Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina

Hopenhayn‐Rich, Claudia; Biggs, Mary L.; Smith, Allan H.

doi:10.1093/ije/27.4.561

Cited by 431 publications

(197 citation statements)

References 24 publications

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“…iAs is classified as a human carcinogen (IARC, 1987). Numerous epidemiologic studies have associated chronic exposure to iAs with increased prevalence of cancers of the skin, bladder, liver, lung, and stomach (Bates et al, 1995;Bates et al, 1992;Chen et al, 1992;Chen et al, 1985;Chiang et al, 1988;Chiou et al, 1995;Guo et al, 1997;Hopenhayn-Rich et al, 1996;Hopenhayn-Rich et al, 1998;Lewis et al, 1999;Smith et al, 1998;Smith et al, 1992;Tseng et al, 1968;Tsuda et al, 1995;Wu et al, 1989). Previous research of the effects of chronic exposure to iAs has focused primarily on its carcinogenic potential.…”

Section: Introductionmentioning

confidence: 99%

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Paul

Hernández-Zavala

Walton

et al. 2007

Toxicology and Applied Pharmacology

125

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Previous epidemiologic studies found increased prevalences of type 2 diabetes mellitus in populations exposed to high levels of inorganic arsenic (iAs) in drinking water. Although results of epidemiologic studies in low-exposure areas or occupational settings have been inconclusive, laboratory research has shown that exposures to iAs can produce effects that are consistent with type 2 diabetes. The current paper reviews the results of laboratory studies that examined the effects of iAs on glucose metabolism and describes new experiments in which the diabetogenic effects of iAs exposure were reproduced in a mouse model. Here, weanling male C57BL/6 mice drank deionized water with or without the addition of arsenite (25 or 50 ppm As) for 8 weeks. Intraperitoneal glucose tolerance tests revealed impaired glucose tolerance in mice exposed to 50 ppm As, but not to 25 ppm As. Exposure to 25 and 50 ppm As in drinking-water resulted in proportional increases in the concentration of iAs and its metabolites in the liver and in organs targeted by type 2 diabetes, including pancreas, skeletal muscle and adipose tissue. Dimethylarsenic was the predominant form of As in the tissues of mice in both 25 and 50 ppm groups. Notably, the average concentration of total speciated arsenic in livers from mice in the 50 ppm group was comparable to the highest concentration of total arsenic reported in the livers of Bangladeshi residents who had consumed water with an order of magnitude lower level of iAs. These data suggest that mice are less susceptible than humans to the diabetogenic effects of chronic exposure to iAs due to a more efficient clearance of iAs or its metabolites from target tissues.

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Section: Introductionmentioning

confidence: 99%

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Paul

Hernández-Zavala

Walton

et al. 2007

Toxicology and Applied Pharmacology

125

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“…Fortunately, this area is banned and normally no one aware will eat clams collected from there. Contamination of mussels, seafood, and bivalves by toxic metals is frequently reported worldwide these last years in the range of 0.04-4.9 lg/g for Cd, 0.1-0.4 lg/g for Pb, 8-235 lg/g for Cu, and 0.15-0.75 lg/g for Cr (Hopenhayn-Rich et al, 1998;Saavedra et al, 2004;Bebianno et al, 2004;Romeo et al, 2006). Concentrations of heavy metal detected here are clearly higher than the one detected in mussels from the south part of France this last decade for Cd, that is 0.83 lg/g dried weight versus 1.08 lg/g of wet flesh weight, corresponding approximately to 5.4 lg/g of dried weight (Traoré et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…The seafood production area of Boughrara, Tunisia, was banned a year ago because of pollution by heavy metals. Potential sources of toxic metal include groundwater contamination, metal working, leather tanning, and mining (Steenland et al, 1996;Hopenhayn-Rich et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Combined cytotoxicity and genotoxicity of a marine toxin and seafood contaminant metal ions (chromium and cadmium)

Souid-Mensi

Moukha

Maaroufi

et al. 2008

Environmental Toxicology

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Algal bloom with consequent production of marine toxins contaminating bivalves is increasing in costal regions worldwide because of sea water quality worsening. Contamination of seafood by diarrheic shellfish poisoning toxins (DSP) together with metals is frequently reported, a phenomenon not fully explained yet. In this context, metal ions were assayed in clams collected from the banned area of Boughrara, Tunisia, contaminated by Gymnodinium and other algae such as Dinophysis sp, accumulated by these bivalves. The presence of toxic metals ions such as Chromium (Cr) and Cadmium (Cd) in meat, shells, and water released by the clams prompted us to experiment in Caco-2 intestinal cell line toxic effects of these heavy metals ions in combination with okadaic acid, one DSP present in clams to assess the potential global toxicity. Cr and Cd produce additive effects in (i) reactive oxygen species production, (ii) cytotoxicity as assessed by the mitochondrial activity testing method (MTT test), and (iii) DNA lesions evaluated by agarose gel electrophoresis and acridine orange staining. Exaggerated DNA fragmentation is observed, suggesting an overloading of repair capacity of Caco-2 cells. The apoptosis suggested by a DNA fragment sizing (180-200 bp) in agarose gel and mechanisms underlying these additive effects in Caco-2 cells still need to be more comprehensively explained.

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“…Study on the SMR with As exposure from ground water in Argentina revealed dose-related association between As exposure and risk of kidney and lung cancers (Hopenhayn-Rich et al, 1998). The classification for exposure groups was based on estimated As concentration in drinking water such that less than 0.04 mg/L was designated the low group and over than 0.178 mg/L the high group.…”

Section: Internal Malignanciesmentioning

confidence: 99%

Chronic health effects in people exposed to arsenic via the drinking water: dose?response relationships in review

Yoshida¹

2004

Toxicology and Applied Pharmacology

517

266

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Chronic arsenic (As) poisoning has become a world wide public health issue.Most human As exposure occurs from consumption of drinking water containing high amounts of inorganic As (iAs). In this paper, epidemiological studies conducted on the dose-response relationships between iAs exposure via the drinking water and related adverse health effects are reviewed. Before the review, the methods for evaluation of the individual As exposure are summarized and classified into two types, i.e. the methods depending on As concentration of the drinking water and the methods depending on biological monitoring for As exposure; certain methods may be applied as optimum As exposure indexes to study dose-response relationship based on various As exposure situation. Chronic effects of iAs exposure via drinking water include skin lesions, neurological effects, hypertension, peripheral vascular disease, cardiovascular disease, respiratory disease, diabetes mellitus, and malignancies including skin cancer.The skin is quiet sensitive to arsenic and skin lesions are some of the most common and earliest non-malignant effects related to chronic As exposure. The increase of prevalence in the skin lesions has been observed even at the exposure levels in the range of 0.005-0.01 mg/L As in drinking waters. Skin, lung, bladder, kidney, liver and uterus are considered as sites As-induced malignancies, and the skin is though to be perhaps the most sensitive site. Prospective studies in large area of endemic As poisoning, like Bangladesh or China, where the rate of malignancies is expected to increase within the next several decades, will help to clarify the dose-response relationship between As exposure levels and adverse health effects with enhanced accuracy.

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Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina

Abstract: The results add to the evidence that arsenic ingestion increases the risk of lung and kidney cancers. In this study, the association between arsenic and mortality from liver and skin cancers was not clear.

Cited by 431 publications

References 24 publications

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: Development of a mouse model for arsenic-induced diabetes

Combined cytotoxicity and genotoxicity of a marine toxin and seafood contaminant metal ions (chromium and cadmium)

Chronic health effects in people exposed to arsenic via the drinking water: dose?response relationships in review

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