Lung Cancer Recurrence: <sup>18</sup>F-FDG PET/CT in Clinical Practice

Kandathil, Asha; Sibley, Robert C.; Subramaniam, Rathan M.

doi:10.2214/ajr.19.21227

Cited by 23 publications

(24 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is the leading cause of death of all kinds of malignant tumors. [ 1 ] Many symptoms of LC are not specific until late stages. [ 2 ] The primary goal of systemic therapy in patients with advanced LC is to relieve symptoms and improve the quality of life and prolong the survival duration.…”

Section: Introductionmentioning

confidence: 99%

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Chen

Zhang

et al. 2021

Medicine

View full text Add to dashboard Cite

The main purpose of this study was to investigate current state of constipation for lung cancer (LC) patients receiving platinum-based chemotherapy. The relationships between social demography, clinical variables, psychological status, and constipation were analyzed. In addition, quality of life (QoL) in LC patients with constipation was also analyzed. One hundred LC patients participated in this cross-sectional study. Under the guidance of the researchers, Functional Living Index-Emesis, Piper Fatigue Scale, Patient Health Questionnaire, Generalized Anxiety Disorder-7, European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 (version 3.0), Pittsburgh Sleep Quality Index, General Well-being Scale, Social Support Rate Scale, General Self-Efficacy Scale, and other related questionnaires were completed. The result showed the symptom of constipation was observed in 41 (41%) LC patients. The occurrence and development of constipation were associated with gender, food intake, exercise, nausea, fatigue, anxiety, depression, sleep disorders, and happiness. The study also found patients with constipation had significant lower QoL scores, especially the score in the general state. Constipation was very common in LC patients undergoing platinum-based chemotherapy. Reduced food intake and fatigue were the independent factors. Constipation significantly affects the QoL of the patients. Therefore, more attention should be paid to the risk factors of constipation in LC patients undergoing platinum-based chemotherapy, the earlier intervention was done to these patients, the better to improve their QoL.

show abstract

Section: Introductionmentioning

confidence: 99%

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Chen

Zhang

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

“…PET can establish an initial staging of tumor lesions (2), enable treatment optimization, and evaluate treatment effectiveness or possible relapse (3)(4)(5)(6)(7)(8). It also provides prognostic parameters in certain types of cancer, in particular in onco-hematology, such as the Deauville score, which evaluates the therapeutic response and is used in clinical routine, or the total metabolic tumor volume (TMTV) (9).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of an Automatic Classification Algorithm Using Convolutional Neural Networks in Oncological Positron Emission Tomography

Pinochet¹,

Eude²,

Becker

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Introduction: Our aim was to evaluate the performance in clinical research and in clinical routine of a research prototype, called positron emission tomography (PET) Assisted Reporting System (PARS) (Siemens Healthineers) and based on a convolutional neural network (CNN), which is designed to detect suspected cancer sites in fluorine-18 fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT).Method: We retrospectively studied two cohorts of patients. The first cohort consisted of research-based patients who underwent PET scans as part of the initial workup for diffuse large B-cell lymphoma (DLBCL). The second cohort consisted of patients who underwent PET scans as part of the evaluation of miscellaneous cancers in clinical routine. In both cohorts, we assessed the correlation between manually and automatically segmented total metabolic tumor volumes (TMTVs), and the overlap between both segmentations (Dice score). For the research cohort, we also compared the prognostic value for progression-free survival (PFS) and overall survival (OS) of manually and automatically obtained TMTVs.Results: For the first cohort (research cohort), data from 119 patients were retrospectively analyzed. The median Dice score between automatic and manual segmentations was 0.65. The intraclass correlation coefficient between automatically and manually obtained TMTVs was 0.68. Both TMTV results were predictive of PFS (hazard ratio: 2.1 and 3.3 for automatically based and manually based TMTVs, respectively) and OS (hazard ratio: 2.4 and 3.1 for automatically based and manually based TMTVs, respectively). For the second cohort (routine cohort), data from 430 patients were retrospectively analyzed. The median Dice score between automatic and manual segmentations was 0.48. The intraclass correlation coefficient between automatically and manually obtained TMTVs was 0.61.Conclusion: The TMTVs determined for the research cohort remain predictive of total and PFS for DLBCL. However, the segmentations and TMTVs determined automatically by the algorithm need to be verified and, sometimes, corrected to be similar to the manual segmentation.

show abstract

“…9 [ 18 F]fluorodeoxyglucose ( 18 F-FDG) is the most commonly used molecular probe for PET, which is a glucose analogue that can indirectly reflect glucose metabolism and tumor cell proliferation. 10 In order to enable PET to more accurately evaluate tumors, the study of 18 F-FDG PET metabolism is particularly important.…”

Section: Introductionmentioning

confidence: 99%

Influencing Factors and Prognostic Value of 18F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer

Zhang¹,

Ren²,

Xu³

et al. 2021

IJGM

View full text Add to dashboard Cite

Objective: This study aims to explore factors influencing metabolic and volumetric parameters of [ 18 F]fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) imaging in non-small cell lung cancer (NSCLC) and the predictive value for prognosis of NSCLC. Methods: Retrospective analysis was performed on 133 NSCLC patients who received 18 F-FDG PET/CT imaging. After 18 F-FDG injection at 3.7 MBq/kg, 1 h early imaging and 2 h delayed imaging were performed. The metabolic and volumetric parameters such as SUVmax, SUVpeak, SULmax, SULpeak, MTV and TLG were measured. The tumor markers including CFYRA21-1, NSE, SCC-ag and the immunohistochemical biomarkers including Ki-67, P53 and CK-7 were examined. All patients were followed up for 24 months, and the 1-year and 2-year overall survival rate (OS) were recorded. Results: There were significant differences in metabolic and volumetric parameters (SUVmax, SUVpeak, SULmax, SULpeak and TLG) between adenocarcinoma and squamous cell carcinoma of NSCLC. SUVmax, SUVpeak, SULmax, SULpeak, MTV and TLG were correlated with tumor marker NSE and TNM stage. MTV and TLG were related to CYFRA21-1, and only MTV was associated with SCC-ag. SUVpeak and SULmax were related to P53. In addition, early SULpeak and delayed MTV were significant prognostic factors of 1-year OS, while early SUVpeak, delayed TLG and delayed MTV were predictive factors of 2-year OS in NSCLC. Conclusion:The metabolic and volumetric parameters of 18 F-FDG PET/CT were related to a variety of factors such as NSE, CFYRA21-1, SCC-ag, P53 and TNM stage, and have a predictive value in prognosis of NSCLC.

show abstract

Lung Cancer Recurrence: ¹⁸F-FDG PET/CT in Clinical Practice

Cited by 23 publications

References 54 publications

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Evaluation of an Automatic Classification Algorithm Using Convolutional Neural Networks in Oncological Positron Emission Tomography

Influencing Factors and Prognostic Value of 18F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer

Contact Info

Product

Resources

About

Lung Cancer Recurrence: 18F-FDG PET/CT in Clinical Practice

Cited by 23 publications

References 54 publications

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Associated factors with constipation and health-related quality of life in lung cancer patients with platinum-based chemotherapy

Evaluation of an Automatic Classification Algorithm Using Convolutional Neural Networks in Oncological Positron Emission Tomography

Influencing Factors and Prognostic Value of 18F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer

Contact Info

Product

Resources

About

Lung Cancer Recurrence: ¹⁸F-FDG PET/CT in Clinical Practice