Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

Boulanger, Mathilde; Tual, Séverine; Lemarchand, Clémentine; Guizard, Anne‐Valérie; Delafosse, Patricia; Marcotullio, Elisabeth; Pons, Romain; Piel, Clément; Pouchieu, Camille; Baldi, Isabelle; Clin, Bénédicte; Lebailly, Pierre

doi:10.1136/oemed-2017-104976

Cited by 35 publications

(20 citation statements)

References 34 publications

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“…The odds ratio in our study was slightly higher than in the Baser study but comparable with a cohort study by Alavanja et al [30]. Many other studies have proved that pesticides are associated with an increased risk of lung cancer in agriculture workers [30][31][32][33][34]. [3].…”

Section: Discussionsupporting

confidence: 86%

Excess Risk of Lung Cancer Among Agriculture and Construction Workers in Indonesia

Suraya¹,

Nowak

Sulistomo

et al. 2021

Annals of Global Health

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Section: Discussionsupporting

confidence: 86%

Excess Risk of Lung Cancer Among Agriculture and Construction Workers in Indonesia

Suraya¹,

Nowak

Sulistomo

et al. 2021

Annals of Global Health

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“…Similar results were replicated in later studies with the AHS cohort [ 10 ]. The AGRIculture and CANcer (AGRICAN) cohort study of French farmers also suggested associations between the risk of small-cell lung cancer and exposure to pesticides (HR, 2.38; 95% CI, 1.07 to 5.28) [ 11 ]. These significant trends in the risk of lung cancer were also observed in our adjusted results.…”

Section: Discussionmentioning

confidence: 99%

“…Increased lung cancer-related mortality among pesticide applicators has been reported [4][5][6][7][8], suggesting the possibility that exposure to pesticides may increase the risk of lung cancer among farmers [9]. In addition, previous cohort studies reported positive associations between exposure to pesticides and the occurrence of lung cancer [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Pesticides and Lung Cancer Risk: A Propensity Score Analyses

et al. 2022

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Occupational exposure to pesticides is thought to be associated with lung cancer, but studies have yielded conflicting results. We performed a propensity score (PS) based analyses to evaluate the relationship between occupational exposure to pesticides and lung cancer risk in the Korea National Cancer Center community-based cohort study (KNCCCS). Materials and MethodsDuring the follow-up period, 123 incidental lung cancer cases were identified, of the 7,471 subjects in the final statistical analysis. Information about occupational exposure to pesticides and other factors was collected at enrollment (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). Cox proportional hazards regression analyses were conducted. Four PS-based approaches (i.e., matching, stratification, inverse probability-of-treatment weighting, and the use of the PS as a covariate) were adopted, and the results were compared. PS was obtained from the logistic regression model. Absolute standardized differences according to occupational exposure to pesticides were provided to evaluate the balance in baseline characteristics. ResultsIn the Cox proportional hazards regression model, the hazard ratio (HR) for lung cancer according to occupational exposure to pesticides was 1.82 (95% confidence interval [CI], 1.11 to 2.98). With all the propensity score matching (PSM) methods, the HRs for lung cancer based on exposure to pesticides ranged from 1.65 (95% CI, 1.04 to 2.64) (continuous term with PSM) to 2.84 (95% CI, 1.81 to 4.46) (stratification by 5 strata of the PS). The results varied slightly based on the method used, but the direction and statistical significance remained the same. ConclusionOur results strengthen the evidence for an association between occupational exposure to pesticides and the risk of lung cancer.

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“…Europe, India, and Brazil are also major users of agricultural pesticides, which represent a potential problem for non-target organisms, including humans (Hossard et al 2017 ; Paumgartten 2020 ; Zheng et al 2020 ). In France, the AGRICAN (Agriculture and Cancer) cohort study, which began in 2005, has provided important insight into rare diseases due to the large number of participants—more than 181,000 individuals (Tual et al 2013 ; Lemarchand et al 2016 ; Piel et al 2017 , 2019 ; Boulanger et al 2018 ). One study in France showed that more than half (54.4%) of the 408 cases of occupational exposure to pesticides referred to a poison control center between 2012 and 2016 involved insecticides, while a third (33.3%) involved herbicides, and 12.2%, fungicides (Boucaud-Maitre et al 2019 ; Tual et al 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Cancer and occupational exposure to pesticides: a bibliometric study of the past 10 years

Pedroso

Benvindo‐Souza

Nascimento

et al. 2021

Environ Sci Pollut Res

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Graphical abstract Occupational exposure to pesticides has been identified as a major trigger of the development of cancer. Pesticides can cause intoxication in the individuals who manipulate them through either inhalation, ingestion, or dermal contact. Given this, we investigated the association between the incidence of cancer and occupational exposure to pesticides through a bibliometric analysis of the studies published between 2011 and 2020, based on 62 papers selected from the Scopus database. The results indicated an exponential increase in the number of studies published over the past decade, with most of the research being conducted in the USA, France, India, and Brazil, although a further 17 nations were also involved in the research on the association between cancer and pesticides. The principal classes of pesticides investigated in relation to their role in intoxication and cancer were insecticides, herbicides, and fungicides. The types of cancer reported most frequently were multiple myeloma, bladder cancer, non-Hodgkin’s lymphoma, prostate cancer, leukemia, and breast cancer. Despite the known association between pesticides and cancer, studies are still relatively scarce in comparison with the global scale of the use of these xenobiotic substances, which is related to the increasing demand for agricultural products throughout the world. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-021-17031-2.

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Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort

Abstract: Our results suggest associations between lung cancer and several crop-related tasks, even if we cannot rule out some chance findings due to multiple comparisons.

Cited by 35 publications

References 34 publications

Excess Risk of Lung Cancer Among Agriculture and Construction Workers in Indonesia

Excess Risk of Lung Cancer Among Agriculture and Construction Workers in Indonesia

Occupational Exposure to Pesticides and Lung Cancer Risk: A Propensity Score Analyses

Cancer and occupational exposure to pesticides: a bibliometric study of the past 10 years

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