Lung cancer due to passive smoking - a review

Adlkofer, F.

doi:10.1007/s004200000221

Cited by 16 publications

(12 citation statements)

References 57 publications

(86 reference statements)

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“…In 1992, the United States Environmental Protection Agency (EPA) estimated that ETS is responsible for 3000 lung cancer deaths annually [2]. Since the US EPA report, three population-based studies [3][4][5][6] and several meta-analyses have provided further evidence for a direct association between ETS and lung cancer among never smokers [7][8][9][10][11]. However, evidence for a causal association between ETS and lung cancer has been inconsistently reported across studies [12,13].…”

Section: Introductionmentioning

confidence: 99%

Environmental tobacco smoke exposure in women with lung cancer

et al. 2004

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Section: Introductionmentioning

confidence: 99%

Environmental tobacco smoke exposure in women with lung cancer

et al. 2004

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“…ETS is qualitatively similar in composition to mainstream smoke and contains the same carcinogens, toxic compounds and oxidizers, albeit at lower concentrations than those inhaled by smokers [1]. Exposure to ETS has been causally linked to lung cancer [1, 3–6] and has some association with asthma in never-smoking adults [1, 5]. In children, ETS exposure has been linked to lower respiratory tract infections, asthma induction and exacerbation, and chronic respiratory symptoms such as wheezing and coughing [1, 5, 7, 8].…”

Section: Introductionmentioning

confidence: 99%

Environmental tobacco smoke effects on lung surfactant film organization

Stenger

Alonso

Zasadzinski

et al. 2009

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Adsorption of the clinical lung surfactants (LS) Curosurf or Survanta from aqueous suspension to the air-water interface progresses from multi-bilayer aggregates through multilayer films to a coexistence between multilayer and monolayer domains. Exposure to environmental tobacco smoke (ETS) alters this progression as shown by Langmuir isotherms, fluorescence microscopy and atomic force microscopy (AFM). After 12 hours of LS exposure to ETS, AFM images of Langmuir-Blodgett deposited films show that ETS reduces the amount of material near the interface and alters how surfactant is removed from the interface during compression. For Curosurf, ETS prevents refining of the film composition during cycling; this leads to higher minimum surface tensions. ETS also changes the morphology of the Curosurf film by reducing the size of condensed phase domains from 8–12 μm to ~ 2μm, suggesting a decrease in the line tension between the domains. The minimum surface tension and morphology of the Survanta film are less impacted by ETS exposure, although the amount of material associated with the film is reduced in a similar way to Curosurf. Fluorescence and mass spectra of Survanta dispersions containing native bovine SP-B treated with ETS indicate the oxidative degradation of protein aromatic amino acid residue side chains. Native bovine SP-C isolated from ETS exposed Survanta had changes in molecular mass consistent with deacylation of the lipoprotein. Fourier Transform Infrared Spectroscopy (FTIR) characterization of the hydrophobic proteins from ETS treated Survanta dispersions show significant changes in the conformation of SP-B and SP-C that correlate with the altered surface activity and morphology of the lipid-protein film.

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“…The question of secondary, second hand, or passive smoking will come out surely under these circumstances, and several sources have detailed the issue [18, 19]. In an obvious desperate attempt to control smoking in public environments, Albanian government passed an ad hoc bill, on November 2006, which forecasted severe fines applied to smokers; such fines in fact were never collected [20].…”

Section: Discussionmentioning

confidence: 99%

A Six-Month Study of Pulmonary Cancer in Albanian Women

Nikolla¹,

Nanushi

Vyshka

et al. 2013

ISRN Preventive Medicine

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Lung cancer is a potentially lethal disease, whose prevalence in Albania is constantly increasing, especially in women. Early diagnosis is extremely important with regard to life expectancy and quality. The authors conducted a survey on the behaviour in a sample group of Albanian women diagnosed with primary and secondary lung cancers. A discussion upon diagnostic methods, smoking habits, histological type, Karnofsky performance status (KPS), and treatment modalities is made. The data collected by the authors suggest that nonsmokers formed the main group of lung cancer female patients. The most frequent histological type was adenocarcinoma. Mesothelioma was the most frequent of the secondary pulmonary lung cancers, followed from metastasizing breast cancer. Despite a generally good performance of the cases, the diagnosis of pulmonary cancer is delayed. The data collected could not find a convincing etiological role of tobacco smoking, but caution is needed, regarding the short time length of the study and the sustained number of participants.

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Lung cancer due to passive smoking - a review

Cited by 16 publications

References 57 publications

Environmental tobacco smoke exposure in women with lung cancer

Environmental tobacco smoke exposure in women with lung cancer

Environmental tobacco smoke effects on lung surfactant film organization

A Six-Month Study of Pulmonary Cancer in Albanian Women

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