Lung adenocarcinoma presenting as obstructive jaundice: a case report and review of literature

Pericleous, Stephanos; Mukherjee, Samrat Kumar; Hutchins, Robert

doi:10.1186/1477-7819-6-120

Cited by 20 publications

(17 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metastatic lung cancer has a very poor prognosis, especially SCLC, and is usually treated with best supportive care or systemic therapy; nonetheless, several reports in the literature suggest that a survival benefit may be achieved by surgical treatment of solitary extracranial spread of non small cell lung cancer [46,47] . This is confirmed by a recent case report regarding a patient presenting with jaundice subsequently diagnosed with a lung adenocarcinoma with a synchronous single metastatic lesion to the pancreatic head [48] . The patient was subjected first to a pancreaticoduodenectomy and then to the removal of the pulmonary lesion; 18 mo after surgery, the patient is asymptomatic and disease-free.…”

Section: Lung Cancersupporting

confidence: 71%

Pancreatic metastases: An increasing clinical entity

Zerbi¹

2010

WJGS

View full text Add to dashboard Cite

Pancreatic metastases, although uncommon, have been observed with increasing frequency recently, especially by high-volume pancreatic surgery centers. They are often asymptomatic and detected incidentally or during follow-up investigations even several years after the removal of the primary tumor. Renal cell cancer represents the most common primary tumor by far, followed by colorectal cancer, melanoma, sarcoma and lung cancer. Pancreatic metastasectomy is indicated for an isolated and resectable metastasis in a patient fit to tolerate pancreatectomy. Both standard and atypical pancreatic resection can be performed: a resection strategy providing adequate resection margins and maximal tissue preservation of the pancreas should be pursued. The effectiveness of resection for pancreatic metastases is mainly dependent on the tumor biology of the primary cancer; renal cell cancer is associated with the best outcome with a 5-year survival rate greater than 70%.

show abstract

Section: Lung Cancersupporting

confidence: 71%

Pancreatic metastases: An increasing clinical entity

Zerbi¹

2010

WJGS

View full text Add to dashboard Cite

show abstract

“…In the current study, the two patients presented with weight loss. The most common symptoms of pancreatic metastasis from lung cancer that have been reported in the literature are obstructive jaundice and acute pancreatitis (12,13). Z'Graggen et al (6) reported the first case of GI bleeding following solitary metastasis from lung carcinoma in the head of the pancreas in 1998 (6).…”

Section: Discussionmentioning

confidence: 99%

“…However, when patients with solitary metastasis to the pancreas are carefully evaluated and selected, they become candidates for pancreatic resection, with certain patients achieving long-term survival (6,12,19). As in the present cases, the majority of lung cancer patients suffer from widespread disease that is unresectable (20).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

et al. 2015

View full text Add to dashboard Cite

Abstract. The current study presents two cases of gastrointestinal (GI) bleeding due to pancreatic metastasis of non-small cell lung cancer (NSCLC). The two patients had a history of lung adenocarcinoma prior to pancreatic metastasis. The first patient presented with melena, epigastric pain and weight loss, and the second patient presented with melena and weight loss. The diagnoses were confirmed by biopsy of the metastatic lesions. Immunohistochemistry is useful for managing the differential diagnosis between lung cancer and pancreatic carcinoma in patients with a history of lung cancer. Chemotherapy prolonged the survival of the second patient. However, the first patient received no chemotherapy and succumbed to NSCLC six weeks after the diagnosis of metastatic pancreatic cancer. GI bleeding as a result of pancreatic metastasis of NSCLC is extremely rare; including the present two cases, only three cases have been reported in the English literature. The current study is presented in order to increase the awareness of GI hemorrhage as a manifestation of this relatively rare condition.

show abstract

“…Small cell lung carcinoma with pancreatic metastasis has a bad prognosis. However, when patients with solitary metastases to the pancreas are carefully evaluated and selected, they become candidates for pancreatic resection, with certain patients achieving long-term survival [8,15,16]. As in the present case, the majority of lung cancer patients suffer from widespread disease that is unrespectable [5].…”

Section: Discussionmentioning

confidence: 99%

“…Similar to primary pancreatic carcinoma, the majority of symptoms related to the secondary localizations in the pancreas are not organ-specific, including weight loss, fatigue, abdominal or back pain and jaundice and vomiting [7]. The most frequently reported symptoms of pancreatic localizations from lung cancer are obstructive jaundice and acute pancreatitis [8,9]. Thus, early diagnosis of pancreatic metastasis has an important contribution to perform an immediate and appropriate therapy of the disease especially for solitary lesion.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Metastases from a Small Cell Lung Carcinoma: A Case Report

Amaadour¹,

Benbrahim²,

Fz³

et al. 2017

J Cytol Histol

View full text Add to dashboard Cite

BackgroundSmall cell lung carcinomas (SCLC) represent almost 20-25% of all bronchogenic carcinoma and constitutes a group of tumors with high potential of metastases at the time of diagnosis [1,2]. The pancreas is an uncommon site of secondary localization from this neoplasm [3]. Limited data are available concerning incidence, clinical picture, management and prognosis for pancreatic metastases of small cell lung carcinoma. In this paper, we report a case of documented pancreatic involvement due to small cell lung carcinoma and we review the related available literature. Case ReportA 56 year-old man, with a history of smoking (30 pack-years) presented with persistent cough, left chest pain, epigastric tenderness and weight loss. Computed tomography (CT) scan of the chest showed a mediastino-pulmonary mass, 10.6 × 7 cm in size invading adjacent structure with carcinomatosis lymphangit and contralateral pulmonary nodules (Figure 1a and 1b). Bronchoscopy revealed complete stenosis of the apico-posterior segment of the bronchus of the upper left lobe. Trans-bronchial needle Biopsy was positive for neuroendocrine small cell lung carcinoma (Figure 2). CT scan of abdomen and pelvis showed multiple hepatic secondary lesions, bilateral adrenal metastases, peritoneal carcinomatosis and a mass in AbstractThe pancreas is an uncommon site of metastases of small cell lung carcinoma. Pancreatic metastasis occurs toward the end stage of disease. Few cases only were reported in the literature. This case presents a 56 year-old man diagnosed with disseminated small cell lung carcinoma to multiple sites including pancreas. The current paper is presented in order to increase the awareness of this relatively rare condition.

show abstract

Lung adenocarcinoma presenting as obstructive jaundice: a case report and review of literature

Abstract: Background: Lung cancer is known to metastasize to the pancreas with several case reports found in the literature, however, most patients are at an advanced stage and receive palliative treatment.

Cited by 20 publications

References 33 publications

Pancreatic metastases: An increasing clinical entity

Pancreatic metastases: An increasing clinical entity

Gastrointestinal bleeding due to pancreatic metastasis of non-small cell lung cancer: A report of two cases and a literature review

Pancreatic Metastases from a Small Cell Lung Carcinoma: A Case Report

Contact Info

Product

Resources

About