Lung Cancer in Patients with HIV Infection and Review of the Literature

Abstract

LC occurs at a young age in HIV-infected smokers. LC is not associated with severe immunodeficiency. The prognosis is poor because of their initial extensive disease and a poor response to therapy. However, surgery appears to improve outcome in much the same way as in the general population.

Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity

“…In experimental animal models, COX-2 has been shown to be involved in tumor angiogenesis, suggesting that COX-2 is a potential target for cancer therapy. Several in vivo studies have already shown that COX-2-specific inhibitors (celecoxib and rofecoxib) have antitumor activity, and clinical trials using COX-2 inhibitors are currently ongoing in patients with lung caner (27,28).…”

Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum

“…Smoking is strongly associated with two of the primary causes of illness and death in HIV+ patients: community-acquired pneumonia (CAP) and Pneumocystis jiroveci pneumonia (formerly known as Pneumocystis ciroveci; Arcavi & Benowitz, 2004;Miguez-Burbano et al, 2005). HIV+ smokers are also at increased risk for oral lesions (Palacio et al, 1997) Beck & Slade, 1996), and AIDS-related spontaneous pneumothorax (Metersky et al, 1995).Young smokers infected with HIV may be particularly vulnerable to malignant tumors, such as lung cancer (Patel et al, 2006;Spano et al, 2004). Moreover, smoking by HIV+ patients may facilitate the progression to Acquired Immune Deficiency Syndrome (AIDS) (Neiman et al, 1993).…”

“…2004; Beck & Slade, 1996), and AIDS-related spontaneous pneumothorax (Metersky et al, 1995).Young smokers infected with HIV may be particularly vulnerable to malignant tumors, such as lung cancer (Patel et al, 2006;Spano et al, 2004). Moreover, smoking by HIV+ patients may facilitate the progression to Acquired Immune Deficiency Syndrome (AIDS) (Neiman et al, 1993).…”

Lung Cancer in HIV Infection

“…14,40,[54][55][56][57][58][59][60] With the exception of two retrospective studies, squamous cell cancer is the second commonest histological type (19-36%) in HIV-lung cancer patients, comparable to the 25% squamous cell cancer reported in HIV indeterminate individuals in the SEER data set. 49,53 The predominance of adenocarcinoma among HIVinfected individuals mirrors the changes in the distribution of the histological types of lung cancer seen in the general population.…”

“…40,[52][53][54][55][56][57][58][59][60][61][62] Yet, in a recent registry linkage study, the difference in the age at diagnosis of lung cancer was relatively modest between persons with AIDS and the general population (50 vs. 54 years) after adjusting for the underlying population structures. 31 In HIV-infected patients with lung cancer, men are significantly overrepresented compared to women, with a male-female sex ratio of 5-10:1.…”