Lung Cancer Susceptibility and hOGG1 Ser326Cys Polymorphism: A Meta-Analysis

Kiyohara, Chikako; Takayama, K.; Nakanishi, Yoichi

doi:10.3390/cancers2041813

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Distinct genes in the CHRNA5-CHRNA3-CHRNB4 region were associated with quantity smoked in people of European ancestry, Asians, and African-Americans (13). Other studies have investigated ethnic differences in polymorphisms in genes involved in carcinogen metabolism such as CYP1A1 (14), CYP1B1 (15), and GSTM1 (16), and in DNA repair (17) and DNA damage signaling (18), with respect to lung cancer incidence. Socioeconomic aspects of the observed ethnic differences have also been investigated (19-21).…”

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confidence: 99%

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

Park

Carmella

Ming

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Results of the Multiethnic Cohort study (MEC) demonstrated that, for the same quantity of cigarettes smoked, African Americans (AfrAm) and Native Hawaiians (NH) have a higher risk of lung cancer compared to Whites, whereas Latinos (LA) and Japanese Americans (JA) have a lower risk. We hypothesize that the uptake and/or metabolism of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) could explain the differences in lung cancer risk. Methods We measured urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides and their sum (total NNAL), biomarkers of NNK uptake, in 2,252 smokers from the MEC. Ethnic-specific geometric means were compared adjusting for age at urine collection, sex, creatinine and total nicotine equivalents, a marker of total nicotine uptake. Results AfrAm had the highest median total NNAL levels (1.80 pmol/ml urine) and JA the lowest (0.914 pmol/ml urine), with intermediate values in the other three groups. Geometric mean of total NNAL in AfrAm was also highest and in JA was lowest; JA geometric mean was statistically different from Whites (P=0.004). Conclusions AfrAm had higher levels of total NNAL per ml urine than Whites while JA had lower levels, consistent with lung cancer risk among smokers in these groups. However, our data were not consistent with the high and low lung cancer risks of NH and LA smokers, respectively. Impact The higher lung cancer susceptibility of AfrAm smokers and the lower susceptibility of JA smokers compared to Whites can be explained in part by exposure to the potent lung carcinogen NNK.

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Section: Introductionmentioning

confidence: 99%

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

Park

Carmella

Ming

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Association of vitamin D receptor FokI and ApaI polymorphisms with lung cancer risk in Tunisian population

Kaabachi

Rafrafi

et al. 2014

Mol Biol Rep

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Many studies reported that Vitamin D Receptor (VDR) gene polymorphisms might influence the cancer risk due to their antiproliferative, antiangiogenic, and apoptotic effects. The aim of this study was to explore the genetic association of VDR polymorphisms with lung cancer risk in Tunisian population. The genotype and haplotype frequencies of four VDR polymorphisms, FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were studied using polymerase chain reaction and restriction fragment length polymorphism analysis in 240 patients with lung cancer and 280 healthy controls. The distribution of genotype frequencies differed significantly between lung cancer subjects and controls (FokI P adj = 0.002; ApaI P adj = 0.013). Haplotype analyses revealed a significant association between G-A-C and A-C-T haplotypes and lung cancer risk (P corr = 0.0128, P corr = 0.008). When patients were stratified according to gender, age, and smoking, significant associations were detected with FokI and TaqI polymorphisms. We found a lack of association between BsmI, TaqI polymorphisms and lung cancer risk (P > 0.05). Only, the attributable proportion due to interaction and the synergic index for interaction between ApaI polymorphism and smoking were statistically significant (P adj = 0.74, 95 % CI = 0.38-1.20) and (P adj = 0.63, 95 % CI = 0.05-1.21), respectively. Both the additive interaction measures suggested the existence of a biological interaction between SNP ApaI, but not FokI, and smoking. The multiplicative interaction measure was not statistically significant (P > 0.05). This is the first study in Tunisia, which suggested that VDR FokI and ApaI polymorphisms might be risk factors for lung cancer development.

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Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort

et al. 2016

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Research from the Multiethnic Cohort (MEC) demonstrated that, for the same quantity of cigarette smoking, African Americans and Native Hawaiians have a higher lung cancer risk than Whites, while Latinos and Japanese Americans are less susceptible. We collected urine samples from 2,239 cigarette smokers from five different ethnic groups in the MEC and analyzed each sample for S-phenylmercapturic acid (SPMA), a specific biomarker of benzene uptake. African Americans had significantly higher (geometric mean [SE] 3.69 [0.2], p<0.005) SPMA/ml urine than Whites (2.67 [0.13]) while Japanese Americans had significantly lower levels than Whites (1.65 [0.07], p<0.005). SPMA levels in Native Hawaiians and Latinos were not significantly different from those of Whites. We also conducted a genome-wide association study in search of genetic risk factors related to benzene exposure. The glutathione S-transferase T1 (GSTT1) deletion explained between 14.2–31.6% (p = 5.4x10-157) and the GSTM1 deletion explained between 0.2%-2.4% of the variance (p = 1.1x10-9) of SPMA levels in these populations. Ethnic differences in levels of SPMA remained strong even after controlling for the effects of these two deletions. These results demonstrate the powerful effect of GSTT1 status on SPMA levels in urine and show that uptake of benzene in African American, White, and Japanese American cigarette smokers is consistent with their lung cancer risk in the MEC. While benzene is not generally considered a cause of lung cancer, its metabolite SPMA could be a biomarker for other volatile lung carcinogens in cigarette smoke.

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Lung Cancer Susceptibility and hOGG1 Ser326Cys Polymorphism: A Meta-Analysis

Cited by 3 publications

References 46 publications

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

Association of vitamin D receptor FokI and ApaI polymorphisms with lung cancer risk in Tunisian population

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort

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