“…In the past decades, the patterns of cancer epidemiology has changed dramatically caused by multiple factors, such as environmental pollution, and unhealthy lifestyles [ 14 ]. A number of clinical studies suggested a strong correlation between exposure to environmental pollution and the incidence and mortality rates of cancer [ [16] , [17] , [18] ], which was consistent with results in animal models [ 19 , 20 ]. In addition, a series of studies have revealed that the disruption of the endocrine system plays significant roles in the development of breast cancer [ 21 ], prostate cancer [ 22 ], thyroid cancer [ 23 ], and endometrial cancer [ 24 ].…”