Lung cancer and particulate pollution: A critical review of spatial and temporal analysis evidence

Wang, Ning; Mengersen, Kerrie; Kimlin, Michael G.; Zhou, Maigeng; Tong, Shilu; Fang, Liwen; Wang, Baohua; Hu, Wenbiao

doi:10.1016/j.envres.2018.03.034

Cited by 54 publications

(26 citation statements)

References 37 publications

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“…PM mainly led to diseases related to both respiratory and cardiovascular systems. Fine PM such as PM 1.0 and PM 2.5 penetrate deeply into the lung, irritate and corrode the alveolar wall and, as a result, affect lung functions [ 135 ] and might also result in lung cancer [ 136 ]. However, the deposition of particles in the respiratory tract is only enhanced for particles with many charges, which can only be achieved with an ionizer in an enclosed space.…”

Section: The Release Of Negative Air Ions As An Efficient Way To Rmentioning

confidence: 99%

Negative Air Ions and Their Effects on Human Health and Air Quality Improvement

Jiang

Ramachandran

2018

IJMS

169

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Negative air ions (NAIs) have been discovered for more than 100 years and are widely used for air cleaning. Here, we have carried out a comprehensive reviewing on the effects of NAIs on humans/animals, and microorganisms, and plant development. The presence of NAIs is credited for increasing psychological health, productivity, and overall well-being but without consistent or reliable evidence in therapeutic effects and with controversy in anti-microorganisms. Reports also showed that NAIs could help people in relieving symptoms of allergies to dust, mold spores, and other allergens. Particulate matter (PM) is a major air pollutant that affects human health. Experimental data showed that NAIs could be used to high-efficiently remove PM. Finally, we have reviewed the plant-based NAI release system under the pulsed electric field (PEF) stimulation. This is a new NAI generation system which releases a huge amount of NAIs under the PEF treatment. The system may be used to freshen indoor air and reduce PM concentration in addition to enriching oxygen content and indoor decoration at home, school, hospital, airport, and other indoor areas.

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Section: The Release Of Negative Air Ions As An Efficient Way To Rmentioning

confidence: 99%

Negative Air Ions and Their Effects on Human Health and Air Quality Improvement

Jiang

Ramachandran

2018

IJMS

169

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“…Our established model can predict the component of respirable dust with crystalline silica but cannot separate the RCS into different sizes. Because the smaller particles, such as particulate matter with the aerodynamic equivalent diameter less than 2.5 μm (PM 2.5 ), are reported to have the more serious effects on lung cancer [ 39 , 40 ], the mastersizer system can be further applied to our predictive models in future experiments.…”

Section: Discussionmentioning

confidence: 99%

Determination and Prediction of Respirable Dust and Crystalline-Free Silica in the Taiwanese Foundry Industry

Kuo

Chiu

Bao

et al. 2018

IJERPH

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Background: Respirable crystalline silica (RCS) has been recognized as a human carcinogen; however, the measurement and analysis of RCS in small-scale foundries is rare and difficult. This study aimed to measure respirable dust and RCS levels among 236 foundry workers in Taiwan and used these data to establish predictive models for personal exposure. Methods: Personal sampling of various production processes were measured gravimetrically and analyzed using the X-ray diffraction method. Multiple linear regression was used to establish predictive models. Results: Foundry workers were exposed to geometric means and geometric standard deviations of 0.52 ± 4.0 mg/m3 and 0.027 ± 15 mg/m3 for respirable dust and RCS, respectively. The highest exposure levels were observed among workers in the sand blasting process, with geometric means of 1.6 mg/m3 and 0.099 mg/m3 for respirable dust and RCS, respectively. The predictive exposure model for respirable dust fitted the data well (R2 = 0.75; adjusted R2 = 0.64), and the predictive capacity for RCS was higher (R2 = 0.89; adjusted R2 = 0.84). Conclusions: Foundry workers in the sand blasting process may be exposed to the highest levels of respirable dust and RCS. The developed models can be applied to predict respirable dust and RCS levels adequately in small-scale foundry workers for epidemiological studies.

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“…One day after injection, the mice were sacrificed and bronchoalveolar lavage fluid (BALF) and lung tissue were collected for further study. The intratracheal instillation of PM 2.5 has been previously shown to cause lung damage, including increased vascular permeability, alveolar epithelial dysfunction, and vascular inflammation [14,44]. Thus, administration of PM via intratracheal instillation is a convenient and effective way to induce lung injury in vivo.…”

Section: Animals and Husbandrymentioning

confidence: 99%

“…5 and inflammation has been identified as playing a role in a variety of lung diseases-such as asthma, acute lung injury, and chronic obstructive pulmonary disease-and the secretion of inflammatory cytokines (interleukins (ILs) and tumor necrosis factor (TNF)-α) were induced by PM2.5 [11][12][13]. Because there is a significant correlation between exposure to PM2.5 and the risk of asthma, and also the incidence and mortality of lung cancer [14], there is a high-priority need to develop new prevention and treatment strategies for respiratory diseases.…”

Section: Introductionmentioning

confidence: 99%

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

Lee

Baek

Kim

et al. 2020

IJMS

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The screening of biologically active chemical compound libraries can be an efficient way to reposition Food and Drug Adminstration (FDA)-approved drugs or to discover new therapies for human diseases. Particulate matter with an aerodynamic diameter equal to or less than 2.5 μm (PM2.5) is a form of air pollutant that causes significant lung damage when inhaled. This study illustrates drug repositioning with biapenem (BIPM) for the modulation of PM-induced lung injury. Biapenem was used for the treatment of severe infections. Mice were treated with BIPM via tail-vein injection after the intratracheal instillation of PM2.5. Alterations in the lung wet/dry weight, total protein/total cell count and lymphocyte count, inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), vascular permeability, and histology were monitored in the PM2.5-treated mice. BIPM effectively reduced the pathological lung injury, lung wet/dry weight ratio, and hyperpermeability caused by PM2.5. Enhanced myeloperoxidase (MPO) activity by PM2.5 in the pulmonary tissue was inhibited by BIPM. Moreover, increased levels of inflammatory cytokines and total protein by PM2.5 in the BALF were also decreased by BIPM treatment. In addition, BIPM markedly suppressed PM2.5-induced increases in the number of lymphocytes in the BALF. Additionally, the activity of mammalian target of rapamycin (mTOR) was increased by BIPM. Administration of PM2.5 increased the expression levels of toll-like receptor 4 (TLR4), MyD88, and the autophagy-related proteins LC3 II and Beclin 1, which were suppressed by BIPM. In conclusion, these findings indicate that BIPM has a critical anti-inflammatory effect due to its ability to regulate both the TLR4-MyD88 and mTOR-autophagy pathways, and may thus be a potential therapeutic agent against diesel PM2.5-induced pulmonary injury.

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Lung cancer and particulate pollution: A critical review of spatial and temporal analysis evidence

Cited by 54 publications

References 37 publications

Negative Air Ions and Their Effects on Human Health and Air Quality Improvement

Negative Air Ions and Their Effects on Human Health and Air Quality Improvement

Determination and Prediction of Respirable Dust and Crystalline-Free Silica in the Taiwanese Foundry Industry

Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury

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