Lung Cancer Mortality Trends in Spain Between 1980 and 2005

Cayuela, Aurelio; Rodríguez-Domínguez, Susana; Lόpez-Campos, José Luís; Vigil, Eduardo; Otero, Remedios

doi:10.1016/s1579-2129(08)60012-9

Cited by 15 publications

(13 citation statements)

References 30 publications

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“…The social gradients (positive for men and negative for women) were also observed by previous studies [26,27]. Taking into account that tobacco is responsible for 80% of cancers in this region, the patterns probably reflect the change in the consumption habits of the population, with higher prevalence in men from lower social classes and an increase from 1960 onwards in the number of women smokers from higher social classes [28][29][30]. The positive social gradient observed in men reflects the higher prevalence of smokers in areas of higher deprivation [31,32], in addition to a more substantial reduction in smoking in areas of lower deprivation [33].…”

Section: Lung Cancersupporting

confidence: 80%

Geographical variations in cancer mortality and social inequalities in southern Spain (Andalusia). 2002-2013

Santos-Sánchez

Córdoba-Doña

Viciana³

et al. 2020

PLoS ONE

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Introduction Geographical variations in cancer mortality can be explained, in part, by their association with social inequalities. The objective of our study was to analyse the spatial pattern of mortality in relation to the most common causes of cancer in the Spanish autonomous community of Andalusia and its possible association with social inequalities. Materials and methods A small area cross-sectional study in Andalusia, with census tracts as units of spatial analysis, for the period 2002-2013. Cases and person-years, sex and age group came from the Longitudinal Population Database of Andalusia. Standardized mortality rates and smoothed risk ratios were calculated using the Besag, York and Mollié model for lung, colorectal, breast, prostate, bladder and stomach cancer. In order to evaluate the association with social inequalities we included the deprivation index of the census tract as a covariate. Results The results show an East-West mortality pattern with higher risk in the west for lung and bladder cancer among men, and breast cancer among women. For all of Andalusia, the association between deprivation index of the census tract and mortality relative risks is positive and significant for lung, stomach and bladder cancers in men, while in women we observed a negative association for lung cancer and a positive for stomach cancer. Conclusions Knowledge regarding the spatial distribution of cancer mortality and the socioeconomic inequalities related should contribute to the design of specific health and social policies-PLOS ONE

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Section: Lung Cancersupporting

confidence: 80%

Geographical variations in cancer mortality and social inequalities in southern Spain (Andalusia). 2002-2013

Santos-Sánchez

Córdoba-Doña

Viciana³

et al. 2020

PLoS ONE

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“…With regard to lung cancer, the general tendency in European countries points towards a reduction among men (particularly young men) and an increase among women [ 51 ]. In Spain, the results are similar, rising among women and falling among men [ 32 ].…”

Section: Discussionmentioning

confidence: 98%

“…In recent decades, improvements in living conditions and the increasing inclusiveness of healthcare systems have reduced premature and, accordingly, avoidable mortality, both amenable and preventable. Several studies have analysed trends in mortality from avoidable causes over time in specific regions or groups [ 5 , 7 , 29 - 32 ] and found a decrease, although other studies described increases in avoidable mortality [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Trends in socioeconomic inequalities in preventable mortality in urban areas of 33 Spanish cities, 1996–2007 (MEDEA project)

Nolasco

Vasallo

Quesada

et al. 2015

Int J Equity Health

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BackgroundPreventable mortality is a good indicator of possible problems to be investigated in the primary prevention chain, making it also a useful tool with which to evaluate health policies particularly public health policies. This study describes inequalities in preventable avoidable mortality in relation to socioeconomic status in small urban areas of thirty three Spanish cities, and analyses their evolution over the course of the periods 1996–2001 and 2002–2007.MethodsWe analysed census tracts and all deaths occurring in the population residing in these cities from 1996 to 2007 were taken into account. The causes included in the study were lung cancer, cirrhosis, AIDS/HIV, motor vehicle traffic accidents injuries, suicide and homicide. The census tracts were classified into three groups, according their socioeconomic level. To analyse inequalities in mortality risks between the highest and lowest socioeconomic levels and over different periods, for each city and separating by sex, Poisson regression were used.ResultsPreventable avoidable mortality made a significant contribution to general mortality (around 7.5%, higher among men), having decreased over time in men (12.7 in 1996–2001 and 10.9 in 2002–2007), though not so clearly among women (3.3% in 1996–2001 and 2.9% in 2002–2007). It has been observed in men that the risks of death are higher in areas of greater deprivation, and that these excesses have not modified over time. The result in women is different and differences in mortality risks by socioeconomic level could not be established in many cities.ConclusionsPreventable mortality decreased between the 1996–2001 and 2002–2007 periods, more markedly in men than in women. There were socioeconomic inequalities in mortality in most cities analysed, associating a higher risk of death with higher levels of deprivation. Inequalities have remained over the two periods analysed. This study makes it possible to identify those areas where excess preventable mortality was associated with more deprived zones. It is in these deprived zones where actions to reduce and monitor health inequalities should be put into place. Primary healthcare may play an important role in this process.

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“…In 2005, 16647 men and 2471 women died from lung cancer, accounting for 27% and 7%, respectively, of all cancer deaths in Spain [3]. In Spain median survival rates of 40 weeks have been reported for patients with non-small cell lung cancer (NSCLC) [4] and 5-year survival is poor, estimated at only around 7% to 12% [2].…”

Section: Introductionmentioning

confidence: 99%

Cost-effectiveness analysis of pemetrexed versus docetaxel in the second-line treatment of non-small cell lung cancer in Spain: results for the non-squamous histology population

Asukai¹,

Valladares

Camps

et al. 2010

BMC Cancer

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BackgroundThe objective of this study was to conduct a cost-effectiveness evaluation of pemetrexed compared to docetaxel in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) for patients with predominantly non-squamous histology in the Spanish healthcare setting.MethodsA Markov model was designed consisting of stable, responsive, progressive disease and death states. Patients could also experience adverse events as long as they received chemotherapy. Clinical inputs were based on an analysis of a phase III clinical trial that identified a statistically significant improvement in overall survival for non-squamous patients treated with pemetrexed compared with docetaxel. Costs were collected from the Spanish healthcare perspective.ResultsOutcomes of the model included total costs, total quality-adjusted life years (QALYs), total life years gained (LYG) and total progression-free survival (PFS). Mean survival was 1.03 years for the pemetrexed arm and 0.89 years in the docetaxel arm; QALYs were 0.52 compared to 0.42. Per-patient lifetime costs were € 34677 and € 32343, respectively. Incremental cost-effectiveness ratios were € 23967 per QALY gained and € 17225 per LYG.ConclusionsPemetrexed as a second-line treatment option for patients with a predominantly non-squamous histology in NSCLC is a cost-effective alternative to docetaxel according to the € 30000/QALY threshold commonly accepted in Spain.

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Lung Cancer Mortality Trends in Spain Between 1980 and 2005

Cited by 15 publications

References 30 publications

Geographical variations in cancer mortality and social inequalities in southern Spain (Andalusia). 2002-2013

Geographical variations in cancer mortality and social inequalities in southern Spain (Andalusia). 2002-2013

Trends in socioeconomic inequalities in preventable mortality in urban areas of 33 Spanish cities, 1996–2007 (MEDEA project)

Cost-effectiveness analysis of pemetrexed versus docetaxel in the second-line treatment of non-small cell lung cancer in Spain: results for the non-squamous histology population

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