Lung Cancer Part I: Etiology, Pathology, Natural History, Manifestations, and Diagnostic Techniques

Filderman, Andrew E.; Shaw, Coralie; Matthay, Richard A.

doi:10.1097/00004424-198601000-00014

Cited by 43 publications

(9 citation statements)

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“…Also, small cell tumors were mostly centrally located, consistent with the literature. Adenocarcinoma is most commonly peripheral (55-60%) [15]. The rate of peripheral location of adenocarcinoma was close to the rate of central location in our study, which differs from the literature.…”

Section: Discussionsupporting

confidence: 66%

Lung Cancer Incidence in Erzurum City

Araz

Akgün

Görgüner

2010

EAJM

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Objective: Known as an uncommon disease at the beginning of the 20 th century, lung cancer has been the most frequent cause of cancer-related deaths in males since the 1950s and in females in the last two decades. The aim of this study was to determine the lung cancer incidence in Erzurum; its clinical properties, cancer subtypes, and application phases; the relationships of tumors with parameters of cigarette smoking and nutrition; radiological properties of the tumors; and the methods of diagnosis. Results: During the study period, 255 patients with a lung cancer diagnosis were accepted, 220 of whom were male (86.3%) and 35 were female (13.7%). The mean age of the patients was 63±1 years. The lung cancer incidence in Erzurum according to the data given by the hospitals that can diagnose lung cancer was determined to be 14.4/100.000. Lung cancer frequency increased with age, it was observed in males six times more frequently than females, and histopathologically non-small cell lung cancer and advanced phase lung cancer were more frequent. Materials and Methods Conclusion:The lung cancer incidence for Erzurum was not diff erent from that reported in other studies carried out both in the region and the whole country, and the lung cancer diagnosis was related to advanced age, male sexuality, active smoking and low socioeconomic state.Key Words: Erzurum, Incidence, Lung cancer Özet Amaç: Yirminci yüzyıl başlarında nadir bir hastalık olarak bilinen akciğer kanseri, 1950'li yılların başında erkeklerde, son 20 yılda da kadınlarda olmak üzere kansere bağlı ölümlerin en sık sebebi olmuştur. Bu çalışma ile bölgemizde akciğer kanser insidansı, klinik özellikleri, kanser alt tipleri, başvuru evreleri, tümörün içilen sigaranın cinsi ve beslenme ile ilişkisi, tümörün radyolojik özellikleri ve tanı konulma şekilleri gibi birtakım özellikler tespit edilmeye çalışıldı. idi. Hastaların yaş ortalaması 63±1 idi. Erzurum'da akciğer kanseri tanısı koyabilen hastanelerin verilerine göre Erzurum iline ait akciğer kanseri insidansı 14.4/100.000 olarak belirlendi. Kanser sıklığı yaş ilerledikçe arttığı, erkeklerde kadınlara göre yaklaşık 6 kat fazla görül-düğü, histopatolojik olarak küçük hücreli dışı akciğer kanseri ve ileri evre akciğer kanserinin fazla görüldüğü tespit edildi. Gereç veSonuç: Bu çalışmada bulunan Doğu Anadolu Bölgesi ve özellikle Erzurum için akciğer kanseri insidansının, geçmiş yıllarda hem böl-gemizde hem de ülke genelinde yapılan diğer çalışmalardan farklı olmadığı, ileri yaş, erkek cinsiyet, aktif sigara içimi düşük sosyoekonomik durum ile ilişki tespit edildi.

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Section: Discussionsupporting

confidence: 66%

Lung Cancer Incidence in Erzurum City

Araz

Akgün

Görgüner

2010

EAJM

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“…In previous reports based on mass screening by chest radiography, the VDT was apparently longer in adenocarcinoma than in squamous cell carcinoma (10,16,17). In chest radiograph screening, the mean VDT was approximately 110-220 days for adenocarcinoma and 90-130 days for squamous cell carcinoma (Table III) (10,16,17,21,22). In the present era of chest CT screening, this difference has become more evident.…”

Section: Discussionmentioning

confidence: 79%

“…adenocarcinoma but of unchanged VDT in squamous cell carcinoma even on the CT scan (2)(3)(4)10,17,21,22). Furthermore, bronchioloalveolar cell carcinoma, which has an extremely long VDT, has been detected only on chest CT scan screening (5-7).…”

Section: Discussionmentioning

confidence: 99%

Volume doubling time of lung cancers detected in a chest radiograph mass screening program: Comparison with CT screening

et al. 2012

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“…Data on tumour volume doubling time (Td) for human lung tumours are reported by Hasegawa et al (2000), Steel (1977), Usuda et al (1994), Fujimura et al (1979), Filderman et al (1986) and Geddes (1979). The data are summarised in Table 4.…”

Section: Repopulation and Tumour Doubling Timementioning

confidence: 99%

Accelerated regrowth of non-small-cell lung tumours after induction chemotherapy

2003

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Induction chemotherapy of non-small-cell lung cancer (NSCLC) stage III with gemcitabine and cisplatin for downstaging of the tumour with the aim for further treatment with ionising radiation is one of the treatments for lung cancer patients. The purpose of this study was to investigate the influence of the waiting time for radiotherapy, that is, the interval between induction chemotherapy and radiotherapy, on the rate of tumour growth for patients with NSCLC. Interval times between the end of induction chemotherapy and date of diagnostic CT, planning CT and first day of radiotherapy were determined for 23 patients with NSCLC. Increase in gross tumour volume was measured for 18 patients by measuring the dimensions of the primary tumour and lymph node metastases on the diagnostic CT after induction chemotherapy and on the CT used for radiotherapy planning. For each patient, the volume doubling time was calculated from the time interval between the two CTs and ratio of the gross volumes on planning CT and diagnostic CT. The mean time interval between end of chemotherapy and day of diagnostic CT was 16 days, and till first day of radiotherapy 80.3 (range 29 -141) days. In all, 41% of potentially curable patients became incurable in the waiting period. The ratio of gross tumour volumes of the two CTs ranged from 1.1 to 81.8 and the tumour doubling times ranged from 8.3 to 171 days, with a mean value of 46 days and median value of 29 days. This is far less than the mean doubling time of NSCLC in untreated patients found in the literature. This study shows that in the time interval between the end of induction chemotherapy and the start of radiotherapy rapid tumour progression occurs as a result of accelerated tumour cell proliferation: mean tumour doubling times are much shorter than those in not treated tumours. As a consequence, the gain obtained with induction chemotherapy with regard to volume reduction was lost in the waiting time for radiotherapy. We recommend diminishing the time interval between chemo-and radiotherapy to as short as possible.

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Lung Cancer Part I: Etiology, Pathology, Natural History, Manifestations, and Diagnostic Techniques

Cited by 43 publications

References 0 publications

Lung Cancer Incidence in Erzurum City

Lung Cancer Incidence in Erzurum City

Volume doubling time of lung cancers detected in a chest radiograph mass screening program: Comparison with CT screening

Accelerated regrowth of non-small-cell lung tumours after induction chemotherapy

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