Lung Cancer Trends in Southeastern Serbia

Kocić, Branislava; Petrović, Branislav; Rančić, Nataša; Ilić, Mirko

doi:10.21101/cejph.a3795

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…According to statistics, among the number of lung cancer cases in Serbia of southeastern Europe, the incidence rates in men were higher than those of women and the mortality rates of male patients were four times higher than those of female patients. This may be due to the smoking habit in males (2). According to the histological type of lung cancer, it can be divided into small cell lung cancer and non-small cell lung cancer (NSCLC).…”

Section: Introductionmentioning

confidence: 99%

High expression of miR-155 and miR-21 in the recurrence or metastasis of non-small cell lung cancer

Shi

2019

Oncol Lett

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High expression of miR-155 and miR-21 in the recurrence or metastasis of non-small cell lung cancer (NSCLC) was investigated. Retrospective analysis on the clinical information of 180 patients with NSCLC was carried out. The patients were admitted to Daqing Oil Field General Hospital from February 2012 to March 2015 and they were the research group. Moreover, the physical examination information of 88 normal medical examinees were selected at the same period of time as the control group. In the research group, 68 patients diagnosed with NSCLC were the newly diagnosed group and 112 cases of recurrence or metastasis of NSCLC were the recurrence group. The quantitative real-time polymerase chain reaction was used to detect the expression levels of serum miR-115 and miR-21. In addition, the expression levels between miR-155 and miR-21 and the relationship between the recurrence rate and metastasis of NSCLC were analyzed. The impact on the prognosis of patients were also analyzed. The expression levels of serum miR-155 and miR-21 were higher in the research group than those in the control group (P<0.05). The expression levels of serum miR-155 and miR-21 were higher in the recurrence group than those in the newly diagnosed group (P<0.05). We followed up the patients in the research group for 36 months, the median survival time and mortality rate in the recurrence group was higher than that of in the newly diagnosed group (χ 2 =9.705, P<0.01). In conclusion, miR-155 and miR-21 were highly expressed in the serum of patients, however, the recurrence and metastasis of NSCLC were even higher. The highly expressed levels of miR-155 and miR-21 were associated with the recurrence and metastasis in NSCLC patients, affecting the prognosis of patients.

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Section: Introductionmentioning

confidence: 99%

High expression of miR-155 and miR-21 in the recurrence or metastasis of non-small cell lung cancer

Shi

2019

Oncol Lett

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“…In our study, lung cancer incidence among men exceeds that in women with a male: female incidence gender ratio of 3.1:1, a result which had been reported in most nations. 19 In Serbia, the gender ratio (males to females) of lung cancer incidence was reported to be 4:1, 20 In Ardabil, Iran 21 4.6:1, Saudi Arabia 3.9:1, Kuwait 3.0:1, and the United Arab Emirate 2.8:1. 16 …”

Section: Discussionmentioning

confidence: 99%

“…Age as a risk factor for malignancies is well documented; it reflects intensity and long term exposure to risk factors such as lifestyle behaviors, particularly smoking. 20 Smoking is the leading cause of lung cancer and it was reported that 85-90% of lung cancer patients had a history of current or passive smoking. 36 …”

Section: Discussionmentioning

confidence: 99%

Lung cancer in Basrah, Iraq during 2005-2012

Habib

Al-Asadi

Hussein

2016

SMJ

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Objectives:To study the incidence rate of lung cancer and its time trend in Basrah during 2005-2012.Methods:This was a cancer registry-based retrospective study including all Basrah inhabitant patients diagnosed with primary lung cancer during the period from January 2005 to December 2012. The crude incidence rate was calculated in addition to the age standardized incidence rate (ASIR)/100,000 using the world standard population.Results:Out of 746 registered cases of lung cancer in Basrah, 75.9% were males and 24.1% were females with a male: female gender ratio of 3.1:1. The crude incidence rate was 3.93/100,000 (5.89/100,000 for males and 1.93/100,000 for females). The ASIR was 8.25/100,000 (13.30/100,000 for males and 4.08/100,000 for females). The time trend showed a decrease in incidence rate in the last 2 years (2011 and 2012) compared with the preceding years.Conclusion:The incidence rate of lung cancer in Basrah did not differ greatly from that reported for some Arab and neighboring countries. No definite time trend could be identified apart from a tendency for the incidence rate to decline in 2011 and 2012.

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“…Despite the immense efforts employed at the development of molecular targeted drugs, few efficient long-term therapeutic strategies for the advanced stages of LC exist due to fast-developing resistance 6. In Serbia, high unfavourable LC incidence and mortality trends showed a clear failure in primary and secondary prevention 7. Thus, earlier detection of LC would significantly improve outcomes and reduce the mortality burden.…”

Section: Introductionmentioning

confidence: 99%

TP53and DNA-repair gene polymorphisms genotyping as a low-cost lung adenocarcinoma screening tool

Čavić¹,

Spasić

Krivokuća

et al. 2018

J Clin Pathol

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AimTP53 and DNA repair polymorphisms have been proposed as cancer risk factors. This study evaluated the usability of TP53 Arg72Pro single-nucleotide polymorphism, XRCC1 Arg399Gln and RAD51 G135C as a low-cost lung adenocarcinoma screening tool.Patients and methodsThis case–control study included 78 atients with lung adenocarcinoma and 79 healthy matched controls. TP53, XRCC1 and RAD51 genotyping was done by PCR followed by restriction length polymorphism. Descriptive analyses included genotype and allelic frequencies and deviations of the frequencies from those expected under Hardy-Weinberg equilibrium were assessed using the χ2 test. The OR and 95% CIs were calculated as an estimate of relative risk, with significance set at p value <0.05.ResultsThe TP53 codon 72 Pro allele and the XRCC1 codon 399 Arg allele in a homozygous state were associated with lung adenocarcinoma (p=0.037; OR (95% CI) 2.42 (1.10 to 5.31)), that is, p=0.037; OR (95% CI) 2.16 (1.08 to 4.33), respectively. Also, carriers of the TP53 codon 72 Pro allele and the XRCC1 codon 399 ArgArg genotype older than 50 showed an even higher risk of developing lung adenocarcinoma (p=0.03 in both cases).ConclusionsThe TP53 codon 72 Arg allele and XRCC1 codon 399 Gln allele are likely to have a protective effect against lung adenocarcinoma, especially in individuals older than 50 years of age. XRCC1 and TP53 genotyping might be a useful low-cost tool for evaluating individual lung cancer risk, leading to earlier detection and management of this disease.

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Lung Cancer Trends in Southeastern Serbia

Cited by 3 publications

References 13 publications

High expression of miR-155 and miR-21 in the recurrence or metastasis of non-small cell lung cancer

High expression of miR-155 and miR-21 in the recurrence or metastasis of non-small cell lung cancer

Lung cancer in Basrah, Iraq during 2005-2012

TP53and DNA-repair gene polymorphisms genotyping as a low-cost lung adenocarcinoma screening tool

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