Lung Adenocarcinoma With MUC4 Expression Is Associated With Smoking Status, HER2 Protein Expression, and Poor Prognosis: Clinicopathologic Analysis of 338 Cases

Rokutan‐Kurata, Mariyo; Yoshizawa, Akihiko; Saito, Shinji; Sonobe, Makoto; Menju, Toshi; Momose, Masanobu; Koyama, Mizuki; Shigeto, Shohei; Fujimoto, Masakazu; Zhang, Meng; Morita, Satoshi; Date, Hiroshi; Haga, Hironori

doi:10.1016/j.cllc.2016.11.013

Cited by 27 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we demonstrated that cytoplasmic MUC1 expression was as high as 81.1% in EGFR ‐mutated mucinous adenocarcinomas. MUC4 positivity in lung adenocarcinomas also correlated with poor prognosis possibly due to the epithelial–mesenchymal transition induced by the overexpression of transmembrane mucin and the subsequent disruption of polarity and cell–cell interactions . In our study, the expression rates of MUC1 and MUC4 were higher in the mucinous adenocarcinoma group than those in the nonmucinous adenocarcinoma group.…”

Section: Discussionsupporting

confidence: 54%

Mucinous lung adenocarcinoma, particularly referring to EGFR‐mutated mucinous adenocarcinoma

Wakejima

Inamura

Ninomiya

et al. 2019

Pathology International

View full text Add to dashboard Cite

EGFR-mutated adenocarcinoma. Among 1159 surgically resected invasive adenocarcinomas, 189 mucinous adenocarcinomas (16%) were identified. Among these, 20%, 34% and 9.5% were EGFR mutated, KRAS mutated and ALK rearranged, respectively. Compared with EGFR-mutated nonmucinous adenocarcinoma, EGFR-mutated mucinous adenocarcinoma had no female predominance, lower grades of histological differentiation and lower TTF-1 and higher HNF-4a expressions. Moreover, for the first time, we indicated that mucin production was an independent prognostic factor for EGFR-mutated adenocarcinomas and the mucin-staining pattern of negative MUC5AC and positive MUC5B was characteristic in these adenocarcinomas. We suggest that EGFRmutated mucinous adenocarcinoma has a different tumorigenic pathway than nonmucinous EGFR-mutated adenocarcinoma. K E Y W O R D S adenocarcinoma, EGFR mutation, HNF-4a, KRAS mutation, lung, MUC1, MUC5B, mucin, TTF-1

show abstract

Section: Discussionsupporting

confidence: 54%

Mucinous lung adenocarcinoma, particularly referring to EGFR‐mutated mucinous adenocarcinoma

Wakejima

Inamura

Ninomiya

et al. 2019

Pathology International

View full text Add to dashboard Cite

show abstract

“…Interestingly, miR-532-5p and miR-532-3p, which belong to the same miR-532 family and are included in the enriched “pathways in cancer”, were located close to each other in the interactive network ( Figure 2 B). MUC4, the downregulation of which is associated with tumor progression in EGFR -mutated lung adenocarcinoma, was targeted by three miRNAs: miR-500a-3p, miR-502-3p, and miR-652-3p [ 46 ]. ( Figure 2 B and Supplementary Table S4 ).…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, complex interactions between upregulated miR-500a-3p, miR-502-3p, and miR-652-3p, and downregulated MUC4 were identified in EGFR -mutated tumors. Downregulated MUC4 has been reported to induce tumor progression in conjunction with an EGFR mutation [ 46 ]. Taken together, the concordant results in this and previous studies help identify characteristic oncogenic pathways in EGFR -mutated lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma

Subat

Inamura

Ninomiya

et al. 2018

JCM

View full text Add to dashboard Cite

The EGFR gene was one of the first molecules to be selected for targeted gene therapy. EGFR-mutated lung adenocarcinoma, which is responsive to EGFR inhibitors, is characterized by a distinct oncogenic pathway in which unique microRNA (miRNA)–mRNA interactions have been observed. However, little information is available about the miRNA–mRNA regulatory network involved. Both miRNA and mRNA expression profiles were investigated using microarrays in 155 surgically resected specimens of lung adenocarcinoma with a known EGFR mutation status (52 mutated and 103 wild-type cases). An integrative analysis of the data was performed to identify the unique miRNA–mRNA regulatory network in EGFR-mutated lung adenocarcinoma. Expression profiling of miRNAs and mRNAs yielded characteristic miRNA/mRNA signatures (19 miRNAs/431 mRNAs) in EGFR-mutated lung adenocarcinoma. Five of the 19 miRNAs were previously listed as EGFR-mutation-specific miRNAs (i.e., miR-532-3p, miR-500a-3p, miR-224-5p, miR-502-3p, and miR-532-5p). An integrative analysis of miRNA and mRNA expression revealed a refined list of putative miRNA–mRNA interactions, of which 63 were potentially involved in EGFR-mutated tumors. Network structural analysis provided a comprehensive view of the complex miRNA–mRNA interactions in EGFR-mutated lung adenocarcinoma, including DUSP4 and MUC4 axes. Overall, this observational study provides insight into the unique miRNA–mRNA regulatory network present in EGFR-mutated tumors. Our findings, if validated, would inform future research examining the interplay of miRNAs and mRNAs in EGFR-mutated lung adenocarcinoma.

show abstract

“…The association between GATA6 expression and alterations in EGFR , KRAS , HER2 , BRAF , ALK and ROS1 was evaluated. Mutation analysis was reported in our previous studies …”

Section: Methodsmentioning

confidence: 94%

GATA6‐positive lung adenocarcinomas are associated with invasive mucinous adenocarcinoma morphology, hepatocyte nuclear factor 4α expression, and KRAS mutations

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Lung Adenocarcinoma With MUC4 Expression Is Associated With Smoking Status, HER2 Protein Expression, and Poor Prognosis: Clinicopathologic Analysis of 338 Cases

Cited by 27 publications

References 33 publications

Mucinous lung adenocarcinoma, particularly referring to EGFR‐mutated mucinous adenocarcinoma

Mucinous lung adenocarcinoma, particularly referring to EGFR‐mutated mucinous adenocarcinoma

Unique MicroRNA and mRNA Interactions in EGFR-Mutated Lung Adenocarcinoma

GATA6‐positive lung adenocarcinomas are associated with invasive mucinous adenocarcinoma morphology, hepatocyte nuclear factor 4α expression, and KRAS mutations

Contact Info

Product

Resources

About