Lung Cancer and Risk of Cardiovascular Disease: A Meta-analysis of Cohort Studies

Yuan, Min; Li, Qiugen

doi:10.1053/j.jvca.2017.04.033

Cited by 20 publications

(17 citation statements)

References 11 publications

(12 reference statements)

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“…It also is similar to studies demonstrating that those with high prediagnostic CRF have a lower risk of mortality after a cancer diagnosis . Cancer and cardiovascular disease coexist in many of the same individuals and both can contribute to morbidity and mortality in patients with cancer, with an increased risk of death from cardiovascular disease found among survivors of lung and colorectal cancer . The results of the current study support the idea that clinically obtained cardiac stress testing provides important additional information regarding cancer risk and mortality after cancer diagnosis in a general, clinically referred population.…”

Section: Discussionsupporting

confidence: 88%

“…18,37 Cancer and cardiovascular disease coexist in many of the same individuals and both can contribute to morbidity and mortality in patients with cancer, with an increased risk of death from cardiovascular disease found among survivors of lung and colorectal cancer. [38][39][40][41][42] The results of the current study support the idea that clinically obtained cardiac stress testing provides important additional information regarding cancer risk and mortality after cancer diagnosis in a general, clinically referred population. In addition, although it does not appear that there is a threshold effect in which higher CRF no longer reduces one's risk of lung or colon cancer or all-cause mortality after either of these diagnoses, the nature of the current analysis (ie, categorical) precluded us from appropriately addressing this issue.…”

Section: Discussionsupporting

confidence: 78%

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Cardiorespiratory fitness and incident lung and colorectal cancer in men and women: Results from the Henry Ford Exercise Testing (FIT) cohort

Marshall

Al‐Mallah

Dardari³

et al. 2019

Cancer

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Background To the authors’ knowledge, the relationship between cardiorespiratory fitness (CRF) and lung and colorectal cancer outcomes is not well established. Methods A retrospective cohort study was performed of 49,143 consecutive patients who underwent clinician‐referred exercise stress testing from 1991 through 2009. The patients ranged in age from 40 to 70 years, were without cancer, and were treated within the Henry Ford Health System in Detroit, Michigan. CRF, measured in metabolic equivalents of task (METs), was categorized as <6 (reference), 6 to 9, 10 to 11, and ≥12. Incident cancer was obtained through linkage to the cancer registry and all‐cause mortality from the National Death Index. Results Participants had a mean age of 54 ± 8 years. Approximately 46% were female, 64% were white, 29% were black, and 1% were Hispanic. The median follow‐up was 7.7 years. Cox proportional hazard models, adjusted for age, race, sex, body mass index, smoking history, and diabetes, found that those in the highest fitness category (METs ≥12) had a 77% decreased risk of lung cancer (hazard ratio [HR], 0.23; 95% CI, 0.14‐0.36) and a 61% decreased risk of incident colorectal cancer (HR, 0.39; 95% CI, 0.23‐0.66; with additional adjustment for aspirin and statin use). Among those diagnosed with lung and colorectal cancer, those with high fitness had a decreased risk of subsequent death of 44% and 89%, respectively (HR, 0.56 [95% CI, 0.32‐1.00] and HR, 0.11 [95% CI, 0.03‐0.37], respectively). Conclusions In what to the authors’ knowledge is the largest study performed to date, higher CRF was associated with a lower risk of incident lung and colorectal cancer in men and women and a lower risk of all‐cause mortality among those diagnosed with lung or colorectal cancer.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 78%

Cardiorespiratory fitness and incident lung and colorectal cancer in men and women: Results from the Henry Ford Exercise Testing (FIT) cohort

Marshall

Al‐Mallah

Dardari³

et al. 2019

Cancer

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“…Indeed, in the NLST study, more than 50% of deaths were attributed to CV events [ 1 ]. Smoking is also a major risk factor in CV mortality, thereby explaining the relationship between those pathologies and lung cancer [ 5 , 6 ]. All those findings highlighted the interest of combining organized, low-dose, CT scan lung-cancer screening with a more general search for tobacco-associated diseases [ 7 ], especially targeting chronic obstructive pulmonary disease (COPD) and CV events, aptly called “Big-3” screening [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Impact on All-Cause and Cardiovascular Mortality Rates of Coronary Artery Calcifications Detected during Organized, Low-Dose, Computed-Tomography Screening for Lung Cancer: Systematic Literature Review and Meta-Analysis

