Lung adenosquamous carcinoma with lingual and cardiac metastases

Abstract

Metastatic lingual tumors are very rare, and hematogenous myocardial metastasis is also relatively uncommon. We report a case of lung adenosquamous carcinoma with metastases to the tongue and the myocardium. A 65-year-old man underwent a partial upper lobectomy for a primary lung cancer in June 1997. He developed a local recurrence and received two courses of radiotherapy, in March and September 1998. A follow-up computed tomography (CT) scan showed a myocardial tumor, suggestive of cardiac metastasis. In October 1998, he began to complain of anginalike chest oppression and showed ischemic changes on electrocardiogram (ECG), and he also developed lingual, subcutaneous, and brain metastases. He died of respiratory failure in December 1998, 20 months after the initial diagnosis of primary lung cancer; metastases to the tongue and myocardium were confirmed by autopsy.

Metastasis of pulmonary adenocarcinoma to the oral cavity: A case report and literatures review of the last 30 years

“…Several studies have recommended palliative treatment (e.g., surgical treatment, chemotherapy, and radiotherapy) to improve the quality of life (QOL) and to maintain the patient's comfort 7,8 . We found 54 cases of oral metastasis of PCs that were reported from 1991 to 2021 in PubMed and Google scholar 9–45 and reviewed these cases, including our case. Kaplan‐Meier survival analyses were performed to determine whether palliative treatment affected overall survival.…”

“…In our review, 41 of 54 patients received palliative treatments, and surgical treatments were common ( n = 10), followed by chemoradiotherapy ( n = 8) (Table 1). 8–44 There were no significant differences in the survival times between patients with and without palliative treatment at 6.49 and 4.36 months, according to the results of the Kaplan‐Meier test (log rank test: P = 0.437, Figure 4), which suggested that palliative treatment had no effect on survival time. Our patient was able to consume food orally using the upper denture after surgical treatment, showing that even if radical therapy cannot be administered, palliative treatment for maintaining oral function may contribute to the improvement of the QOL.…”