Lung carcinoma patients aged eighty years over and prognostic factors affecting survival

Kasapoğlu, Umut Sabri; Güngör, Sinem; Arınç, Sibel; Yalçınsoy, Murat; Misirlioglu, Aysun; Akbay, Özlem Makbule

doi:10.5578/tt.27881

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Approximately 50% of all cancers and 70% of cancer-related deaths occur in elderly persons aged ≥65 years. Hence, given the growing importance of cancer diagnosis, treatment, and follow-up in the elderly population, identifying effective biomarkers of prognosis and improved clinical outcomes is considered critical (3)(4)(5). Inflammation and tumor microenvironment are associated with cancer development and progression.…”

Section: Introductionmentioning

confidence: 99%

The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer

YILDIZ,

FINDIKÇIOĞLU,

KILIÇ

et al. 2023

Düzce Tıp Fakültesi Dergisi

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Aim: Today, there is an increase in cancer incidence and cancer-related deaths in the elderly population. This study aimed to evaluate the impact of neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) levels on the survival rate in elderly patients diagnosed with non-small cell lung cancer (NSCLC). Material and Methods: A total of 73 patients (aged ≥70 years) who operated for NSCLC between 2012 and 2018 were included in this study. Patient records were analyzed retrospectively. The NLR value was calculated with the blood neutrophil count/lymphocyte count formula. The cut-off value for NLR was considered as 2.5. The PNI value was calculated as 10 x serum albumin (g/dL) + 0.005 × total lymphocyte count (per millimeter). PNI values lower than 50 were considered as low. Results: The mean age of the patients was 74.15±3.23 years, 59 (80.8%) patients were male and 14 (19.2%) were female. No statistically significant relation of postoperative complication was noted with PNI (p=0.354) and NLR (p=0.483). Postoperative mortality was not significantly associated with PNI (p=0.188) and NLR (p=0.465). For patients with NLR <2.5, 1-, 3-, and 5-year survival rates were at 86.0%, 86.1%, and 78.3%, respectively, while these rates were at 76.9%, 65.2%, and 24.8%, respectively, for patients with NLR >2.5 (p=0.028). Conclusion: Results revealed a significant association of NLR with survival rates in elderly patients with NSCLC. NLR can be considered inexpensive, easily measurable, and reproducible marker that can be incorporated into routine clinical practice for guiding and optimizing treatment decisions in patients with NSCLC.

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Section: Introductionmentioning

confidence: 99%

The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer

YILDIZ,

FINDIKÇIOĞLU,

KILIÇ

et al. 2023

Düzce Tıp Fakültesi Dergisi

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“…Despite recent improvements in treatment, it continues to be the most vicious cancer type. In addition, while the incidence of this cancer type increases with age, its related mortality rate also increases, especially in the elderly population (1,2). Therefore, the diagnosis, treatment, and follow-up of cancer are essential in the elderly.…”

Section: Introductionmentioning

confidence: 99%

“…In geriatric age groups, especially in patients aged over 75 years, the lung cancer-related epidemiological data has been quite limited. Since the numbers of elderly patients participating in these studies were limited, the data remained insufficient, and this caused problems in the diagnosis and treatment approaches of elderly cancer patients (2).…”

Section: Introductionmentioning

confidence: 99%

Incidence of Primary Lung Cancers, Tumor Types, and Distribution of Demographic Characteri̇sti̇cs in Geriatric Patients: A 10-Year Retrospective Analysis of a Single Center