Gendarme

Goussault

Assié

et al. 2021

Cancers

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Although organized, low-dose, computed-tomography (CT) scan lung-cancer screening has been shown to lower all-cause and lung-cancer-specific mortality, the primary cause of death for subjects eligible for such screening remains cardiovascular (CV) mortality. This meta-analysis study was undertaken to evaluate the impact of screening-scan-detected coronary artery calcifications (CACs) on CV and all-cause mortality. We conducted a systematic review and meta-analysis of studies reporting CV mortality according to the Agatson CAC score for participants in a lung-cancer screening program of randomized clinical or cohort studies. PubMed, Embase, and Cochrane databases were screened in June 2020. Two authors independently selected articles and extracted data. Six studies, including 20,175 subjects, were retained. CV and all-cause mortality rates were higher for subjects with CAC scores >0, with respective relative risks of 2.02 [95% CI 1.23–3.32] and 2.29 [95% CI 1.00–5.21]. Both mortality rates were even higher for those with high CAC scores (>400 or >1000). CACs are more common in men than in women, with an odds ratio of 1.49 [95% CI 1.40–1.59]. The presence of CAC is associated with CV mortality with an RR of 2.05 [95% CI 1.20–3.57] in men and 2.37 [CI 95% 1.29–5.09] in women, respectively. Analysis of lung-cancer-screening scans for CACs is a tool able to predict CV mortality. Prospective studies within those programs are needed to assess the benefit of primary CV prevention based on CAC detection.

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“…The connecting link between cancer and atherosclerosis is the common molecular pathway and processes such as oxidative stress, inflammation, abnormal apoptosis, uncontrolled cell proliferation, and vasodilation, which are shared by these two multifactorial diseases. More specifically, degradation of cell proliferation, which is exacerbated by oxidative stress, allows not only the development of atherosclerotic plaque but also various types of cancer [27,28].…”

Section: Discussionmentioning

confidence: 99%

Atherosclerotic diseases and lung cancer – a ten-year cross-sectional study in Cyprus

Rethemiotaki

2020

Arch Med Sci Atheroscler Dis

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Introduction: The main purpose of this work is to study atherosclerotic diseases and lung cancer in Cyprus during the period 2007-2017 with the aim of finding not only the atherosclerotic diseases with the highest risk but also a possible association between these diseases and lung cancer. Material and methods: The statistical methods used to extract the results of this work are Student's t-test and one-way analysis of variance (ANOVA), in order to check the statistical significance of atherosclerotic diseases with regard to the characteristics of the patients. Additionally, a multiple logistic regression analysis was used with the aim of finding the disease with the highest risk. Pearson's r was used to find a possible association between atherosclerotic diseases and lung cancer. Results: As specified by multiple logistic regression analysis, the atherosclerotic diseases with the highest risk of death are intracranial haemorrhage (OR = 17.3), heart failure (OR = 3.29), and stroke (OR = 3.02), with females having higher risk compared to men. Moreover, a statistically significant relation was found between heart failure and cerebral infarction with lung cancer. Conclusions: The results of this work highlight the statistically significant characteristics of patients with atherosclerotic diseases and identify the risk of death according to the type of the disease. A link between these diseases and cancer was also identified.

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Lung Cancer and Risk of Cardiovascular Disease: A Meta-analysis of Cohort Studies

Cited by 20 publications

References 11 publications

Cardiorespiratory fitness and incident lung and colorectal cancer in men and women: Results from the Henry Ford Exercise Testing (FIT) cohort

Cardiorespiratory fitness and incident lung and colorectal cancer in men and women: Results from the Henry Ford Exercise Testing (FIT) cohort

Impact on All-Cause and Cardiovascular Mortality Rates of Coronary Artery Calcifications Detected during Organized, Low-Dose, Computed-Tomography Screening for Lung Cancer: Systematic Literature Review and Meta-Analysis

Atherosclerotic diseases and lung cancer – a ten-year cross-sectional study in Cyprus

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