Lung Cancer Following Polonium-210 Inhalation in Rats

Yuile, Charles L.; Berke, H.L.; Hull, Thomas G.

doi:10.1097/00043764-196809000-00042

Cited by 3 publications

(4 citation statements)

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“…A strange result could be found in Figure (3) that the radioactivity of Catha edulis is greater than the radioactivity of tobacco; although the elemental analysis indicates that the radioactive elements in Tobacco much more than in Catha edulis, these reflect that we need more study of this complex subject. At the end, smoking of Tobacco and Catha edulis chewing simultaneously will double the effect of low radiation dose and create conditions that cause an oral and lung cancer in the long term [27], [28], [29], [30], [31].…”

Section: Resultsmentioning

confidence: 99%

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Al-Jalali¹

2014

International Journal of Physical Research

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The present work aims to shed light on the relationship between the cause of cancer and low radioactivity distribution of Catha edulis (Khat) and tobacco grown in Yemen, whereas they have a remarkable relationship with human health, due chewing of Catha edulis and smoking tobacco simultaneously. The complicated behavior of smoking tobacco and chewing Catha edulis at the same time could be responsible for different kinds of cancer diseases. Wavelength Dispersive X-ray Fluorescence (WDXRF) spectrometer was used to specify the chemical composition of Catha edulis and tobacco plants. In addition, radioactive detectors reveal the distribution of the radioactivity of Catha edulis and Tobacco plants is higher than the natural radioactivity distribution, because of the presence of the heavy minerals and different radioisotopes in Catha edulis and Tobacco plants.

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Section: Resultsmentioning

confidence: 99%

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Al-Jalali¹

2014

International Journal of Physical Research

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“…The 210 Po concentration in tobacco has a mean ± SD of 13 ± 2 Bq/kg (Persson and Holm 2011), and the estimated daily inhalation of 210 Po in smokers was between 13 and 590 mBq/day (Watson 1985). Zagà et al (2011) concluded that 210 Po is one of the most powerful carcinogens in tobacco smoke and, as previously noted, exposure of the lungs to 210 Po alone is capable of causing lung cancer in rats and hamsters (Little and O’Toole 1974; Yuile et al 1967). …”

Section: Tobacco Toxicology and 210pomentioning

confidence: 88%

“…Exposure of the lungs to 210 Po alone is capable of causing lung cancer in rats and hamsters (Little and O’Toole 1974; Yuile et al 1967). Injecting 210 Po into CF-1 female mice caused an increased incidence of lymphomas and soft-tissue and malignant-bone tumors (Finkel and Hirsch 1950).…”

Section: Toxicology Of 210pomentioning

confidence: 99%

Occurrence of ²¹⁰ Po and Biological Effects of Low-Level Exposure: The Need for Research

Seiler

2012

Environ Health Perspect

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Background: Polonium-210 (210Po) concentrations that exceed 1 Bq/L in drinking-water supplies have been reported from four widely separated U.S. states where exposure to it went unnoticed for decades. The radionuclide grandparents of 210Po are common in sediments, and segments of the public may be chronically exposed to low levels of 210Po in drinking water or in food products from animals raised in contaminated areas.Objectives: We summarized information on the environmental behavior, biokinetics, and toxicology of 210Po and identified the need for future research.Methods: Potential linkages between environmental exposure to 210Po and human health effects were identified in a literature review.Discussion: 210Po accumulates in the ovaries where it kills primary oocytes at low doses. Because of its radiosensitivity and tendency to concentrate 210Po, the ovary may be the critical organ in determining the lowest injurious dose for 210Po. 210Po also accumulates in the yolk sac of the embryo and in the fetal and placental tissues. Low-level exposure to 210Po may have subtle, long-term biological effects because of its tropism towards reproductive and embryonic and fetal tissues where exposure to a single alpha particle may kill or damage critical cells. 210Po is present in cigarettes and maternal smoking has several effects that appear consistent with the toxicology of 210Po.Conclusions: Much of the important biological and toxicological research on 210Po is more than four decades old. New research is needed to evaluate environmental exposure to 210Po and the biological effects of low-dose exposure to it so that public health officials can develop appropriate mitigation measures where necessary.

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“…Po on iron oxide particles indicates a seeming decrease in the tumor incidence as well as increased survival for the focal sources. Saunders, as a result of his studies with soluble 23 Pu derived from crushed microspheres arrives at a conclusion that spreading the dose more uniformly results in an increased cancer incidence due to the greater number of epithelial cells involved. This conclusion was based on the observation of "--a significant incidence of tumors in the lung and in other tissues at radiation doses that have not previously been shown to be carcinogenic in animals".…”

Section: Formentioning

confidence: 99%

Proposed interim standard for plutonium in soils

Healy¹

1974

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This report was prepared as an account of work sponsored by the United States Government. Neither the United States nor the United States Atomic Energy Commission, nor any of their employees, nor any of their contractors, subcontractors, or their employees, makes any warranty, express or implied, or assumes any lagal liability or responsibility for the accuracy, completeness or usefulness of any information, apparatus, product or process disclosed, or represents that its use would not infringe privately owned rights. In the interest of prompt distribution, this LAMS report was not edited by the Teehnteef Information staff.

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Lung Cancer Following Polonium-210 Inhalation in Rats

Cited by 3 publications

References 0 publications

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Occurrence of ²¹⁰ Po and Biological Effects of Low-Level Exposure: The Need for Research

Proposed interim standard for plutonium in soils

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Lung Cancer Following Polonium-210 Inhalation in Rats

Cited by 3 publications

References 0 publications

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Effects of low radioactivity of the Yemeni’s Catha edulis (Khat) and tobacco plants

Occurrence of 210 Po and Biological Effects of Low-Level Exposure: The Need for Research

Proposed interim standard for plutonium in soils

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Occurrence of ²¹⁰ Po and Biological Effects of Low-Level Exposure: The Need for Research