Lung abscess following bronchoscopy due to multidrug-resistant Capnocytophaga sputigena adjacent to lung cancer with high PD-L1 expression

Migiyama, Yohei; Anai, Moriyasu; Kashiwabara, Kosuke; Tomita, Yusuke; Saeki, Sho; Nakamura, Kazuyoshi; Okamoto, Shinichiro; Ichiyasu, Hidenori; Fujii, Kenichi; Kohrogi, Hirotsugu

doi:10.1016/j.jiac.2018.03.017

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…These two bacteria have been found to coexist on the tooth surface and in the pharynx of humans [34]. Within the Y-thin tongue coating bacteria, the representative Y-thin bacterium N. elongata was positively correlated with C. sputigena, a pathogenic species associated with horioamnionitis, abortion, periodontitis, pleuropneumonitis [35,36,37,38] and abscess [39,40], and with the oral cavity resident Lautropia mirabilis [41][42][43][44]. In the Y-thick greasy group, the abundant species P. melaninogenica, V. dispar and Atopobium parvulum were significantly positively correlated with each other, demonstrating the coexistence and potential interactions of these bacteria.…”

Section: Bacterial Correlational Network Within the Tongue Coating Microbiomementioning

confidence: 99%

Microbial characteristics across different tongue coating types in a healthy population

Chen

et al. 2021

Journal of Oral Microbiology

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BackgroundThe physical appearance of tongue coatings is vital for traditional Chinese medicine (TCM) to diagnose health and disease status. The microbiota of different tongue coatings could also influence coating formation and be further associated with specific diseases. Previous studies have focused on bacteria from different tongue coatings in the context of specific diseases, but the normal variations in healthy individuals remain unknown. Aim: We examined the tongue microbiota by metagenomics in 94 healthy individuals classified into eight different tongue types. Results: The overall composition of the tongue coating microbiome is not drastically different among different coating types, similar to the findings of previous studies in healthy populations. Further analysis revealed microbiota characteristics of each coating type, and many of the key bacteria are reported to be implicated in diseases. Moreover, further inclusion of diabetic patients revealed disease-specific enrichment of Capnocytophaga, even though the same tongue coatings were studied. Conclusions: This work revealed the characteristic compositions of distinctive tongue coatings in a healthy population, which serves as a basis for understanding the tongue coating formation mechanism and provides a valuable reference to further investigate diseasespecific tongue coating bacterial markers.

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Section: Bacterial Correlational Network Within the Tongue Coating Microbiomementioning

confidence: 99%

Microbial characteristics across different tongue coating types in a healthy population

Chen

et al. 2021

Journal of Oral Microbiology

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“…C. sputigena has also been involved in a respiratory infection following care; a 67-year-old old man, who underwent fibroscopy for exploration of a suspicious pulmonary mass, presented fever 7 days after the procedure, and a lung abscess was diagnosed. C. sputigena was isolated from the latter and histological analysis detected a lung cancer [5]. Furthermore, C. sputigena was involved in a lung abscess in a 39-year-old immunocompromised host suffering from a neuroendocrine tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, clinical response was correlated with antibiotic susceptibility as the introduction of a beta-lactamase inhibitor improved the clinical course. The bacterium was identified by MALDI-TOF mass spectrometry, which is the technique that has been used in recent case reports [[3], [4], [5]].…”

Section: Discussionmentioning

confidence: 99%

Capnocytophaga sputigena: An unusual cause of community-acquired pneumonia

Gosse

Amrane

Mailhe

et al. 2019

IDCases

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“…His sepsis was due to immunocompromise. Studies have shown that Capnocytophaga bacteremia is associated with severe oral pathology and neutropenia, which can also result in abscess, fulminant sepsis, lung abscess, endocarditis, and meningitis [ 9 – 12 ]. Mortality reaching up to 30% for septicemia and approximately 5% for meningitis has been reported [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Capnocytophaga Induced Acute Necrotizing and Exudative Pericarditis with Abscess Formation

Bello

Castaneda²,

Vakil

et al. 2018

Case Reports in Infectious Diseases

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We present the case of a 55-year-old gentleman, with bilateral pulmonary embolism and a large pericardial effusion that lead to a pericardial window with evacuation of creamy pus. Gram stains were negative, with culture growing Capnocytophaga. Pathology revealed acute necrotizing and exudative changes, including frank abscess formation. In developed countries, pericardial abscess and acute pericarditis are uncommon due to availability of broad-spectrum antibiotics. Pericardial abscess due to Capnocytophaga is even more uncommon.

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Lung abscess following bronchoscopy due to multidrug-resistant Capnocytophaga sputigena adjacent to lung cancer with high PD-L1 expression

Cited by 7 publications

References 19 publications

Microbial characteristics across different tongue coating types in a healthy population

Microbial characteristics across different tongue coating types in a healthy population

Capnocytophaga sputigena: An unusual cause of community-acquired pneumonia

Capnocytophaga Induced Acute Necrotizing and Exudative Pericarditis with Abscess Formation

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