Lunar Laser Ranging (LLR) measurements are crucial for advanced exploration of the laws of fundamental gravitational physics and geophysics as well as for future human and robotic missions to the Moon. The corner-cube reflectors (CCR) currently on the Moon require no power and still work perfectly since their installation during the project Apollo era. Current LLR technology allows us to measure distances to the Moon with a precision approaching 1 millimeter. As NASA pursues the vision of taking humans back to the Moon, new, more precise laser ranging applications will be demanded, including continuous tracking from more sites on Earth, placing new CCR arrays on the Moon, and possibly installing other devices such as transponders, etc. for multiple scientific and technical purposes. Since this effort involves humans in space, then in all situations the accuracy, fidelity, and robustness of the measurements, their adequate interpretation, and any products based