Lung Cancer in the Course of COPD-Emerging Problems Today

Uliński, Robert; Kwiecień, Iwona; Domagała‐Kulawik, Joanna

doi:10.3390/cancers14153819

Cited by 7 publications

(3 citation statements)

References 140 publications

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“…COPD is a significant risk factor for LC, regardless of smoking status. Lung inflammation and pulmonary matrix remodeling may serve as crucial precursors to the development of LC [ [170] , [171] , [172] ]. Details are shown in Fig.…”

Section: Association Between Chronic Obstructive Pulmonary Disease (C...mentioning

confidence: 99%

Glucocorticoids in lung cancer: Navigating the balance between immunosuppression and therapeutic efficacy

Xu,

Ye,

Cao

et al. 2024

Heliyon

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Section: Association Between Chronic Obstructive Pulmonary Disease (C...mentioning

confidence: 99%

Glucocorticoids in lung cancer: Navigating the balance between immunosuppression and therapeutic efficacy

Xu,

Ye,

Cao

et al. 2024

Heliyon

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“…Nicotine is linked to the development of several illnesses, including cancer [1]. Nicotine addiction is affected by genetics, social and environmental variables, and learned or conditioned behaviours [2].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Al-Tamemi,

Al-Okaily

2024

UPJOZ

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Background and Objective: Nicotine is linked to the development of several illnesses, including cancer The current study aimed to assess the ability of sodium thiosulfate (STS) to decrease the harmful effects of nicotine in lungs and gene expression of Bcl2 gene in rats and compare them with resveratrol (RES) supplement. Methods: Thirty-six male rats, Rattus norvegicus (weighing 190–220 g) were chosen randomly and separated into six equal groups. Animals in the control group were administered an intraperitoneal injection of normal saline, while those in group G1 were injected (I/P) with nicotine (1.5 mg/kg b.wt.). G2: were injected I/P with STS (450 mg/kg b.wt) and nicotine (1.5 mg/kg b.wt). G3: rats were gavaged with resveratrol supplement (87 mg/kg b.wt) and (I/P) injected with nicotine at the same dose. G4 group were (I/P) injected with STS (450 mg/kg b.wt) and administered (RES) (87 mg/kg b.wt) plus injected with nicotine (1.5 mg/kg b.wt). I/P injections of STS (450 mg/kg b.wt) and Resveratrol (87 mg/kg body weight) were given to group G5. All groups were administered for 28 days, after 24 hours after the last administration, all animals were sacrificed, and tissue specimens were collected from the lung for histopathological changes and for gene expression analysis of Bcl2. Results: The results of Lung sections for G1 showed severe peribronchiolar and perivascular lymphocytic cuffs, congestion, pulmonary emphysema, cuboidal metaplasia of the bronchiolar epithelium, granulomatous inflammation, thickening in the alveolar walls, and severe hemorrhage with hemosiderosis as compared with other experimental groups while group G2 showed that STS attenuating the effect of nicotine on lung tissue characterized by normal bronchioles which lined by normal columnar epithelium with scattered macrophages slight perivascular lymphocytic cuffs, a few desquamations of the bronchiolar epithelium, G3 group which administered RES showed that some alveoli had thickened walls; others showed slightly distended walls, few infiltrations of macrophages and lymphocytes, and desquamation of the bronchiolar epithelium. Moreover sections of lungs for G4 that administered both STS and RES with nicotine showed that most alveoli were normal, with slight thickening in their walls and slight blood vessel congestion. Furthermore, results represented a significant decrease in expression of the BCl2 gene for G1 compared with other groups. In contrast, a significant increase in the fold change of the BCL2 gene was observed in the G2, G3, G4, and G5 groups, indicating the protective effects of RES and STS on histopathological sections and fold change for the BCL2 gene against nicotine-stressed rats. Conclusion: Rats who received STS showed more effectiveness in modulating the bad effects of nicotine than those who received RES, which can give an idea that STS is more effective as an antioxidant than RES.

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“…This is a progressive respiratory disease manifesting by a largely irreversible airflow limitation due to airway obstruction, being the third leading cause of death (over 3 million) worldwide ( 8 ). In addition, both diseases are interconnected to some extent, and COPD has been identified as a risk factor for lung cancer development ( 9 , 10 ).…”

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confidence: 99%

Editorial: Comparison of lung cancer and chronic obstructive pulmonary disease in smokers and never-smokers

2023

Self Cite

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the Research Topic Comparison of lung cancer and chronic obstructive pulmonary disease in smokers and never-smokersTo the memory of Dr. Jerzy Szkudlarek, my best friend, who died of chronic obstructive pulmonary disease. Piotr Kus ́nierczyk Tobacco smoking was invented by Native Americans; archaeological evidence dates it to at least 2 300 years ago (1). However, smoking was not an everyday activity in these societies, as tobacco consumption, i.e. pipe smoking, was sacred, and smoking was limited to religious and social ceremonies (1). Many myths are associated with the origin of tobacco and smoking practices (1, 2). Unfortunately, at present, Native Americans are the population with the highest cigarette smoking rate among all ethnic groups in the United States of America, and the only one still growing, albeit slowly and nonsignificantly, in spite of efforts to promote smoking cessation (3).When America was "discovered" by Europeans, tobacco seeds and the custom of its smoking was imported to the Old Continent. Smoking lost its religious meaning and became an everyday custom leading to addiction, first mostly in men, but within the last 100 years increasingly so in women, particularly in less developed countries. In the years 1950-1952 it was noticed and described that lung cancer is associated with cigarette smoking (4-6). Since then, multiple publications confirming this observation and examining its different aspects have appeared: a PubMed search (Oct 14, 2022, "tobacco smoking and lung cancer") returns 1,096 results. As the numbers of never-smokers, as well as those having quit smoking increases, particularly in developed countries, the interest in the causes of lung cancer in never-smokers and former smokers is on the rise, and the number of publications on this topic is currently increasing (7), reaching 195 results in a PubMed search for "lung cancer never-smokers".

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Lung Cancer in the Course of COPD-Emerging Problems Today

Cited by 7 publications

References 140 publications

Glucocorticoids in lung cancer: Navigating the balance between immunosuppression and therapeutic efficacy

Glucocorticoids in lung cancer: Navigating the balance between immunosuppression and therapeutic efficacy

Effectiveness of Sodium Thiosulfate and Resveratrol in Remodeling Lung Injury and Expression of BCL2 in Nicotine-Stressed Rats

Editorial: Comparison of lung cancer and chronic obstructive pulmonary disease in smokers and never-smokers

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