Lung cancer with dual<i>EGFR</i>and<i>ALK</i>driver alterations at baseline: a retrospective observational cohort study

Noronha, Vanita; Chougule, Anuradha; Chandrani, Pratik; Kaushal, Rajiv Kumar; Patil, Vijay; Menon, Nandini; Kapoor, Akhil; Chopade, Sunil; Singh, Ashish; Shetty, Omshree; Dutt, Amit; Banavali, Shripad; Prabhash, Kumar

doi:10.1080/0284186x.2022.2109426

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…All mechanisms are possible and may emerge in the same patient at different times over the course of the illness ( Lo Russo et al, 2017 ). Since the two alterations may coexist ab initio , the combination of EGFR -TKIs and ALK -TKIs may exert satisfactory efficacy, and further study is needed ( Noronha et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Case report: Concomitant EGFR mutation and ALK rearrangement in non-small cell lung cancer

Hu,

Tan,

Xie

et al. 2023

Front. Pharmacol.

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In non-small cell lung cancer (NSCLC), two key genetic alterations, epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements, are commonly believed to be mutually exclusive. Studies have reported that concurrent EGFR/ALK co-mutation in non-small cell lung cancer patients is rare, with a prevalence ranging from 0.1% to 1.6%. However, the clinical and pathological characteristics of these patients are not well-defined, and the optimal treatment approach for such cases remains controversial. In this report, we present a case of stage IV lung adenocarcinoma with both epidermal growth factor receptor and anaplastic lymphoma kinase mutations, along with high PD-L1 expression. The patient initially received treatment with epidermal growth factor receptor tyrosine kinase inhibitors (TKIs), but the disease progressed. However, following a switch to ALK-TKI therapy and local radiotherapy, the lesion showed regression. Our report also provides a comprehensive summary of the clinical and pathological features, as well as treatment strategies, for non-small cell lung cancer patients with concurrent epidermal growth factor receptor mutation and anaplastic lymphoma kinase rearrangement.

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Section: Discussionmentioning

confidence: 99%

Case report: Concomitant EGFR mutation and ALK rearrangement in non-small cell lung cancer

Hu,

Tan,

Xie

et al. 2023

Front. Pharmacol.

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Section: Social Media Marketing and Perceived Usefulnessmentioning

confidence: 99%

“…The social part can be depicted as a solitary's vocal or undeniable (nonverbal) tendency toward direct. It contains action and perceptible responses that are the consequence of a disposition object (Noronha et al, 2022). As demonstrated by Brady et al (2022), a comprehensive model of attitude and choice, such as the Psychological Affective Conative Model, is made by combining many surges of investigation on opinions, sentiments, and evaluative judgment on brand convictions(DEBA & SAKA, 2022).…”

Section: Perceived Usefulness Mediates the Relation Between Online Re...mentioning

confidence: 99%

Evaluating Impact of Social Media Marketing, Celebrity Endorsement and E-WOM on Online Repurchase Intention with the Mediating Role of Perceived Usefulness

Liaqat

2023

Pak. J. Humanit. Soc. Sci

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The purpose is to examine the impact of social media marketing, celebrity endorsement and e-wom on online repurchasing intentions with the mediating effect of perceived usefulness. In the continuous survey, assembles made from existing hypotheses, produce hypotheses, embrace frameworks for data arrangement and perform tests to exhibit the proposed hypothesis. The apparel industry is the main unit of analysis throughout the investigation of these variables. Our research is quantitative and also adopts a deductive approach. As a technique for advancing the large name stalwart's things and building up the relationship with the lovers, live trade gatherings (or live transmissions) between the genius force to be reckoned with and the allies can be set up on Instagram. These events could enable the Whiz amazing powerhouse and their allies to interface, which could augment thing bargains(Wahab et al., 2022). Speculatively, this study has shown that the development of disposition parts mental profound approach to acting may not commonly be dependable as a result of explicit factors. In this model, clients' viewpoints and objectives to buy things from enormous name stalwart brands are more grounded when they feel related to the celebrities' lives, triumphs, frustrations, wants, etc, as well as when they have solid areas for a bond with the celebrities, as affirmed by their super individual levels of celebrity love. Customers who show this commitment view themselves as the celebrity awe-inspiring phenomenon’s most noteworthy partners. When something enabling happens to them, they are especially excited about the notable awe-inspiring phenomenon. They could have a merry point of view toward a celebrity stalwart's achievement, for instance, when the celebrity force to be reckoned with gets or even think of them as their ideal accomplice. Along these lines, the buyers would wish to assist the hotshot with compelling to be dealt with's business attempts as undaunted disciples by buying things made by the large name. The survey's unessential revelations are more than likely achieved by the strong levels of respect and wonderment that a larger piece of the purchasers have for the celebrity forces to be reckoned with. This exploration is giving valuable data to the advertisers of Pakistan’s private sector universities in understanding consumers’ needs deeper in order to contribute to the growth of their business. The data is gathered through questionnaires. The data is aggregated through surveys. This specific framework and variables are only being used in Pakistan.

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Lung Cancer Detection using Transfer Learning and EfficientNet B2 Architecture

Bhola,

Kiran,

Ram

et al. 2023

2023 International Conference on Disruptive Technologies (ICDT)

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Lung cancer with dualEGFRandALKdriver alterations at baseline: a retrospective observational cohort study

Cited by 5 publications

References 24 publications

Case report: Concomitant EGFR mutation and ALK rearrangement in non-small cell lung cancer

Case report: Concomitant EGFR mutation and ALK rearrangement in non-small cell lung cancer

Evaluating Impact of Social Media Marketing, Celebrity Endorsement and E-WOM on Online Repurchase Intention with the Mediating Role of Perceived Usefulness

Lung Cancer Detection using Transfer Learning and EfficientNet B2 Architecture

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