Background: Lung cancer can be present with lung abscess in up to a third of lung abscess cases. However, lung cancer is often overlooked as an underlying condition while making a diagnosis of lung abscess. Case report: The authors present a case of a 69-year-old male that experienced a syncopal episode, accompanied by productive cough and shortness of breath. Lung abscess was diagnosed, and the patient was placed on antibiotics with no improvement in the cough after a week. Additional tests were performed, and latent squamous cell carcinoma was discovered. Conclusion: Since lung cancer can masquerade as lung abscess, physicians should have a high suspicion for lung cancer whenever there is a radiographic diagnosis of lung abscess, especially in patients with risk factors for lung cancer.