Lung Cancer in the Young

Gálvez-Nino, Marco; Ruiz, Rossana; Pinto, Joseph A.; Roque, Katia; Mantilla, Raúl; Raez, Luis E.; López, Luis Alberto Moreno

doi:10.1007/s00408-019-00294-5

Cited by 37 publications

(32 citation statements)

References 35 publications

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“… 4 Our prospective cohort had a slightly higher percentage of patients with stage IV disease (79% versus 65%) and a similar percentage of EGFR mutations in all patients (28% versus 32%) but a higher percentage of ALK rearrangements (33% versus 19%). Compared with retrospective studies, our study reveals a similar percentage of never-smokers (73%; Table 2 ) 4 , 20 , 21 , 22 , 23 , 24 , 25 ; however, we saw greater percentages of EGFR and ALK alterations in nonsmokers.…”

Section: Discussionsupporting

confidence: 59%

“…One study had a subset of 81 patients who were younger than 40 years, with similar proportions of adenocarcinoma and female predominance. 4 Our prospective cohort had a slightly higher percentage of patients with stage IV disease (79% versus 65%) and a similar percentage of EGFR mutations in all patients (28% versus 32%) but a higher percentage of ALK Galvez-Nino et al 25 Chen et al 21 Liu et al 20 Pan et al 24 Tanaka et al 23 Sacher et al 4 Wang et al 22 Patient July 2021 GoYLC-Genomics of Young Lung Cancer rearrangements (33% versus 19%). Compared with retrospective studies, our study reveals a similar percentage of never-smokers (73%; Table 2) 4,[20][21][22][23][24][25] ; however, we saw greater percentages of EGFR and ALK alterations in nonsmokers.…”

Section: Discussionmentioning

confidence: 81%

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The Genomics of Young Lung Cancer: Comprehensive Tissue Genomic Analysis in Patients Under 40 With Lung Cancer

Gitlitz

Novello

Vavalà³

et al. 2021

JTO Clinical and Research Reports

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 81%

The Genomics of Young Lung Cancer: Comprehensive Tissue Genomic Analysis in Patients Under 40 With Lung Cancer

Gitlitz

Novello

Vavalà³

et al. 2021

JTO Clinical and Research Reports

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“…[59][60][61] Prevalence of RET alterations among young patients varies between 1.4% and 9.3%. 8,14,16,19,25,27,41 Four comparative studies have addressed alterations in RET. Three of them did not find significant differences between age groups.…”

Section: Genomic Profiling In Aya With Lung Cancermentioning

confidence: 99%

Genomic profiling in non-small-cell lung cancer in young patients. A systematic review

et al. 2021

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Lung cancer in young patients is an uncommon and understudied entity that harbors distinctive epidemiological, clinic-demographic, and genomic features. We carried out a systematic review of genomic profiling in young patients with lung cancer from 2010 to 2020 in the main electronic databases and selected 23 manuscripts. Lung cancer in young patients occurs more frequently in women with adenocarcinoma histology and at more advanced stages. Some studies report higher oncogenic genomic alteration in this population, with higher anaplastic lymphoma kinase rearrangements, a distinct profile of epidermal growth factor receptor mutations, and other novel genomic alterations. Although still uncommon, the implementation of next-generation sequencing (NGS) has shed some light on germline genomic alterations associated with lung cancer in young patients. Although outcomes when compared with the older population are conflicting, the overall prognosis is still poor in this subset of patients and efforts to find targetable genomic alterations should be made to improve survival.

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“…Lung cancer in patients younger than 40 years represents 4.3% of all cases as presented in a recent series. 10 Data from Metropolitan Lima Cancer Registry indicate as well that from 1968 to 2012, lung cancer incidence has decreased in men and increased in women (Fig. 2), 9 although the absolute number of cases is increasing because of population growth and aging.…”

Section: Epidemiologymentioning

confidence: 99%