Lung Cancer: Mechanisms of Carcinogenesis by Asbestos

Mossman, Brooke T.; Gualtieri, Alessandro F.

doi:10.1007/978-3-030-30766-0_12

Cited by 12 publications

(15 citation statements)

References 119 publications

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“…To calculate the FPTI of a mineral fiber, we used a model incorporating morphometric, chemical, biodurability related, and surface parameters of mineral fibers that affect their toxicity and pathogenicity upon inhalation (Gualtieri 2018;Mossman and Gualtieri 2020). Although a detailed description of the parameters is reported in Gualtieri (2018), a short summary is reported below.…”

Section: Determination Of the Fpti Of Yasniy Chrysotilementioning

confidence: 99%

“…To objectively and quantitatively compare the hazard represented by the different mineral fibers and especially chrysotile and amphibole asbestos, Gualtieri (2018) recently proposed a quantitative predictive model of toxicity/pathogenicity of minerals fibers based on the physical/chemical and morphological parameters that affect the biological activity. This model delivers an index (FPTI) aimed at ranking the toxicity and pathogenicity of mineral fibers (Gualtieri 2018;Mossman and Gualtieri 2020). To calculate FPTI, the model considers all the parameters that induce toxicity/pathogenicity, i.e., morphometric, chemical, biodurability related, and surface activity related parameters (Gualtieri 2018;Di Giuseppe et al 2019;Mossman and Gualtieri 2020).…”

Section: Introductionmentioning

confidence: 99%

“…This model delivers an index (FPTI) aimed at ranking the toxicity and pathogenicity of mineral fibers (Gualtieri 2018;Mossman and Gualtieri 2020). To calculate FPTI, the model considers all the parameters that induce toxicity/pathogenicity, i.e., morphometric, chemical, biodurability related, and surface activity related parameters (Gualtieri 2018;Di Giuseppe et al 2019;Mossman and Gualtieri 2020). In the work of Gualtieri (2018) a difference in the toxicity/pathogenicity potential of amphibole asbestos compared to chrysotile asbestos was highlighted based on their FPTI.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study a detailed characterization of Russian commercial chrysotile is presented and the FPTI model (Gualtieri 2018;Mossman and Gualtieri 2020) is applied with the aim of contributing to the global chrysotile issue. The calculated FPTI was compared to that of amphibole asbestos fibers and well-characterized chrysotiles: 1) Union for International Cancer Control (UICC) standard chrysotile asbestos "B" Canadian (NB #4173-111-1) from Quebec, Canada; 2) chrysotile asbestos from Balangero (Turin, Italy); and 3) chrysotile asbestos from Valmalenco (Sondrio, Italy).…”

Section: Introductionmentioning

confidence: 99%

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Characterization and assessment of the potential toxicity/pathogenicity of Russian commercial chrysotile

Giuseppe

Zoboli

Nodari

et al. 2021

American Mineralogist

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Today, cancer is one of the main health issues faced in the workplace, with asbestos an important carcinogen in the occupational environment. Among the asbestos minerals, chrysotile is the main species of socio-economic and industrial relevance. Although chrysotile asbestos is classified as a “carcinogenic substance” by the International Agency for Research on Cancer (IARC), this fiber is still mined and used in Russia. The effective health hazard posed by the Russian commercial chrysotile has not been quantitatively assessed to date. In this work, the potential toxicity/pathogenicity of Russian chrysotile was quantitatively determined using the fiber potential toxicity index (FPTI) model. This model was applied to a representative commercial chrysotile from the Orenburg region, Russia, whose morphometric, crystal-chemical, surface activity, and biodurability related parameters were determined. We have quantitatively assessed that the toxicity/pathogenicity potential of Russian chrysotile (FPTI = 2.4) is lower than that of amphibole asbestos species but higher than the threshold limit set for “safe” mineral fibers (FPTI = 2.0), although it does not contain impurities of amphibole asbestos. Differences with other chrysotile samples were discussed, and it was found that the investigated Russian commercial chrysotile shares several features with the Italian Balangero chrysotile, indicating that widespread concern on commercial Russian chrysotile is justified.

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Section: Determination Of the Fpti Of Yasniy Chrysotilementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization and assessment of the potential toxicity/pathogenicity of Russian commercial chrysotile

Giuseppe

Zoboli

Nodari

et al. 2021

American Mineralogist

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“…Foreign inhaled particles captured within the conducting zone take 15 min to 2 h to be cleared, with a speed of ~4–20 mm/min after inhalation [ 36 ]. Clearances of the deposited insoluble particles from the conducting zone also occur through phagocytosis by either alveolar macrophages moving up with the mucociliary escalator or macrophages entering the airways via bronchial and bronchiolar mucosa [ 37 ] and through epithelial endocytosis [ 38 ]. The majority of soluble particles from the conducting zone are cleared by an absorptive mechanism consisting of transepithelial permeation via intercellular pathways or by active and passive transcellular transport [ 39 ].…”

Section: Airways Systemmentioning

confidence: 99%

Dry Powder for Pulmonary Delivery: A Comprehensive Review

2020

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The pulmonary route has long been used for drug administration for both local and systemic treatment. It possesses several advantages, which can be categorized into physiological, i.e., large surface area, thin epithelial membrane, highly vascularized, limited enzymatic activity, and patient convenience, i.e., non-invasive, self-administration over oral and systemic routes of drug administration. However, the formulation of dry powder for pulmonary delivery is often challenging due to restrictions on aerodynamic size and the lung’s lower tolerance capacity in comparison with an oral route of drug administration. Various physicochemical properties of dry powder play a major role in the aerosolization, deposition, and clearance along the respiratory tract. To prepare suitable particles with optimal physicochemical properties for inhalation, various manufacturing methods have been established. The most frequently used industrial methods are milling and spray-drying, while several other alternative methods such as spray-freeze-drying, supercritical fluid, non-wetting templates, inkjet-printing, thin-film freezing, and hot-melt extrusion methods are also utilized. The aim of this review is to provide an overview of the respiratory tract structure, particle deposition patterns, and possible drug-clearance mechanisms from the lungs. This review also includes the physicochemical properties of dry powder, various techniques used for the preparation of dry powders, and factors affecting the clinical efficacy, as well as various challenges that need to be addressed in the future.

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Toxicology of Mineral Fibers and Implications for Risk Assessment

Mossman

2024

Health Risk Assessment for Asbestos and Other Fibrous Minerals

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Lung Cancer: Mechanisms of Carcinogenesis by Asbestos

Cited by 12 publications

References 119 publications

Characterization and assessment of the potential toxicity/pathogenicity of Russian commercial chrysotile

Characterization and assessment of the potential toxicity/pathogenicity of Russian commercial chrysotile

Dry Powder for Pulmonary Delivery: A Comprehensive Review

Toxicology of Mineral Fibers and Implications for Risk Assessment

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