Çetin¹

2021

tjgeri

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Introduction:The incidence and mortality rates of lung cancer have increased throughout the 20th century, especially in the elderly population. This study aimed to determine the distribution of demographic characteristics of primary lung cancers in a geriatric age group in Aydin and its vicinity, and compare them with those reported in the literature.Materials and Methods: Overall, 1905 cases diagnosed within a 10-year period were included in the study. The cases were grouped based on their distributions of age, sex, anatomic localization, histological types, and year.Results: The mean age was 67.7 (SD 10.8) years; 1498 (78.6%) patients belonged to the geriatric group. The male and female sex ratios were higher in the geriatric and non-geriatric groups, respectively (p<0.001). In middle-aged and advanced-aged males, the decrease throughout the years, especially in the second half, was significant (p<0.001). The female diagnosis rate was higher during the second period (p<0.001). The resection rate was lower, whereas the biopsy rate was higher in the advanced age group (p<0.05). In all groups aged ≥65 years, the incidence of squamous cell carcinoma was higher and significantly increased with age (p<0.05). Conclusion:Our results emphasize the necessity of conducting detailed epidemiological studies involving hormonal, genetic, and regional factors such as indoor and outdoor air pollution, tobacco use. The insuffient treatment and toxicities experienced by elderly lung cancer patients with standard treatments are significant problems. Therefore, all elderly patients with lung cancer should be comprehensively evaluated for efficient, up-to-date treatments to reduce such problems.

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Tobacco and lung cancer in elderly patients located in southern marmara: epidemiological study

Akın¹

2022

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Objective: Lung cancer is the most common cancer type in men overall our country. It is fourth one in women after breast, thyroid and colorectal cancers. Enviromental factors have important role on the etiology such as tobacco is responsible from 80-90%. Namely as determined in epidemiological studies smokers has risk of lung cancer 20 times higher than non-smokers. Despite these knowledge near one million people worldwide are guessed to be tobacco smokers. Our aim in this study is to define distribution of lung cancer cases over 65 years and smoking ratios. Materials and Methods: 128 patients over 65 years involved the study from 351 lung cancer patients living in our region and referred to our clinic between 2015-2018. File records included clinical symptoms, histopathological data, clinical staging data, tobacco smoking habits, personal background, family history, applied treatment procedures and survival durations of the cases. Results: In our study 93.8 % (n=120) of the patients were men and 6.2% (n=8) were women. Mean age was 72.4±6.9 (65-87) years. Coughing (41,3%) was the mostly seen clinical symptom. Education data showed they were mostly (66,6%) graduated from primary school. 7,8% of them were non literated. We have seen carpenter, driver, miner and employee in our patients mainly (39,5%). Additionally 26,9% were farmer, 17,6% were tradespeople and 16% were whitecollar workers. Smoking ratio was 87,4% (n:97) in our lung cancer cases over 65 years. And 54,1% of these were smoking 2 packets/day, 19,8% were smoking 1 packet/day, 13,5% were smoking 3 packets/day. Duration of smoking was over 30 years in 72,1% of them. In lung cancer people over 65 years mostly seen histological subtype was squamosus cell cancer at 37,6% (n:46), adenocancer was at 30,1% (n:37), large cell cancer was at 14,6% (n:20), small cell cancer was at 16,3% (n:23) and mixed type was at 1,6% (n:2). Significant relation has found between smoking and histologycal type. Smokers had squamosus cell cancer (40,9%) whereas non-smokers had adenocancer (78,6%) mostly. 66,7% of the cases, most of them, were stage 4 at time of diagnose (n:84). 10,2% had performed surgery ,35,2% recieved chemoradiotherapy, 47,7% received chemotherapy and 12,5% had only received radiotherapy. In our clinic paclitaxel/carboplatin was used frequently 42,5% (n:37) as chemotherapy regimes in over 65 years. Overall survival were 339,440±424,494 days and progression free survival were 311,040±481,434 in our cases. Conclusion : Smoking rates are high in patients over 65 years with lung cancer living in our city. Stage of disease was mostly high at diagnose. Because of increasing treatment costs in addition to high mortality rates of lung cancer, we should support smoking cessation companies.

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Lung carcinoma patients aged eighty years over and prognostic factors affecting survival

Cited by 4 publications

References 15 publications

The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer

The Association between Inflammatory and Nutritional Markers and Survival in Elderly Patients Operated for Lung Cancer

Incidence of Primary Lung Cancers, Tumor Types, and Distribution of Demographic Characteri̇sti̇cs in Geriatric Patients: A 10-Year Retrospective Analysis of a Single Center

Tobacco and lung cancer in elderly patients located in southern marmara: epidemiological study

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