism and the synergy potential maximized. While still in early stage of development, X-PDT and CR-PDT address important issues in the clinic and hold great potential in translation. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

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“…The nanoscale scintillators were synthesized by using a modified sedimentation nucleation method previously used for Pr 3+ ‐doped LuPO 4 NPs as illustrated in Figure S4 in the Supporting Information . The resulting particles were characterized as described in the Experimental Section and representative results for the nanoscale sample LuPO 4 :Pr 3+ ,Nd 3+ (1%,2.5%) (blue) are presented and compared to microscale LuPO 4 :Pr 3+ ,Nd 3+ (red) with the same dopant concentrations in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Synthesis of Pr 3+ ,Nd 3+ Co‐Doped LuPO 4 NPs : The nanoscale scintillators were synthesized with a sedimentation nucleation method, introduced by Vistovsky et al and modified by other groups . LuCl 3 ∙7H 2 O (99.99%, Jiaton), Pr(NO 3 ) 3 (99.9%, Sigma‐Aldrich), and Nd(NO 3 ) 3 (99.9%, Sigma‐Aldrich) (18 mmol) were dissolved in water (81 mL).…”

Section: Methodsmentioning

confidence: 99%

Characterization of Micro‐ and Nanoscale LuPO₄:Pr³⁺,Nd³⁺ with Strong UV‐C Emission to Reduce X‐Ray Doses in Radiation Therapy

Espinoza

Müller

Jenneboer

et al. 2019

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UV‐C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X‐rays during radiation therapy, due to the lethal DNA lesions caused by UV‐C photons. Unfortunately, nanoscale particles (NPs) show decreased UV‐C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV‐C emission of micro‐ and nanoscale LuPO4:Pr3+ is investigated upon X‐ray irradiation and vacuum UV excitation (160 nm). Co‐doped LuPO4 results in increased UV‐C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV‐C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X‐ray irradiation. Finally, LuPO4 NPs co‐doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X‐rays and UV‐C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X‐rays alone due to the formation of UV‐specific DNA damages, supporting the feasibility of this approach.

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Luminescent properties of LuPO 4 -Pr and LuPO 4 -Eu nanoparticles

Cited by 22 publications

References 16 publications

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Characterization of Micro‐ and Nanoscale LuPO₄:Pr³⁺,Nd³⁺ with Strong UV‐C Emission to Reduce X‐Ray Doses in Radiation Therapy

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Luminescent properties of LuPO 4 -Pr and LuPO 4 -Eu nanoparticles

Cited by 22 publications

References 16 publications

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO4:Pr3+

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO4:Pr3+

Nanoparticles to mediate X‐ray‐induced photodynamic therapy and Cherenkov radiation photodynamic therapy

Characterization of Micro‐ and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV‐C Emission to Reduce X‐Ray Doses in Radiation Therapy

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Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Deep Ultraviolet Emitting Scintillators for Biomedical Applications: The Hard Way of Downsizing LuPO₄:Pr³⁺

Characterization of Micro‐ and Nanoscale LuPO₄:Pr³⁺,Nd³⁺ with Strong UV‐C Emission to Reduce X‐Ray Doses in Radiation Therapy