Lung biopsy in immunocompromised hosts

Greenman, Richard L.; Goodall, Patrick T.; King, Donald S.

doi:10.1016/0002-9343(75)90256-9

Cited by 159 publications

(24 citation statements)

References 19 publications

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“…The morbidity in our series was 5.1% (22 patients) which compares favourably with other studies [11,23,29,30]. Wound infection was the most common problem (11 patients) and in each case this was successfully treated with simple wound toilet and antibiotics.…”

Section: Discussionsupporting

confidence: 81%

“…One patient had a myocardial infarct, and in the remaining 11 patients the cause of death was re spiratory failure secondary to the rapid progression of the underlying lung disease; 7 patients were on a ventilator prior to open lung biopsy and 3 patients required intermit tent positive pressure ventilation after the procedure. The poor prognosis of patients with marked pulmonary dys function who require mechanical ventilation has been commented upon by other studies [27,[29][30][31].…”

Section: Discussionmentioning

confidence: 96%

“…The mortality associated with this group of patients in all forms of lung biopsy is well documented and can be as high as 62% [26,[29][30][31][32]. Thus, in patients whose lung function is so severely im paired as to necessitate mechanical ventilation either preor post-operatively, or requiring high-dose corticosteroid therapy, open lung biopsy should be considered as a highrisk procedure.…”

Section: Discussionmentioning

confidence: 99%

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Open Lung Biopsy: A Safe, Reliable and Accurate Method for Diagnosis in Diffuse Lung Disease

Shah

Tsang²,

Goldstraw³

1992

Respiration

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The ideal method for obtaining lung tissue for diagnosis should provide high diagnostic yield with low morbidity and mortality. We reviewed all 432 patients (mean age 55 years) who underwent an open lung biopsy at this hospital over a 10-year period. Twenty-four patients (5.5%) were immunocompromised. One hundred and twenty-five patients were on steroid therapy at the time of operation. Open lung biopsy provided a firm diagnosis in 410 cases overall (94.9%) and in 20 out of 24 patients in the immunocompromised group (83.3%). The commonest diagnosis was cryptogenic fibrosing alveolitis (173 patients). Twenty-two patients (5.1%) suffered complications following the procedure: wound infection 11 patients, pneumothorax 9 patients and haemothorax 1 patient. Thirteen patients (3.0%) died following open lung biopsy, but in only 1 patient was the death attributable to the procedure itself. We conclude that open lung biopsy is an accurate and safe method for establishing a diagnosis in diffuse lung disease with a high yield and minimal risk.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Open Lung Biopsy: A Safe, Reliable and Accurate Method for Diagnosis in Diffuse Lung Disease

Shah

Tsang²,

Goldstraw³

1992

Respiration

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“…Bronchoalveolar lavage and transbronchial biopsy are indicated and useful in high risk patients when the organism has to be identified quickly by smear. However, aggressive approaches to lung biopsy in immunocompromised hosts with 'fever and pulmonary infiltrate' syndromes, expedite diagnosis of fungal pneumonias and may improve the high morbidity and mortality [18][19][20]. In our patient, bronchoscopy could be performed.…”

Section: Discussionmentioning

confidence: 99%

Successfully treated invasive pulmonary aspergillosis in a patient with diabetic ketoacidosis

et al. 2013

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“…The value of OLB in the immunocompromised patient has been evaluated by several studies [50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60]. Specific diagnosis is achieved in 37–85% of the population.…”

Section: Open Lung Biopsymentioning

confidence: 99%