Lung cancer health disparities

Ryan, Bríd M.

doi:10.1093/carcin/bgy047

Cited by 83 publications

(85 citation statements)

References 188 publications

(222 reference statements)

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“…In TCGA-lung adenocarcinoma, AFR-derived tumours had higher detection rates of SBS4, attributed to tobacco exposure (LUAD: Δproportion = 0.39, 95%CI = 0.23-0.55, adjusted LNR p = 5.5x10 -3 ; Figure 2A, Supplementary Figure 2). Higher rates of SBS4 detection in AFR-derived lung adenocarcinoma despite reportedly comparable smoking rates between Black and White populations 52 may reflect differences in nicotine metabolism 53 , elevated use of mentholated cigarettes in Black populations 52,54 or simple selection bias in the cohort of lung adenocarcinomas studied in TCGA. In PCAWG-breast cancer, SBS3 occurred more frequently in AFR-derived samples (Breast-AdenoCA: Δproportion = 0.33, 95%CI = 0.13-0.54, adjusted LNR p = 0.097).…”

Section: Ancestry Associations In Mutational Signaturesmentioning

confidence: 99%

Ancestry Influences on the Molecular Presentation of Tumours

Haider

Boutros

2020

Preprint

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Epidemiological studies have identified innumerable ways in which cancer presentation and behaviour is associated with patient ancestry. The molecular bases for these relationships remain largely unknown. We analyzed ancestry associations in the somatic mutational landscape of 12,774 tumours across 33 tumour-types, including 2,562 with whole-genome sequencing. Ancestry influences both the number of mutations in a tumour and the evolutionary timing of when they occur. Specific mutational signatures are associated with ancestry, reflecting potential differences in exogenous and endogenous oncogenic processes. A subset of known cancer driver genes was mutated in ancestry-associated patterns, with transcriptomic consequences. Cancer genome sequencing data is not well-balanced in epidemiologic factors; these data suggest ancestry strongly shapes the somatic mutational landscape of cancer, with potential functional implications.

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Section: Ancestry Associations In Mutational Signaturesmentioning

confidence: 99%

Ancestry Influences on the Molecular Presentation of Tumours

Haider

Boutros

2020

Preprint

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“…On the other hand, the relevant literature showed that health disparities exist across a range of clinical settings [9,10]. Studies examining disparities of osteoporosis in the US multiethnic population are limited, and the distribution and trend of self-reported osteoporosis in the US population remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Trends and Disparities in Self-Reported and Measured Osteoporosis among US Adults, 2007–2014

Lin

2019

JCM

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(1) Background: Studies examining osteoporosis trends among US adults by different socioeconomic status (SES) are limited. The prevalence of self-reported osteoporosis in the US is rarely reported. (2) Methods: Data from the National Health and Nutritional Examination Survey (NHANES) between 2007–2008 and 2013–2014 cycles were analyzed. Age-adjusted prevalence of self-reported and that of measured osteoporosis were calculated overall and by sex, race/ethnicity, education attainment, and SES. (3) Results: The prevalence of self-reported osteoporosis was higher than that of measured osteoporosis in all three survey cycles for women, and in 2007–2008 and 2009–2010 for men. Participants with high school/GED or higher educational attainment had an increased prevalence of measured osteoporosis during the study period. Among all SES groups, participants with low family income (PIR < 1.3) had the highest prevalence of measured osteoporosis, and the prevalence increased from 49.3 per 1000 population to 71.8 per 1000 population during the study period. (4) Conclusions: The prevalence of self-reported osteoporosis was higher than that of measured osteoporosis in US adults between 2007 and 2014. The age-adjusted prevalence of measured osteoporosis increased in participants with the educational attainment of high school/GED or above, and individuals with low family income.

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“…Lung cancer-the second most common cancer in the United States and the leading cause of cancer-related death 5 -has persistent disparities in both incidence and mortality. AAs have the highest lung cancer incidence and mortality rates compared with other racial or ethnic groups 1,6 . These disparities persist even after considering tobacco smoking exposure-the strongest risk factor for lung cancer development 6 .…”

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confidence: 99%

“…AAs have the highest lung cancer incidence and mortality rates compared with other racial or ethnic groups 1,6 . These disparities persist even after considering tobacco smoking exposure-the strongest risk factor for lung cancer development 6 .…”

mentioning

confidence: 99%