Lung cancer in patients with and without rheumatoid arthritis: A propensity score‐matched survival analysis cohort study

Abstract

Background Connective tissue disease increases the risk of lung cancer, but whether rheumatoid arthritis (RA) has an effect on the overall survival (OS) rate in this population has not been well studied. Methods Patients diagnosed with lung cancer between January 2015 and December 2017 were enrolled in this retrospective analysis. Propensity score matching was performed to balance the baseline of the two groups, whereas the differences between patients with and without RA were compared using survival analysis. Further, the effects of interstitial lung disease (ILD) and qi deficiency on survival in cases of RA with lung cancer were examined. Cox regression analysis was applied to predict the factors that influenced the survival of lung cancer to one year. Results Overall, 154 lung cancer patients, including 136 (88.3%) without RA and 18 (11.7%) with RA, were included. Two comparison cohorts were matched by 1:2 propensity score matching, which yielded 18 lung cancer patients with RA and 36 lung cancer patients without RA. Ultimately, the survival prognosis of lung cancer and RA was worse than that without RA, that of patients with ILD with RA and lung cancer was worse than that among those without RA, and that of patients with qi deficiency with RA and lung cancer was worse than that among those without RA. Conclusions The survival prognosis of lung cancer patients with RA is worse than that of those without RA. ILD and qi deficiency promote reduced survival when found in conjunction with RA in patients with lung cancer.

Prognosis and prognostic factors of lung cancer complications in patients with rheumatoid arthritis

“…While direct comparisons cannot be made, these findings suggest the possibility that patients with RA may be experiencing earlier mortality due to complications associated with lung cancer. Zhang et al 12 . investigated the prognosis of lung cancer in a patient population in which more than 70% of patients had advanced stage III or higher lung cancer and showed that there was no significant difference in overall survival rate depending on the presence or absence of RA.…”

“…cancer. Zhang et al 12 investigated the prognosis of lung cancer in a patient population in which more than 70% of patients had advanced stage III or higher lung cancer and showed that there was no significant difference in overall survival rate depending on the presence or absence of RA. In our current study, although more than 60% of the patients had early-stage lung cancer, the overall survival rate of lung cancer did not differ between patients with and without RA.…”

Survival and prognostic factors of lung cancer patients with preexisting connective tissue disease: a retrospective cohort study

“…Several studies have addressed the prognosis of patients with LC and preexisting CTDs (Table S1). Most previous studies focused on comparing cancer survival rates between patients with and without CTDs (8,(25)(26)(27)(28)(29). In 2008, Adzić et al reported on the clinical features of 24 patients with LC and CTDs.…”

ALK-positive lung adenocarcinoma in a patient with rheumatoid arthritis with long-term treatment for organizing pneumonia: A case report

“…[ 3 ] Additionally, RA patients with lung cancer, particularly those with ILD, showed lower survival rates than patients with lung cancer without RA. [ 4 ]…”

“…[3] Additionally, RA Horie et al • Medicine (2022) Medicine patients with lung cancer, particularly those with ILD, showed lower survival rates than patients with lung cancer without RA. [4] Organizing pneumonia (OP) is a disease response from the pulmonary reaction to harmful factors, including infections and exposure to toxic substances, drugs, and radiotherapy. [5] Furthermore, OP can be observed in autoimmune disorders including RA.…”