Lunasin Attenuates Obesity-Associated Metastasis of 4T1 Breast Cancer Cell through Anti-Inflammatory Property

Hsieh, Chia Chien; Wang, Chih Hsuan; Huang, Yu

doi:10.3390/ijms17122109

Cited by 31 publications

(27 citation statements)

References 39 publications

(63 reference statements)

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“…Similar effects have been reported in breast cancer cells lines in which lunasin treatment suppresses cell migration and invasion by inhibiting matrix metalloproteinases . Moreover, this anti‐metastasis property of lunasin has also been demonstrated to modestly inhibit the angiogenesis‐mediator vascular endothelial growth factor (VEGF) in 4 T1 breast cancer cell . These results suggested the ability of lunasin to act as an anti‐metastatic agent contributing on its chemopreventive effects.…”

Section: Cancer Chemopreventive and Therapeutic Properties Of Lunasinsupporting

confidence: 73%

“…65 Moreover, this anti-metastasis property of lunasin has also been demonstrated to modestly inhibit the angiogenesis-mediator vascular endothelial growth factor (VEGF) in 4 T1 breast cancer cell. 66 These results suggested the ability of lunasin to act as an anti-metastatic agent contributing on its chemopreventive effects.…”

Section: Lunasin Modulates Cell Growth and Apoptosismentioning

confidence: 93%

“…96 Moreover, lunasin's anti-inflammatory activity possibly benefits its chempreventive activity in 4 T1 breast cancer cell cultured in the condition of inflammatory adipocyte. 66 The inhibition of NF-B-dependent inflammatory mediators through down-regulation of Akt phosphorylation and p65 protein expression was observed after treating human LPS-challenged THP-1 macrophages with lunasin. 97 The peptide interacted with V 3 integrin receptor, being internalised by cells where it exerts its anti-inflammatory effects.…”

Section: Antioxidant and Anti-inflammatory Activitiesmentioning

confidence: 98%

“…Recently, it has been revealed that lunasin acts as a potential anti‐inflammatory agent not only in macrophages but also in adipocytes, disrupting the cross‐talk between these two cells, suggested that auxiliary prevention or therapy in obesity‐related inflammatory applications . Moreover, lunasin's anti‐inflammatory activity possibly benefits its chempreventive activity in 4 T1 breast cancer cell cultured in the condition of inflammatory adipocyte …”

Section: Other Bioactivities Of Lunasinmentioning

confidence: 99%

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Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

et al. 2017

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Chronic diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Modulation of diet and lifestyle habits is considered as the best strategy for the prevention of these disorders. Health promoting benefits beyond their nutritional effects have been described for multiple dietary compounds. Among these compounds, the peptide lunasin is considered as one of the most promising. Naturally present in soybean, lunasin has been extensively studied in the last two decades because of its potential against chronic diseases such as cancer, cardiovascular and immunological disorders. The purpose of this article is to summarise the evidence on the presence of lunasin in soybean and derived foods, and its bioavailability once it is orally ingested. The protective and therapeutic effects of this peptide against cancer, oxidative stress, inflammation, and high cholesterol levels as well as the molecular mechanisms of action involved in these effects are also described in this review. © 2017 Society of Chemical Industry.

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Section: Cancer Chemopreventive and Therapeutic Properties Of Lunasinsupporting

confidence: 73%

Section: Lunasin Modulates Cell Growth and Apoptosismentioning

confidence: 93%

Section: Antioxidant and Anti-inflammatory Activitiesmentioning

confidence: 98%

Section: Other Bioactivities Of Lunasinmentioning

confidence: 99%

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Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

et al. 2017

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“…In addition, lunasin reduces production of proinflammatory cytokines, nitric oxide, and cyclooxygenase‐2 and suppresses NF‐κB signalling through down‐regulation of Akt phosphorylation and p65 protein expression in THP‐1 cells stimulated with LPS. Moreover, in obesity‐related models, lunasin plays an effective anti‐metastasis role in breast cancer cells and disrupts the cross‐talk between macrophages and adipocytes; these data support the application of lunasin against obesity‐related inflammatory diseases (Hsieh et al ., , ). Both bioactivities of lunasin contribute to chemoprevention and act against various chronic diseases.…”

Section: The Chemopreventive Property Of Soy Proteins and Peptidesmentioning

confidence: 99%

Chemoprevention by means of soy proteins and peptides – current status and future approaches: a review

Chen

Hsieh

2018

Int J of Food Sci Tech

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Epidemiological studies have shown that soy consumption is associated with lower incidence of various diseases, such as cancer. Over the past decades, soy proteins and derived peptides have been considered as potential preventive agents against the initiation, promotion and progression of cancer. Additionally, soybeans provide essential nutrients and abundant peptides and proteins with multiple bioactivities. Here, we specifically emphasise the chemoprevention property of several soy proteins/peptides, such as lectins, lunasin and protease inhibitors. Moreover, their anti-inflammatory and antioxidant properties, which have been demonstrated to be associated with chemopreventive properties, are addressed here. Furthermore, computational methods applied in this field are reviewed. Researchers navigate a large volume of data to understand the interactions among the genome, cellular molecules, dietary interventions, medical treatments and diseases. Numerous powerful tools have been recommended for designing an optimal strategy for future anti-cancer treatments with precise diagnosis and individualised approaches.

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Lunasin Peptide is a Modulator of the Immune Response in the Human Gastrointestinal Tract

Fernández-Tomé

Indiano-Romacho

Mora-Gutiérrez

et al. 2021

Molecular Nutrition Food Res

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Introduction Lunasin is a soybean bioactive peptide with a variety of beneficial properties against chronic disorders. However, its effect in human primary intestinal cells remains unknown. Hence, this study aims to characterize its ex vivo biological activity in the human intestinal mucosa. Methods and Results Human intestinal biopsies, obtained from healthy controls, are ex vivo conditioned with lunasin both in the presence/absence of lipopolysaccharide (LPS). Peptide maintains its stability during biopsy culture by HPLC‐MS/MS analysis. Lunasin is bioactive in the human mucosa, as it induces IL‐1β, TNF‐α, IL‐17A, CCL2, and PGE2/COX‐2 gene expression together with an increased expression of tolerogenic IL‐10 and TGFβ, while it also downregulates the expression of iNOS and subunit p65 from NF‐κB. Indeed, lunasin also abrogates the LPS‐induced pro‐inflammatory response, downregulating IL‐17A, IFNγ, and IL‐8 expression, and inducing IL‐10 and TGFβ expression. These results are also mirrored in the cell‐free culture supernatants at the protein level by Multiplex. Moreover, lunasin further induces a regulatory phenotype and function on human intestinal conventional dendritic cell and macrophage subsets as assessed by flow cytometry. Conclusions We hereby have characterized lunasin as an immunomodulatory peptide with potential capacity to prevent immune and inflammatory‐mediated disorders in the human gastrointestinal tract.

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Lunasin Attenuates Obesity-Associated Metastasis of 4T1 Breast Cancer Cell through Anti-Inflammatory Property

Cited by 31 publications

References 39 publications

Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

Updating the research on the chemopreventive and therapeutic role of the peptide lunasin

Chemoprevention by means of soy proteins and peptides – current status and future approaches: a review

Lunasin Peptide is a Modulator of the Immune Response in the Human Gastrointestinal Tract

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