Lung Cancer Versus “Young Cancer”: Is Non-Small Cell Lung Cancer in Young Patients a Different Entity?

Bratová, Monika; Brat, Kristián; Hurdalkova, Karolina; Bařinová, Magda; Drösslerová, Marie; Kultan, Juraj; Wanke, Matyas; Koubková, Leona; Krejčí, Jana; Svatoň, Martin

doi:10.1089/jayao.2021.0069

Cited by 5 publications

(8 citation statements)

References 25 publications

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“…Although lung cancer is a rare disease in younger patients, it deserves major attention especially due to its poor prognosis 4,5,7,12 . More than 60% of young patients with NSCLC are diagnosed in an advanced clinical stage [3][4][5]12 . Some authors report that up to of 80% patients are diagnosed in clinical stage IV (ref.…”

Section: Discussionmentioning

confidence: 99%

“…There is conflicting data on survival outcomes of younger patients with lung cancer compared to older ones [3][4][5] as well as on the molecular genetic changes as drivers of carcinogenesis in this population [6][7][8][9][10][11] . The current investigation was on young patients with lung cancer whom we previously reported to have significantly worse survival than older age groups 12 .…”

Section: Introductionmentioning

confidence: 99%

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Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

Bratová¹,

Brat²,

Pavlovský³

et al. 2023

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

Bratová¹,

Brat²,

Pavlovský³

et al. 2023

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…This was also confirmed in a study by Mauri et al (14). However, Bratova et al (10) and Bryant et al (13) suggested that young NSCLC patients have worse survival rates than older NSCLC patients. Our study showed that the survival of stage IV NSCLC patients ≤45 years was superior to that of stage IV NSCLC patients >45 years.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Previous clinical series demonstrated that young NSCLC patients are more likely to be female, to be non-smokers, to have adenocarcinoma (ADC) subtypes, and to have advanced-stage diseases than older NSCLC patients (4,5,(9)(10)(11)(12)(13)(14)(15)(16). Furthermore, the survival rate of young patients is inferior to that of older patients (9)(10)(11)13). However, these studies focused on the entire entity of young NSCLC patients, and no literature is available about the clinicopathological features and prognosis of young stage IV NSCLC patients.…”

Section: Introductionmentioning

confidence: 99%

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Stage IV non-small cell lung cancer among young individuals: Incidence, presentations, and survival outcomes of conventional therapies

Cai

Qiu²,

Yang³

et al. 2022

Front. Oncol.

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BackgroundThere is a paucity of data published on the clinicopathological features and prognosis of stage IV non-small cell lung cancer (NSCLC) patients aged ≤45 years. Herein, we evaluated a large clinical series in an effort to provide a clearer picture of this population.MethodsThe least absolute shrinkage and selection operator (LASSO)-penalized Cox regression model was performed to identify prognostic factors for NSCLC among individuals aged ≤45 years. The Kaplan–Meier method with log-rank test was used to compare overall survival (OS) differences between groups. Competing risk analysis with the Fine–Gray test was used to analyze cancer-specific survival (CSS) differences. Propensity score matching (PSM) was used to minimize selection bias.ResultsIncidence-rate analyses, including 588,680 NSCLC cases (stage IV, 233,881; age ≤ 45 years stage IV, 5,483; and age > 45 years stage IV, 228,398) from 2004 to 2015, showed that the incidence of stage IV NSCLC among young individuals decreased over the years. In comparative analyses of clinical features and survival outcomes, a total of 48,607 eligible stage IV cases (age ≤ 45 years stage IV, 1,390; age > 45 years stage IV, 47,217) were included. The results showed that although patients in the young cohort were more likely to be diagnosed at advanced stages, they were also more likely to receive aggressive treatments. In addition, the survival rates of the young patients were superior to those of the older patients both before and after PSM.ConclusionsStage IV NSCLC patients aged ≤45 years comprise a relatively small but special NSCLC subgroup. Although this population had better survival outcomes than older patients, these patients deserve more attention due to their young age and the significant socioeconomic implications.

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Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients

Candal-Pedreira,

Ruano-Ravina,

Calvo de Juan

et al. 2024

Archivos de Bronconeumología

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Lung Cancer Versus “Young Cancer”: Is Non-Small Cell Lung Cancer in Young Patients a Different Entity?

Cited by 5 publications

References 25 publications

Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

Driver and actionable mutations in younger patients with lung cancer - are we searching properly?

Stage IV non-small cell lung cancer among young individuals: Incidence, presentations, and survival outcomes of conventional therapies

Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients

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