Lung Cancer in Patients With Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis. A Descriptive Study in a Spanish Series

Portillo, Karina; Perez-Rodas, Nancy; García-Olivé, Ignasi; Guasch-Arriaga, Ignasi; Centeno, Carmen; Serra, Pere; Becker-Lejuez, Caroline; Sanz-Santos, José; Andreo, Felipe; Ruiz-Manzano, Juan

doi:10.1016/j.arbr.2017.04.006

Cited by 8 publications

(19 citation statements)

References 42 publications

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“…Lung cancer risk appears greater in CPFE (6.1-46.8 %) than in either IPF (4.4 -4.9%) or COPD alone. (4,7,26,28) LC was diagnosed in 11.6 % of our 230 CPFE cases while three prior studies reviewing smaller sample sizes found new cases occurring in 25% to 47% of their respective cohorts (4,12,13). Studies enrolling patients with diagnosed lung cancer as their primary study cohort also found significant incidence of associated CPFE, (12) including some demonstrating greater frequency of LC in CPFE than lone fibrosis (6,29).…”

Section: Discussionmentioning

confidence: 79%

“…A recent study evaluated LC risk in a series of 48 CPFE cases noting 12 (25%) going on to develop LC (4). A second study found 22 of 47 (46.8%) CPFE patients with incident LC (12), while a third and smaller study found 6 out of 29 (20.6%) developing subsequent LC (13). A recent metaanalysis describing LC in CPFE reported squamous cell carcinoma as the most common subtype (42.3%), followed by adenocarcinoma (34.4%) (5).…”

Section: Introductionmentioning

confidence: 99%

“…A recent metaanalysis describing LC in CPFE reported squamous cell carcinoma as the most common subtype (42.3%), followed by adenocarcinoma (34.4%) (5). LC in CPFE patients appeared to exhibit advanced pathological staging with relatively short survival [7,[9][10][11][12][13][14]. There is a single study to date reporting the location of presenting LC lesions in CPFE (6).…”

Section: Introductionmentioning

confidence: 99%

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Lung cancer in combined pulmonary fibrosis and emphysema: a large retrospective cohort analysis

Nasim

Moua

2020

ERJ Open Res

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BackgroundCombined pulmonary fibrosis and emphysema (CPFE) is characterised by upper lobe emphysema and lower lobe fibrosis. Our study aim was to determine the incident risk, presenting characteristics, and outcome of lung cancer (LC) diagnoses in a cohort of CPFE patients over time.Materials and MethodsWe conducted a retrospective cohort study assessing patients with radiologic CPFE followed over a median of 76 months (range 1–237). Interval development of LC and clinicopathologic characteristics of those with and without LC was compared and survival analysis performed.ResultsLC occurred in 26 of 230 (11.6%) CPFE patients dominated by non-small cell lung cancer (88%, N=23) with squamous cell carcinoma comprising the majority (N=13(57%)). There was a predominance of lower lobe (62%) and sub-pleural radiologic presentation (64%). Survival was reduced for the whole cohort by LC even after adjusting for a priori covariables of age, sex, smoking pack years, presenting forced vital capacity (FVC%), and radiologic honeycombing. Univariable predictors of increased mortality after LC diagnosis included honeycombing (HR 3.03 (1.16–7.91), p=0.02) and later stage presentation (HR 4.77 (1.8–14.94) p=0.001), with those able to undergo surgical resection having better survival (HR 0.29 (0.09–0.87) p=0.02).ConclusionLC occurred in 26 of 230 (11.6%) CPFE patients and was dominated by squamous cell carcinoma presenting in a lower lobe peripheral distribution. Surgical resection appeared to improve survival in selected patients with earlier stage disease. Further studies are needed to develop a relevant screening program for CPFE patients.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lung cancer in combined pulmonary fibrosis and emphysema: a large retrospective cohort analysis

Nasim

Moua

2020

ERJ Open Res

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“…The 13 studies contained a total of 1710 participants (603 in the CPFE group and 1107 in the IPF alone group) published between 2009 and 2017. Two of the trials were conducted in Europe, 18,20 two in North America, 8,11 and the remaining nine trials in east Asia. 9,10,12–17,19 The number of participants in each study ranged from 17 to 365 individuals.…”

Section: Resultsmentioning

confidence: 99%

Prognosis of combined pulmonary fibrosis and emphysema: comparison with idiopathic pulmonary fibrosis alone

Jiang

Zheng

2019

Ther Adv Respir Dis

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Background:Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome characterized by the coexistence of upper lobe emphysema and lower lobe fibrosis. However, whether CPFE has a higher or lower mortality than idiopathic pulmonary fibrosis (IPF) alone is still not clear. In this study we conducted a meta-analysis to assess the survival rate (SR) of CPFE versus IPF alone in clinical trials.Methods:We performed a systematic search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials for trials published prior to 31 March 2018. Extracts from the literature were analyzed with Review Manager version 5.3.Results:Thirteen eligible trials were included in this analysis (involving 1710 participants). Overall, the pooled results revealed that no statistically significant difference was detected in the 1-year [relative risk (RR) = 0.98, 95% confidence interval (CI): 0.94–1.03, p = 0.47], 3-year (RR = 0.83, 95% CI: 0.68–1.01, p = 0.06), and 5-year (RR = 0.80, 95% CI: 0.59–1.07, p = 0.14) SRs of CPFE versus IPF alone.Conclusions:CPFE exhibits a very poor prognosis, similar to IPF alone. Additional studies are needed to provide more convincing data to investigate the natural history and outcome of patients with CPFE in comparison to IPF. The reviews of this paper are available via the supplemental material section.

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“…Olgumuz kemik metastazından yapılan biyopsi ile ikinci sıklıkta görülen adenokanser tanısı kondu. Akciğer kanserine bağlı ortalama sağ kalım süresi KPFA grubunda, KPFA olmayan gruba göre daha düşüktür [5][6][7]14 . Erken evre KHDAK nedeniyle komplet rezeksiyon ve lenf nodu diseksiyonu yapılan olgularda bile KPFA sendromu varlığı sağkalımı düşüren önemli bir prognostik faktördür 5,7,[15][16][17]…”

Section: Discussionunclassified

Kombine pulmoner fibrozis ve amfizem sendromu: iki olgu sunumu

Bircan

Çelik

2019

Cukurova Medical Journal

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Lung Cancer in Patients With Combined Pulmonary Fibrosis and Emphysema and Idiopathic Pulmonary Fibrosis. A Descriptive Study in a Spanish Series

Cited by 8 publications

References 42 publications

Lung cancer in combined pulmonary fibrosis and emphysema: a large retrospective cohort analysis

Lung cancer in combined pulmonary fibrosis and emphysema: a large retrospective cohort analysis

Prognosis of combined pulmonary fibrosis and emphysema: comparison with idiopathic pulmonary fibrosis alone

Kombine pulmoner fibrozis ve amfizem sendromu: iki olgu sunumu

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